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Fig. 4 | Diabetologia

Fig. 4

From: Early nerve fibre regeneration in individuals with type 1 diabetes after simultaneous pancreas and kidney transplantation

Fig. 4The alternative text for this image may have been generated using AI.

Representative examples of 50 μm skin biopsy sections immunostained for (a–d) PGP9.5 and (e–h) GAP-43 from a healthy control participant (a, e) and an SPK patient (b–d, f–h) . (a) The healthy control sample shows numerous long branching intraepidermal nerve fibres (IENFs) reaching the upper epidermis and a well-developed subepidermal nerve plexus. IENFs in an SPK patient at baseline (b) are sparse and short, showing (c) elongation and (d) branching after 12 months. Red arrows indicate nerves crossing the basement membrane and blue arrows show the terminal part of the IENF. (e) GAP-43 immunostained nerve fibres from the same healthy individual as in (a) are long and branching and those from an SPK patient at baseline (f) and at 12 (g) and 24 (h) months after SPK show a similar pattern as those stained for PGP9.5. Scale bars in (a) and (e), 50 μm; scale bars in (b–d) and (f–h), 25 μm

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