Determination of Iodine in Low Mass Human Hair Samples by Inductively Coupled Plasma Mass Spectrometry
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As an essential trace element, iodine plays a crucial role in human metabolic processes. It is a major component of the thyroid hormones thyroxin (T4) and iodothyronine (T3), which are necessary for proper brain development and function (Hollowell et al. 1998). When dietary requirements for iodine are not met thyroid hormone synthesis is impaired, resulting in a series of developmental and functional problems referred to collectively as IDD, or iodine deficiency disorders (WHO 2004). Although iodine deficiency can adversely impact human health at all stages of life, it can be especially devastating to a developing fetus or newborn, causing brain damage, irreversible mental retardation, and other growth defects (Utiger 1999, 2006).
People living in areas with low environmental levels of iodine are more likely to develop IDD. Approximately one-third of the global population lives in such areas, including some of the large, industrialized countries of Europe (Dunn 1998; Jahreis et al. 2001...
KeywordsIodine Hair Sample Iodine Deficiency Iodine Concentration Urinary Iodine Concentration
The authors thank Professor James B. Adams (Arizona State University) for providing the study samples. This analytical work was funded in whole by the National Institute of Environmental Health Sciences, National Institute of Health, Contract Numbers: N01-ES-05455 and N01-ES-65554.
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