Abstract
The combined toxicity of lead (Pb) and nine phenols were measured. The result indicated that the combined toxicity is not only dependent on the Pb concentrations but also on the positions of substituted groups of phenols. Quantitative structure–activity relationship equations were built from the combined toxicity and physico-chemical descriptors of phenols in the different Pb concentrations. The combined toxicity was related to water solubility and the third order molecular connectivity index (3 X) in low Pb concentration, to solute excess molar refractivity (E) and ionization constant (pKa) in medium Pb concentration and to dipolarity/polarizability (S) in high Pb concentration.
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Abraham MH, Benjelloun-Dakhama N, Gola JMR, Acree WE, Cainc JWS, Cometto-Munizc JE (2000) Solvation descriptors for ferrocene, and the estimation of some physicochemical and biochemical properties. New J Chem 24:825–829. doi:10.1039/b004291i
Chen CY, Chen SL, Christensen ER (2005) Individual and combined toxicity of nitriles and aldehydes to Raphidocelis subcapitata. Environ Toxicol Chem 24(5):1067–1073. doi:10.1897/04-147R.1
Cronin MTD, Schultz TW (1996) Structure-toxicity relationships for phenols to Tetrahymena pyriformis. Chemosphere 32(8):1453–1468. doi:10.1016/0045-6535(96)00054-9
Grosell M, Gerdes RM, Brix KV (2006) Chronic toxicity of lead to three freshwater invertebrates-Brachionus calyciflorus, Chironomus tentans, and Lymnaea stagnalis. Environ Toxicol Chem 25(1):97–104. doi:10.1897/04-654R.1
Lu GH, Wang C, Tang ZY, Guo XL (2007) Quantitative structure–activity relationships for predicting the joint toxicity of substituted anilines and phenols to algae. Bull Environ Contam Toxicol 78:73–77. doi:10.1007/s00128-007-9005-1
Mochida K, Ito K, Harino H, Kakuno A, Fujii K (2006) Acute toxicity of pyrithione antifouling biocides and joint toxicity with copper to red sea bream (Pagrus major) and toy shrimp (Heptacarpus futilirostris). Environ Toxicol Chem 25(11):3058–3064. doi:10.1897/05-688R.1
Nirmalakhandan N, Xu S, Trevizo C (1997) Additivity in microbial toxicity of nonuniform mixtures of organic chemicals. Ecotoxicol Environ Saf 37:97–102. doi:10.1006/eesa.1997.1530
Otitoloju AA (2002) Evaluation of the joint-action toxicity of binary mixtures of heavy metals against the mangrove periwinkle Tympanotonus fuscatus var radula (L.). Ecotoxicol Envrion Saf 53:404–415. doi:10.1016/S0147-6513(02)00032-5
Schultz TW (1987) The use of the ionization constant (pKa) in selection models of toxicity in phenols. Ecotoxicol Environ Saf 14:178–183. doi:10.1016/0147-6513(87)90060-1
Shaw JR, Dempsey TD, Chen CY, Hamilton JW, Folt CL (2006) Comparative toxicity of cadmium, zinc, and mixtures of cadmium and zinc to daphnids. Environ Toxicol Chem 25(1):182–189. doi:10.1897/05-243R.1
Thomulka KW, Abbas CG, Young DA, Lange JH (1996) Evaluating median effective concentrations of chemicals with bioluminescent bacteria. Bull Environ Contam Toxicol 56:446–452. doi:10.1007/s001289900064
Xu S, Nirmalakhandan N (1998) Use of QSAR models in predicting joint effects in multi-component mixtures of organic chemicals. Water Res 32:2391–2399. doi:10.1016/S0043-1354(98)00006-2
Yangjeh AH, Jenagharad MD, Nooshyar M (2006) Application of artificial neural networks for predicting the aqueous acidity of various phenols using QSAR. J Mol Model 12:338–347. doi:10.1007/s00894-005-0050-6
Yuan X, Lu GH, Su LM (2005) Correlation study of toxicity of substituted phenols to river bacteria and their biodegradability in river water. Biomed Environ Sci 18:281–285
Zissimos AM, Abraham MH, Barker MC, Boxb KJ, Tam KY (2002) Calculation of Abraham descriptors from solvent–water partition coefficients in four different systems; evaluation of different methods of calculation. J Chem Soc Perkin Trans 2:470–477. doi:10.1039/b110143a
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This research was financed by the National Nature Science Foundation of China (40673059) and Science Foundation for Young Teachers of Northeast Normal University (20080501).
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Su, L.M., Zhao, Y.H., Yuan, X. et al. Evaluation of Combined Toxicity of Phenols and Lead to Photobacterium phosphoreum and Quantitative Structure–Activity Relationships. Bull Environ Contam Toxicol 84, 311–314 (2010). https://doi.org/10.1007/s00128-009-9665-0
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DOI: https://doi.org/10.1007/s00128-009-9665-0