Latent modelling was used to identify trajectories of depressive symptoms among low-income perinatal women in South Africa. Predictors of trajectories and the association of trajectories with child outcomes were assessed.
This is a secondary analysis of data collected among women living in Cape Town settlements (N = 446). Participants were eligible if pregnant and 18 years or older, and included in the analysis if allocated to the control arm (routine perinatal care). Participants were excluded in case of non-singleton birth and baby death. Follow-up assessments were at 2 weeks, 6-, 18-, and 36-month postpartum. Trajectories of depressive symptoms were based on the Edinburgh Postnatal Depression Scale scores until 18-month postpartum, using latent class growth analysis. Child physical, cognitive, socio-emotional, and behavioural outcomes were assessed at 18 and/or 36 months. Univariate and multivariate regressions were used to identify predictors of trajectories and differences in child outcomes.
Four trajectories were identified: chronic low (71.1%), late postpartum (10.1%), early postpartum (14.4%), and chronic high (4.5%). Low social support, unwanted pregnancy, and risky drinking were associated with the chronic high trajectory; unemployment and HIV-positive status with the early postpartum trajectory; and intimate partner violence with the late postpartum trajectory. Weight-to-length and weight-for-age z-scores at 18 months, and weight-for-age z-scores, length-for-age z-scores, emotional symptom, and peer problem scores at 36 months differed across trajectories.
Severe depressive symptoms in postpartum period have a lasting effect on child physical and socio-emotional outcomes. Multiple screening throughout pregnancy and 1-year postpartum is essential.
Perinatal depression, broadly defined by the World Health Organization (WHO) as major depression occurring during pregnancy and the first postpartum year, is experienced by 13% of women living in low- and middle-income countries (LMICs) . Prevalence in South Africa has consistently been greater, with antenatal depressed mood experienced by 21–39% of women antenatally [2,3,4,5,6,7,8,9,10], and by 24–35% of mothers postnatally. Extensive research has been conducted to document the effects of perinatal depression on children’s health and development, most of which stems from high-income countries (HICs) and concentrates on socio-emotional and cognitive development [11,12,13,14].
In LMICs, evidence has instead largely focused on physical outcomes, such as child physical growth, which is a key indicator of children’s health and nutritional status . This is reasonable, given that, in LMICs, poor growth, malnutrition, and infections are the leading causes of under-five mortality [16, 17]. The majority of evidence comes from South Asia, however, and remains mixed in Sub-Saharan Africa [18, 19]. There is emerging evidence on the impact of perinatal depression on emotional and behavioural development in LMICs . In a South African birth cohort study, there was an association between high maternal depressive symptoms at 6-month postpartum and greater externalising problems among 2-year-old children . However, no associations were found between severe antenatal depressive symptoms and social withdrawal at 10–12-month postpartum among HIV-infected mothers and infants in Cape Town . Finally, an association was found between postnatal depression at 2 months and insecure infant attachment at 18-month postpartum in a study conducted in a peri-urban settlement near Cape Town .
Most studies are cross sectional, however, or include only one assessment of depressive symptoms, thus ignoring the complex and episodic nature of the disorder or the possibility that symptoms are a continuation of pre-pregnancy depression [22, 23]. Such methods have led researchers to ignore the importance of symptom chronicity [14, 25], and instead identify ‘sensitive’ periods, during which depressive symptoms are thought to have especially detrimental effects on child development [13, 24].
Emerging evidence from longitudinal studies in HICs and LMICs indicates that chronicity of depression is more important in predicting poorer child outcomes than are timing or severity of depression [25, 26]. For example, Rotheram-Fuller et al. (2018)’s study in South Africa indicated that there is a greater risk of stunting, and increased internalising and externalising problems among children of mothers with chronic symptoms, but not among mothers, whose symptoms were only present during pregnancy or only postnatally . Chronicity is usually measured as the number of times women screen positive on a depression instrument over the course of a study. Because severe episodes are more likely to last longer, it has been argued that this way of conceptualising chronicity is flawed, as it confounds severity with chronicity [28, 29]. In addition, it relies on an arbitrary cutoff for risk of depression, which can vary by population and measurement tool used.
Studies which have used more complex longitudinal analyses, such as growth curve mixture modelling (GCMM), have enabled the identification of latent subgroups of women with both chronic and transient symptom trajectories during the perinatal period, in both HICs  and LMICs [31, 32]. This allowed investigators to disentangle severity from chronicity and moving away from the dichotomisation of depressive symptoms. Several studies, mostly from HICs, have also made use of this modelling technique to compare child outcomes across different trajectories . Overall, studies indicated that children of mothers experiencing severe or subclinical chronic depressive symptoms were more likely to have developmental problems, compared to children of mothers with severe, but transient, symptoms.
More research is needed in LMICs, where the course of perinatal depressive symptoms and the patterns of risk and resilience among children of mothers with perinatal depression may differ from HICs, given the contexts of food insecurity, HIV, violence, and increased risk of illness among children [14, 15, 34]. The aim of the present study was, therefore, to address this gap. With the use of a person-centred latent approach to identify different depressive symptom trajectories among low-income women in South Africa, this study’s objectives were first to identify predictors of different trajectories, and second, to assess whether children of mothers with different trajectories showed different physical, cognitive, socio-emotional, and behavioural outcomes at 18 and 36 months of age.
This study is a secondary analysis of data collected as part of a cluster randomised controlled trial (RCT) among pregnant women living in peri-urban settlements in Cape Town, South Africa . The aim of the cluster RCT was to assess the effect of a perinatal counselling intervention on a range of maternal and child health and nutrition outcomes. In already published work, the intervention did not have any effect on the participants’ depressive symptoms [36, 37]. However, some differences in child physical outcomes and mothers’ health behaviour were found between the two arms among depressed participants [36, 38, 39]. Therefore, only participants in the control arm were considered in this analysis. Data collection methods were described previously , but are briefly summarised here.
Setting and randomisation
Forty neighbourhoods among three peri-urban settlements were selected as recruitment areas. With the use of aerial maps, street intercept surveys and street observation, 26 neighbourhoods were paired based on several characteristics, such as number of households, distance to an antenatal clinic, type of housing, and sanitation. The remaining neighbourhoods were excluded due to variability on these criteria. Neighbourhoods in matched pairs were randomised into the control or intervention arm using simple randomisation. Of the 13 matched pairs of neighbourhoods, 1 pair was excluded after 6 months due to too few pregnancies being reported (Online Resource 1).
Recruitment and participants
Pregnant women who were 18 years or older were identified by recruiters, local township women familiar with the neighbourhood’s residents, who conducted house-to-house visits and obtained consent from eligible participants to be contacted again. The research team then obtained informed consent and recruited participants from an assessment centre situated locally. Recruitment took place between May 2009 and September 2010.
Due to slow recruitment, late-entry control participants were recruited after giving birth ; these participants did not have antenatal data and so were excluded from the analysis. Participants who gave birth to twins, died or whose baby died during the course of the study were also excluded.
Participants in the control arm did not receive any intervention, besides the standard antenatal and postnatal care provided in the antenatal and well-baby clinics in Cape Town. Assessments were conducted by local women from the community, recruited for this study, trained, certified, and supervised weekly by a clinical psychologist. All data were collected using android devices linked to an online data collection programme. Assessments were conducted in English or isiXhosa, depending on participants’ preferences. Participants were followed-up four times after the baseline assessment: approximately 2 weeks after birth, and at 6-, 18-, and 36-month postpartum. At 18-month postpartum, 8.5% of participants (n = 38) were lost to follow-up; this doubled at 36-month postpartum (n = 73; 16.4%).
Demographic and obstetric characteristics
Self-reported demographic information collected at baseline included age, education, marital, and employment status. Multiple correspondence analysis was employed to create a binary asset-based index of wealth (lower or higher wealth) to use as a proxy for socio-economic status at baseline , based on economic and asset-related measures. Self-reported obstetric measures, such as gestation at recruitment, gravidity, parity, whether the pregnancy was planned or wanted, and previous miscarriages were also collected, and so was HIV status.
The number of friends and relatives the participants had, as well as the frequency of contact, were recorded as a measure of social support at baseline. Whether the participant was living with the father of the baby was also recorded. Finally, participants reporting having been slapped, shoved, punched or threatened with a weapon by their partner in the past 12 months were classified as experiencing physical intimate partner violence (IPV).
Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS; ), a ten-item Likert scale instrument assessing symptoms in the past week. Scores range from 0 to 30, with a greater score suggesting more severe depressive symptoms. This instrument has been validated among antenatal and postnatal women , and among isiXhosa-speaking women [44, 45]. Internal reliability of the EPDS was good at baseline (Cronbach’s α = 0.88).
Alcohol consumption during pregnancy (after discovery) was assessed using the Derived Alcohol Use Disorder Identification Test (AUDIT-C; )—a three-item version of the original ten-item AUDIT . The last item related to the number of times three or more drinks was consumed in one sitting in the past month to reflect the definition of risky drinking for women in South Africa . Scores range from 0 to 12, and a score of three or more is indicative of risky drinking . The AUDIT-C correlates well with the AUDIT , and has been used in previous research among Cape Town’s informal settlements . Internal consistency at baseline was good (α = 0.86).
Physical outcomes were assessed at 18- and 36-month postpartum, by measuring the infant’s length and weight, using scales that were calibrated weekly. These were transformed into z-scores based on age- and gender-adjusted norms .
The motor and cognitive subscales of the Bayley Scales of Infant Toddler Development  were administered at 18 months to assess infants’ cognitive and behavioural outcomes. Scaled scores, adjusted for age, were calculated for each subscale. Children’s executive functioning, including working memory and attention shifting, was assessed at 36-month postpartum using the non-verbal Executive Functioning Battery . This scale consists of three sections: silly sounds (36 questions), something’s the same (28 questions), and operation span (16 questions). Scores for each section were generated by summing all correct responses.
Participants completed two instruments to assess children’s socio-emotional and behavioural outcomes at 36 months: the Child Behaviour Checklist (CBCL; ) and the Strength and Difficulty Questionnaire (SDQ; ). The CBCL is a 99-item 3-point Likert scale questionnaire assessing children’s externalising, internalising, and inattention–hyperactivity problems. The SDQ comprises 25 items measuring conduct and emotional symptoms, hyperactivity and peer relationships, all of which fall under ‘total difficulties’, as well as prosocial behaviour. The SDQ has been translated and used in a previous research in Cape Town among older children and adolescents .
Non-parametric tests were used to compare baseline socio-demographic, obstetric, and health characteristics between participants who were included and excluded from the analyses, and between participants with and without data at 18- and 36-month postpartum (Chi-square and Mann–Whitney U tests, as appropriate). The analysis was then conducted in two steps—first a latent class growth analysis (LCGA), a type of GCMM, in Mplus version 8.0  and a series of multivariate analyses in Stata version 14 .
Identification of classes
With the use of LCGA, EPDS scores from baseline to 18-month postpartum were used to identify latent groups of individuals with similar growth curves (classes) over the extended postpartum period. To reflect the non-equidistant times between assessments , factor loadings were set to 0 (baseline), 0.35 (2-week postpartum), 0.90 (6-month postpartum), and 2.10 (18-month postpartum). Participants completed on average 3.9 assessments (SD 0.50) from baseline to 18-month postpartum. Missing data were assumed to be missing at random and were dealt with full information maximum likelihood estimation within Mplus. A pseudo-maximum likelihood approach (Huber–White sandwich estimator ) was implemented to adjust the estimates’ standard errors for clustering by neighbourhood.
In a preliminary single-class analysis, the quadratic function fits the data significantly better that a linear one . A quadratic polynomial growth function was thus chosen to allow for non-linear trajectories in all subsequent models. The optimal number of classes for the final model was chosen by comparing models with different numbers of classes according to the Bayesian and Akaike Information Criteria [61, 62], the entropy , and the average probability of class membership (posterior probability). The Lo–Mendel–Rubin test (LMRT)  and Bootstrap Likelihood Ratio Test (BLRT)  were also used to test the difference in fit between successive models. Finally, the size and theoretical interpretability of classes were also considered. After fitting the final model, participants were assigned to latent classes based on their highest posterior probability.
Predictors and outcomes of trajectories
To identify predictors of trajectories generated through the LCGA, a series of univariate unadjusted multinomial logistic regressions were conducted, with class membership as outcome, and baseline socio-demographic, obstetric and health characteristics as predictors. Class membership was then entered as a predictor in linear and logistic regressions to assess continuous and binary child outcomes, respectively, at 18 and 36 months. Each of these models were adjusted for age, education and wealth status, factors shown to be confounders in the relationship between maternal depression and child outcomes [15, 63,64,68]. To avoid reporting bias due to concurrent depressive symptoms, known to affect maternal reports of child behaviour [11, 69], models assessing maternal reports of child outcomes at 36 months were adjusted for participants’ EPDS score. This was not necessary for child outcomes at 18 months, however, since the EPDS was used to generate the latent trajectories of depressive symptoms.
The cluster RCT was approved by the Institutional Review Boards of the University of California Los Angeles (G07-02-022) and Stellenbosch University Institutional Review Board (N08/08/218). This study was approved by the University of Cape Town (HREC REF 835/2015).
A total of 594 pregnant women were recruited from 12 control arm neighbourhoods, each comprising 20–60 participants. After excluding late-entry participants (n = 94), and participants who gave birth to twins (n = 2), who died or whose baby died during the study (from baseline to 18-month postpartum; n = 52), the final sample was 446 (Online Resource 1). Participants excluded from the analyses were recruited earlier in pregnancy (median, Mdn 17.5 weeks, interquartile range, IQR 13–26) and reported higher EPDS scores at baseline (Mdn 13, IQR 7–19), compared to those included (gestation: Mdn 27.5 weeks, IQR 21–34, p < 0.001; EPDS: Mdn 10, IQR 5–16, p = 0.011).
Baseline characteristics of the final sample are presented in Table 1. Participants had a mean age of 26 years (standard deviation, SD 5.30), and were recruited, on average, at 26.6-week gestation (SD 8.03), corresponding to the 6th month of gestation. Only a minority reported completing high school (n = 110, 24.7%), working (n = 83, 18.6%), and not having a partner (n = 27, 6.1%). Over a third (n = 174, 39.0%) reported having experienced IPV in the previous year and 26.2% (n = 107) reported being HIV-positive at baseline.
Compared to participants who were followed-up, participants lost to follow-up (n = 38, 8.5%) reported lower baseline EPDS scores (Mdn 6, IQR 2–12 vs. Mdn 10, IQR 5–16, U = 2.79, p = 0.005) and the majority were from the lower wealth category (n = 26, 68.4% vs. n = 197, 48.3%, χ2 = 5.64, p = 0.026). At 36-month postpartum, a greater proportion of participants lost to follow-up (n = 73, 16.4%) were from the lower wealth category (n = 46, 63.0 vs. n = 177, 47.5%, χ2 = 5.91, p = 0.021), and a smaller proportion reported experiencing IPV (n = 21, 28.8% vs. n = 153, 41.0%, χ2 = 3.85, p = 0.050).
The LCGA indices led to a four-class model (Table 2), which had the highest entropy (0.963) and fit significantly better than a three-class model, according to the LMRT and BLRT values (Table 2). The smallest class included 4.5% of the sample (n = 20). The change in mean EPDS scores over time among women in each of the four classes (Fig. 4.2) suggests a combination of chronic and transient symptom trajectories: (1) chronic low trajectory (n = 317, 71.1%), with a highest mean EPDS score at baseline (mean 9.9, SD 6.54), which steadily decreases; (2) late postpartum trajectory (n = 45, 10.1%), with a slightly higher baseline mean score which increases sharply to 22.1 (SD 1.95) at 18-month postpartum; (3) early postpartum trajectory (n = 65, 14.4%), with a mean baseline scores just above the severity cutoff of 13 , which reaches a maximum mean score of 22.3 (SD 3.6) at 6-month postpartum and declines to very low levels at 18-month postpartum; and (4) chronic high trajectory (n = 20, 4.5%), with a mean baseline score of 15.7 (SD 6.96), which increases steadily to 22.5 (SD 3.79) at 6 months and stabilises (Fig. 1).
The results of the univariate multinomial logistic regressions to assess baseline predictors of trajectories are presented in Table 3. The chronic low trajectory was used as the reference category. The risk of belonging to the chronic high trajectory, vs. the chronic low trajectory, among those who reported below average social support, an unwanted pregnancy and risky drinking was 3.43 (95% CI 1.22, 9.65), 3.82 (95% CI 1.00, 14.57) and 3.82 (95% CI 1.00, 14.57) times as high, respectively, as the risk of belonging to this trajectory when these characteristics were not reported. The risk of belonging to the early postpartum trajectory among those who were unemployed and those who were HIV-positive was 8.95 (95% CI 2.14, 37.48) and 2.13 (95% CI 1.17, 3.88) times as high as the risk of belonging to this trajectory when participants reported being employed and HIV negative, respectively. The risk of belonging to the late postpartum trajectory among those who reported IPV in the year preceding recruitment was 1.91 (95% CI 1.02, 3.59) times as high as the risk of belonging to this trajectory when no IPV was reported.
The results of the linear and logistic regressions assessing child outcomes at 18 and 36 months in relation with the trajectories, adjusted for age, education and wealth, are presented in Table 4. Again, the chronic low trajectory was used as the reference trajectory.
Children of participants allocated to the late postpartum trajectory had significantly lower weight-to-length (mean 0.11, SD 1.36) and weight-for-age z-scores (mean − 0.22, SD 1.09) compared to children of participants in the chronic low trajectory (weight-to-length z-score: mean 0.91, SD 1.33; adjusted β (aβ) − 0.81; 95% CI − 1.27, − 0.34; weight-for-age z-scores: mean 0.41, SD 1.22, aβ − 0.63; 95% CI − 1.05, − 0.21). The same pattern could be seen among children of participants allocated to the early postpartum trajectory, with children reporting lower weight-to-length (mean 0.36, SD 1.33, aβ − 0.52; 95% CI − 0.92, − 0.11) and weight-to-age z-scores (mean − 0.09, SD 1.23; aβ − 0.45; 95% CI − 0.81, − 0.09) compared to children of participants in the chronic low trajectory.
Results indicate that children of participants in the late postpartum trajectory had lower weight-for-age z-scores (mean − 0.20, SD 0.99) compared to children of participants allocated to the chronic low trajectory (mean 0.23, SD 1.09; aβ − 0.43; 95% CI − 0.78, − 0.07). Children of participants in the early postpartum trajectory reported significantly lower length-for-age (mean − 1.83, SD 1.07, aβ − 0.55; 95% CI − 0.90, − 0.21) and weight-for-age z-scores (mean − 0.34, SD 0.94; aβ − 0.54; 95% CI − 0.87, − 0.21).
Scores on the executive functioning battery did not differ across trajectories. There were also no differences in internalising, externalising or total problem scores on the CBCL, nor differences in total difficulty score on the SDQ. However, children of participants in the chronic high trajectory reported greater emotional symptom scores (mean 2.2, SD 2.66), and children of participants in the late postpartum trajectory had greater peer problem scores (mean 3.0, SD 1.26), compared to children in the chronic low trajectory (emotional: mean 1.1, SD 1.47, aβ 0.96; 95% CI 0.17, 1.75; peer problems: mean 2.6, SD 1.13, aβ 0.42 95% CI 0.0.02, 0.81). Finally, children of participants in the early postpartum trajectory (mean 8.2, SD 1.62; aβ 0.85; 95% CI 0.21, 1.50) and in the chronic high trajectory (mean 8.5, SD 1.5; aβ 1.19; 95% CI 0.14, 2.24) reported greater SDQ prosocial scores compared to children of participants in the chronic low trajectory (mean 7.5, SD 2.22).
This study sought to identify latent trajectories of depressive symptoms from pregnancy to 18-month postpartum, and their predictors, among low-income perinatal women in South Africa. Altogether, the four trajectories identified support previous findings using similar modelling techniques [30, 33]. First, the chronic low trajectory identified was reported in a previous study conducted in Africa , suggesting that, despite the high number and ongoing stressors experienced in LMICs, the majority of women remain at low risk of developing depressive symptoms during the perinatal period. Second, the early postpartum and late postpartum trajectories identified are also similar to those reported by Barthel et al. . In their study conducted among perinatal women in Ghana and Côte d’Ivoire, they report that besides family and financial stress, none of the socio-demographic or psychosocial factors were associated with these trajectories. Findings were similar in our study: only IPV in the year leading to pregnancy was identified as a risk factor for late postpartum depressive symptoms, and unemployment and HIV-positive status as risk factors for early postpartum depressive symptoms. The latter finding corroborates past research in South Africa indicating that being diagnosed with HIV during pregnancy can put mothers at increased risk of postnatal depression . The practical implications of inadequate resources to provide for a new baby, once the baby is born, could also explain the association found between unemployment and the early postpartum trajectory . Finally, women with chronically severe symptoms, reported in the previous research in South Africa , seem to be a high-risk group, as they reported having less social support, were more likely to report an unwanted pregnancy and more likely to have been engaging in risky drinking behaviour during pregnancy. Likewise, the high-risk antenatal and postnatal trajectory in Baron et al. ’s study was associated with lower social support and heavy drinking during pregnancy.
The fact that two of the four trajectories identified have transient patterns indicate that a single screening for depressive symptoms may not be enough to identify women at risk of perinatal depression. Instead, repeated screening conducted throughout pregnancy and the first year postpartum would be more effective, perhaps in the context of antenatal and well-baby visits. Alternatively, and as our findings suggest, screening for other factors, such as lack of social support, alcohol use and IPV, in antenatal settings may be a way of identifying pregnant women who may be at risk of chronic symptoms or of worse symptoms later in the postpartum period.
The second aim of our study was to investigate the association between trajectories of perinatal depression symptoms and child outcomes at 18- and 36-month postpartum. Important distinctions were found in children’s physical outcomes across trajectories, and this even after controlling for known demographic confounders, including wealth, suggesting that poorer physical outcomes were not solely due to children’s social or economic environment. In addition, the fact that weight-to-length z-scores, a short-term response to inappropriate nutrition , and length-for-age z-scores, a longer term cumulative response to poor diet and recurrent illness , were lower at 18 and 36 months, respectively, among children of mothers in the early postpartum trajectory suggest that the effect of postnatal depressive symptoms may have long-lasting effects on child physical outcomes. Emerging evidence suggests that psychosocial interventions for depression which include parenting or caregiving components are the most effective in improving both maternal mental health and child outcomes . Given the impact of depressive symptoms on children’s physical outcomes in this study, it may be worth including a nutritional advice component in psychosocial interventions addressing perinatal depressive symptoms.
Surprisingly, the motor or cognitive outcomes of infants at 18 months, and executive functioning at 36 months, thought to be an indicator of learning disability even when cognitive abilities seem intact , did not differ across depressive symptom trajectories. There were also no differences in overall socio-emotional or behavioural outcomes on the SDQ or CBCL questionnaires at 36-month postpartum. However, the investigation of the SDQ subscales indicated that children of mothers with chronically high symptoms had greater emotional symptom problems, and children of mothers among the late postpartum trajectory had greater peer-related problems, compared to children of mothers with low depressive symptoms. This corroborates Vänskä et al. (2011)’s study, where no differences in externalising symptoms could be found across different trajectories of depression, but children of mothers with chronically high symptoms showed greater internalising symptoms compared to children of mothers with stable low symptoms.
As suggested by Prenoveau et al. , it may be that mothers’ low positive affect may be more detrimental to children’ emotional negativity specifically. However, the previous studies using similar modelling techniques did find that children of mothers with chronic or transient depressive symptoms reported poorer executive functioning and greater emotional and behavioural problems [71,72,76]. These studies were conducted in HICs, however, and the impact of depressive symptoms on children’s development may differ in LMICs, where social and psychological factors, such as poverty and cultural norms, are likely to play an important role. It was beyond the scope of this study to investigate moderating or mediating factors of child development; however, future research in LMICs should to further our understanding of the underlying mechanisms between maternal depression and child development.
Several limitations should be noted. First, while LCGA overcomes some of past research’s pitfalls, assessments were still limited and wide apart. Our interpretation of ‘chronic’ symptoms, therefore, remains simplistic. With only one assessment conducted during pregnancy, we cannot assess whether symptoms fluctuated during pregnancy, or whether they were a continuation of pre-pregnancy symptoms. In addition, the second assessment was conducted within the first 2-week postpartum, so depressive symptoms may have reflected baby blues, rather than postnatal depression per se. Moreover, the EPDS is a valid measure of depressive symptoms during the perinatal period, but the exclusion of somatic symptoms means that it may not be valid at 18- or 36-month postpartum. The potential underestimation of depressive symptom severity at these assessments may have affected the 18-month mark of trajectories identified through LCGA. It may also have led to underestimate the effect of depressive symptoms on mothers’ reports of child development at 36 months, which was controlled for in the analysis. This may partly explain the lack of association between depressive symptoms trajectories and behavioural outcomes.
A further limitation relating to the use of LCGA is that it assumes no intra-class variance in the growth parameters, which may have been too restrictive. However, allowing free variance for the intercepts produced a negligible improvement in fit and no substantive changes in the shape of the trajectories or in the overall distribution of the sample across classes. Models also did not converge when free variance was allowed for the slope and quadratic terms (i.e., moving from LCGA to growth mixture modelling). While this could be due to an insufficient sample size, this may reflect the absence of significant variability, suggesting that LCGA may be an appropriate method to model our data nonetheless.
The little intra-class variability also supports the four-class model identified, despite the small sample size of the chronic high trajectory. However, a small sample size meant that we may not have had enough power to identify meaningful differences between trajectories, especially between the chronic high and low trajectories. A small sample size also meant that univariate, rather than multivariate, analyses of risk factors were more appropriate. However, though not reported here, the patterns of risk for each trajectory did not change substantially when multivariate analyses of risk factors were conducted despite the presence of broad confidence intervals.
Finally, all analyses conducted in Stata to assess predictors and child outcomes considered class membership as observed, rather than predicted by the LCGA model. However, given the high classification accuracy showed by our four-class model, it is unlikely that taking into account this uncertainty in regression models would have produced substantive changes in the interpretation of the results.
To our knowledge, this is the first study in Sub-Saharan Africa to have used GCMM to assess the course of perinatal depressive symptoms in relation with child development. Despite several limitations, our study has clear implications for the identification of at-risk populations and for the development of preventive interventions to promote maternal mental health and child development. Mothers remain at risk for developing severe symptoms after 1-year postpartum, and while several psychosocial factors can help identify pregnant women likely to suffer from chronic or late postpartum depression, policy makers and practitioners must recognise the need for multiple screening assessments throughout pregnancy and the first year postpartum.
Our study does not support the idea that there are sensitive periods in which maternal depressive symptoms have qualitatively different impact on children’s development. Instead, it seems the presence of depressive symptoms at any point during the perinatal period can have adverse effects on children’s physical and socio-emotional outcomes. Further investigation in LMICs is warranted, with bigger samples and more frequent assessments. This will help tease out the relative importance of chronicity of symptoms vs. severity, identify whether antenatal and postnatal depressive symptoms have independent or interactive effects on child outcomes, and work towards identifying pathways between perinatal depression and child outcomes that are specific to LMICs.
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We would like to acknowledge Dr. Sujit Rathod, who provided insights into post-hoc analyses, and Ellen Almirol for providing support with access to the study materials and datasets. This study is an output of the PRogramme for Improving Mental health carE (PRIME). This work was supported by the UK Department for International Development (201446). The views expressed do not necessarily reflect the UK Government’s official policies.
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent was given by all participants before their inclusion in the study. Personal details of participants were omitted from the data. The original cluster randomised controlled trial was approved by the Institutional Review Boards of the UCLA (G07-02-022) and Stellenbosch University Institutional Review Board (N08/08/218). This study was approved by the University of Cape Town (HREC REF 835/2015).
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Garman, E.C., Cois, A., Tomlinson, M. et al. Course of perinatal depressive symptoms among South African women: associations with child outcomes at 18 and 36 months. Soc Psychiatry Psychiatr Epidemiol 54, 1111–1123 (2019). https://doi.org/10.1007/s00127-019-01665-2
- Latent class growth analysis
- Child development