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Sub-Chronic Toxicity of Senilia senilis Hepatopancreas in Albino Wistar Mice


This study investigates the sub-chronic effects of shellfish possibly contaminated by algal toxins in albino Wistar mice. Following in-feed treatment with hepatopancreas, there were significant (p < 0.05) differences in packed cell volume, haemoglobin concentration, red blood cell count, lymphocyte count and alanine aminotransferase between the different treatment groups and control. Post mortem revealed inflammation and congestion in the gastrointestinal tract of the middle and highest dose groups. The stomach of the mice fed on the highest dose of the hepatopancreas showed severe ulcerations, leaving behind deep cavities and necrotic tissues on the glandular epithelium of the mucosal wall.

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The authors wish to thank Peter Okoye of the Histopathology Unit, University of Nigeria Teaching Hospital, Enugu; Austin Ngene, Medicine Laboratory, Department of Veterinary Medicine and Prof. J.A.O. Okoye, Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka for their technical assistance. We are grateful to Drs. John Burka and Collins Kamunde, Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Canada for their corrections of the manuscript. Funding was from the Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka and the Samuel N.C. Igboeli family. We are grateful to both sources of funds.

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Correspondence to Okechukwu O. Igboeli.

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Igboeli, O.O., Asuzu, I.U. Sub-Chronic Toxicity of Senilia senilis Hepatopancreas in Albino Wistar Mice. Bull Environ Contam Toxicol 84, 657–661 (2010).

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  • Shellfish toxins
  • Sub-chronic toxicity
  • Senilia senilis
  • Nigeria