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Dual Role of Vitamin C Utilization in NO2-Induced Oxidative Stress in Lung Tissues of Mice

Abstract

Earlier studies with in vitro models have revealed that application of vitamin C can act as a primary NO2 absorption substrate to contribute to NO2-induced cellular injury. In the present study, we showed that the pharmacological application of vitamin C had dual role in lungs of mice exposed to NO2, with an exacerbated oxidative stress occurring at low concentrations, as indicated by excessive reactive oxygen species production and lipid peroxidation. However, at high concentrations, vitamin C functioned as an antioxidant removing reactive oxygen species and maintaining a reducing status in cells, alleviating NO2-induced oxidative toxicity.

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Acknowledgments

We would like to thank Dr. Sheng T Hou (Institute for Biological Sciences, National Research Council of Canada) for comments on the manuscript. This research was partly supported by the National Natural Science Foundation of China (30570445) and Director Foundation of Experimental centre, Shenyang Normal University (SY200802).

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Correspondence to Lin Hao.

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Yingyi Zhang and Chunyan Ma contributed equally to this work.

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Zhang, Y., Ma, C., Xiao, Y. et al. Dual Role of Vitamin C Utilization in NO2-Induced Oxidative Stress in Lung Tissues of Mice. Bull Environ Contam Toxicol 84, 662–666 (2010). https://doi.org/10.1007/s00128-010-0021-1

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Keywords

  • Mice
  • Nitrogen dioxide
  • Vitamin C
  • Lipid peroxidation
  • Antioxidant defense