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Effect of Selenium Pretreatment in Chronic Mercury Intoxication in Rats


Effect of selenium pretreatment (0.2 mg/kg/day, as sodium selenite), 4 h prior to mercury treatment (0.4 mg/kg/day, as mercuric chloride), administered intraperitoneally, was examined after daily exposure for 20 days’ in rats. Liver, kidney and brain tissues were assayed for malondialdehyde (MDA) level, glutathione (GSH) content and mercury concentration. Mercury induced MDA levels, which was also observed in selenium pretreated animals. Significant reduction in GSH levels was observed in mercury alone and selenium pretreated animals. Mercury accumulation was in the order of kidney, liver and brain. Selenium pretreatment resulted in further enhancement in mercury accumulation in liver and kidney.

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Thanks are due to Director, ITRC for his encouragement in the work. Technical assistance rendered by Mr. Ramesh Candra, TO and the overall help by Mr. Ram Chandra in the work is duly acknowledged. Rakhi Agarwal is grateful to UGC, India for the award of Junior Research Fellowship (JRF).

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Correspondence to J. R. Behari.

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Agarwal, R., Behari, J.R. Effect of Selenium Pretreatment in Chronic Mercury Intoxication in Rats. Bull Environ Contam Toxicol 79, 306–310 (2007).

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  • Mercury toxicity
  • Selenium pretreatment
  • Chronic exposure
  • Rats