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Determinations of MC-LR and [Dha7] MC-LR Concentrations and Physicochemical Properties by Liquid Chromatography-Tandem Mass Spectrometry

Abstract

A liquid chromatography electrospray mass spectrometry (LC/ESI/MS) method working in multiple reactions monitoring mode for the determination of trace amounts of microcystin variants (MC-LR and [Dha7] MC-LR) in waters was developed. The limit of quantification was 0.05 μg/L and the limit of detection was 0.015 μg/L for MC-LR and [Dha7] MC-LR, respectively. Recoveries for MCs were in the range of 68%–81%. MC-LR and [Dha7] MC-LR were chemically stable with similar physiochemical behavior.

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Acknowledgments

The authors acknowledge Dr. Jun Xu for his invaluable comments on our manuscript. This work was supported by a project from the Chinese Academy of Sciences (KZCX1-YW-14-6-1).

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Correspondence to Ping Xie.

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Yu, T., Xie, P., Dai, M. et al. Determinations of MC-LR and [Dha7] MC-LR Concentrations and Physicochemical Properties by Liquid Chromatography-Tandem Mass Spectrometry. Bull Environ Contam Toxicol 83, 757 (2009). https://doi.org/10.1007/s00128-009-9805-6

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Keywords

  • MC-LR
  • [Dha7] MC-LR
  • LC-MS
  • Physiochemistry