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Hydrogen Peroxide Reduces Lead-Induced Oxidative Stress to Mouse Brain and Liver

Abstract

Lead (Pb) intoxication may initiate many disorders in human and animals. This study investigates the role of exogenous hydrogen peroxide (H2O2) in inducing mouse tolerance to Pb exposure. Results showed that the simultaneous application of 1.2 μg H2O2 per kg body weight efficiently protected mice against the Pb-caused injury, as revealed by decreased growth suppression caused by the Pb stress, increased antioxidative enzyme activity, reduced lipid peroxidation, and the protective effect on the nuclear DNA integrity. To our knowledge, this is the first finding of this sort.

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Acknowledgments

We thank Dr Sheng T Hou (Institute for Biological Sciences, National Research Council of Canada) for comments on the manuscript. This research was supported partly by the National Natural Science Foundation of China (30570445), Natural Science Foundation of Liaoning Province (No. 20021022), Tackle Key Problem of Science and Technology, Education Department of Liaoning Province (2004D005) and Director Foundation of Experimental Centre, Shenyang Normal University (SY200802).

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Correspondence to L. Hao.

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R. G. Li and T. T. Li contributed equally to this work.

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Li, R.G., Li, T.T., Hao, L. et al. Hydrogen Peroxide Reduces Lead-Induced Oxidative Stress to Mouse Brain and Liver. Bull Environ Contam Toxicol 82, 419 (2009). https://doi.org/10.1007/s00128-008-9599-y

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Keywords

  • Mice
  • Lead
  • Hydrogen peroxide
  • Oxidative stress