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Alterations in Differentially Expressed Genes in the Head of Oryzias latipes Following Benzo[a]pyrene Exposure


Differentially expressed genes (DEGs) in the head of medaka (Oryzias latipes) were investigated to assess the biological effects of benzo[a]pyrene (BaP) on genomic alterations. Eight and ten DEGs were identified in response to short (48 h) and long-term (15 days) exposure to BaP (25 μg/L), respectively, using annealing control primer-based polymerase chain reaction. Among the DEGs, matrilin 1 and prothrombin were commonly detected, suggesting that BaP exposure can alter the expression of genes associated with the formation of extracellular matrix and blood coagulation in the head of medaka.

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This study was funded by the National Fisheries Research and Development Institute, Pusan, Korea.

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Correspondence to Eun Sang Choe.

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Oh, J.H., Moon, HB. & Choe, E.S. Alterations in Differentially Expressed Genes in the Head of Oryzias latipes Following Benzo[a]pyrene Exposure. Bull Environ Contam Toxicol 84, 682–686 (2010).

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  • Polycyclic aromatic hydrocarbon
  • Environmental pollutant