Skip to main content

Facile and Rapid Determination of Contamination in Sulphur Pesticide Formulations by Liquid Chromatography–Tandem Mass Spectrometry


Up to 7% of pesticide products in the European market are illegal, counterfeit or of poor quality. As a result, regulatory authorities are required to determine a wide variety of impurities in many different pesticide formulations. A simple, rapid and exceptionally reliable LC-MS-MS method for the determination of carbendazim residual quantities in sulphur formulations, used in organic agriculture, has been developed and validated. Linearity of response was established (R 2 = 0.9997) over a wide range of concentrations (0.01–2 μg/mL). Recovery ranged from 94% to 101%. LOD and LOQ were 0.003 μg/mL and 0.005 μg/mL, respectively, and lack of interference was confirmed.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3


  1. Brito NM, Navickiene S, Polese L, Jardim EFG, Abakerli RB, Ribeiro ML (2002) Determination of pesticide residues in coconut water by liquid–liquid extraction and gas chromatography with electron-capture plus thermionic specific detection and solid-phase extraction and high performance liquid chromatography with ultraviolet detection. J Chromatogr A 957:201–209. doi:10.1016/S0021-9673(02)00351-5

    Article  CAS  Google Scholar 

  2. CIPAC (1998) Handbook Vol. H analysis of technical and formulated pesticides. In: Dobrat W, Martijn A (eds) Black Bear Press Ltd, King’s Hedges Road, Cambridge, UK

  3. ECPA (2006) news release, 26 April 2006, reached on 30th January 2008

  4. ECPA (2006) news release, 17 October 2006,

  5. ECPA (2007) news release, 29 March 2007,, reached on 30th January 2008

  6. EPA (1996) Pesticide registration-PR-notice 96-8/31.10.1996

  7. Michel M, Buszewski B (2004) Optimization of a matrix solid-phase dispersion method for the determination analysis of carbendazim residue in plant material. J Chromatogr B 800:309–314

    Article  CAS  Google Scholar 

  8. Naftemporiki (2007) Issue of 27-9-2007 p 10

  9. Pizzutti IR, de Kok A, Zanella R, Adaimea MB, Hiemstra M, Wickert C, Prestes OD (2007) Method validation for the analysis of 169 pesticides in soya grain, without clean up, by liquid chromatography–tandem mass spectrometry using positive and negative electrospray ionization. J Chromatogr A 1142(2):123–136

    Article  CAS  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to George Panos Balayiannis.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Balayiannis, G.P., Anagnostopoulos, H. & Kellidou, I. Facile and Rapid Determination of Contamination in Sulphur Pesticide Formulations by Liquid Chromatography–Tandem Mass Spectrometry. Bull Environ Contam Toxicol 82, 133–136 (2009).

Download citation


  • Pesticides
  • Impurities
  • Organic agriculture
  • LC-MS-MS