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Quality of life outcome in a randomized controlled trial of case management

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Background: This paper presents the quality of life (QOL) outcome results from the UK700 randomised controlled trial of case management. Method: A total of 708 patients with severe mental illness were randomly assigned to intensive and standard forms of case management in four sites in the UK. QOL was assessed using the Lancashire Quality of Life Profile, which provides a self-reported objective and subjective appraisal of eight life domains (finances, work, leisure, family, social relations, living situation, safety and health). The outcome after 2 years was examined using univariate and multivariate analyses. Results: Significant improvements in QOL over the 2 years were observed. The QOL outcome did not differ significantly by case management treatment conditions or by diagnosis. A better outcome was associated with improvements in depression and with the location (site) of treatment. In one site there were significant improvements in all eight domains and overall QOL, with moderate or better effect sizes (> 0.4) in three domains and overall QOL. Conclusions: Depression should be assessed when subjective QOL measures are used. Better means for describing service organisations and the context/place in which they operate should be developed in order to explain more of the variance in QOL outcomes.

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Accepted: 2 February 2001

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Huxley, P., Evans, S., Burns, T. et al. Quality of life outcome in a randomized controlled trial of case management. Soc Psychiatry Psychiatr Epidemiol 36, 249–255 (2001).

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