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Atrazine Exposure Decreases Cell Proliferation in Chinese Hamster Ovary (CHO-K1) Cell Line

Abstract

The aim of this study was to determine the toxic effect of atrazine at the ovarian cellular level. Chinese Hamster Ovary (CHO-K1) cell line was used to evaluate the degree of in vitro atrazine cytotoxicity and the morphological changes were followed during the cell death. Application of four bioassays confirmed that atrazine decreases ovarian cell proliferation and IC50 were determined with each assay after 72 h of exposure. The level of apoptosis in atrazine treated cells was low.

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Acknowledgments

This study was supported by Ministry of Science, Education and Sports of the Republic of Croatia, grants no. 0582184-2232 and no. 0582184-2414.

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Correspondence to J. Kniewald.

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Kmetič, I., Gaurina Srček, V., Slivac, I. et al. Atrazine Exposure Decreases Cell Proliferation in Chinese Hamster Ovary (CHO-K1) Cell Line. Bull Environ Contam Toxicol 81, 205–209 (2008). https://doi.org/10.1007/s00128-008-9425-6

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Keywords

  • Atrazine
  • CHO-K1 cells
  • IC50 values
  • Apoptosis