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Immunohistochemical and Histopathological Evaluation of 2,4-Dichlorophenoxyacetic Acid-Induced Changes in Rat Kidney Cortex


This study aims to investigate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on rat kidney cortex histology. Oral exposure of rats to 2,4-D for 28 days resulted in decreases in body weight gain and kidney weight. Histological examination showed degeneration in renal corpuscles and podocytes; vacuolization in the glomerulus with disintegration of the basal membrane; tissue edema; vacuolization, cystic dilation and invagination of the basal laminae in the tubular structures; dilation and congestion in renal corpuscular vessels and marked decrease in glomerular and stromal fibronectin reaction; suggesting that subacute 2,4-D administration induces dose-dependent histopathological degenerative effects in rat kidney cortex.

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This study has been presented in part at the VIII. National Histology and Embryology Congress, 27–30 June 2006, Malatya-Turkey. The authors would like to thank Mrs. Sevim Balkız, Belgin Kalmaz and Mr. İsmail Zonguldak for their technical help. This work was supported by The Research Fund of Ege University.

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Correspondence to Yiğit Uyanikgil.

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Uyanikgil, Y., Ateş, U., Baka, M. et al. Immunohistochemical and Histopathological Evaluation of 2,4-Dichlorophenoxyacetic Acid-Induced Changes in Rat Kidney Cortex. Bull Environ Contam Toxicol 82, 749–755 (2009).

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  • Herbicide
  • 2,4-D
  • Histopathology
  • Kidney
  • Rat