Diabetologia

, Volume 60, Issue 12, pp 2529–2531 | Cite as

Lower corneal nerve fibre length identifies diabetic neuropathy in older adults with diabetes: results from the Canadian Study of Longevity in Type 1 Diabetes

  • Daniel Scarr
  • Leif E. Lovblom
  • Julie A. Lovshin
  • Geneviève Boulet
  • Mohammed A. Farooqi
  • Andrej Orszag
  • Alanna Weisman
  • Nancy Cardinez
  • Yuliya Lytvyn
  • Mylan Ngo
  • Hillary A. Keenan
  • Michael H. Brent
  • Narinder Paul
  • Vera Bril
  • David Z. I. Cherney
  • Bruce A. Perkins
Research Letter

Keywords

Corneal confocal microscopy Corneal nerve fibre length Diabetic neuropathy Type 1 diabetes 

Abbreviations

CNBD

Corneal nerve branch density

CNFD

Corneal nerve fibre density

CNFL

Corneal nerve fibre length

IVCCM

In vivo corneal confocal microscopy

ROC

Receiver operating characteristic

ROC-AUC

Area under the ROC curve

References

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    Ziegler D, Luft D (2002) Clinical trials for drugs against diabetic neuropathy: can we combine scientific needs with clinical practicalities? Int Rev Neurobiol 50:431–463CrossRefPubMedGoogle Scholar
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    Boulton AJ, Kempler P, Ametov A, Ziegler D (2013) Whither pathogenetic treatments for diabetic polyneuropathy? Diabetes Metab Res Rev 29:327–333CrossRefPubMedGoogle Scholar
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    Breiner A, Lovblom LE, Perkins BA, Bril V (2014) Does the prevailing hypothesis that small-fiber dysfunction precedes large-fiber dysfunction apply to type 1 diabetic patients? Diabetes Care 37:1418–1424CrossRefPubMedGoogle Scholar
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    Ahmed A, Bril V, Orszag A et al (2012) Detection of diabetic sensorimotor polyneuropathy by corneal confocal microscopy in type 1 diabetes: a concurrent validity study. Diabetes Care 35:821–828CrossRefPubMedPubMedCentralGoogle Scholar
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    Tavakoli M, Quattrini C, Abbott C et al (2010) Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care 33:1792–1797CrossRefPubMedPubMedCentralGoogle Scholar
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    Tavakoli M, Ferdousi M, Petropoulos IN et al (2015) Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Diabetes Care 38:838–843CrossRefPubMedPubMedCentralGoogle Scholar
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    Bai JW, Lovblom LE, Cardinez M et al (2017) Neuropathy and presence of emotional distress and depression in longstanding diabetes: results from the Canadian study of longevity in type 1 diabetes. J Diabetes Complications 31:1318–1324CrossRefPubMedGoogle Scholar
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    Tavakoli M, Malik RA (2011) Corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J Vis Exp 3:2194Google Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Daniel Scarr
    • 1
  • Leif E. Lovblom
    • 1
  • Julie A. Lovshin
    • 2
    • 3
  • Geneviève Boulet
    • 1
  • Mohammed A. Farooqi
    • 1
  • Andrej Orszag
    • 1
  • Alanna Weisman
    • 1
    • 3
  • Nancy Cardinez
    • 1
  • Yuliya Lytvyn
    • 2
  • Mylan Ngo
    • 4
  • Hillary A. Keenan
    • 5
  • Michael H. Brent
    • 6
  • Narinder Paul
    • 7
  • Vera Bril
    • 4
  • David Z. I. Cherney
    • 2
  • Bruce A. Perkins
    • 1
    • 3
  1. 1.Lunenfeld-Tanenbaum Research Institute, Leadership Sinai Centre for DiabetesMount Sinai HospitalTorontoCanada
  2. 2.Division of Nephrology, Department of MedicineUniversity of TorontoTorontoCanada
  3. 3.Division of Endocrinology and Metabolism, Department of MedicineUniversity of TorontoTorontoCanada
  4. 4.The Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Krembil Neuroscience Centre, Division of Neurology, Department of MedicineUniversity Health Network, University of TorontoTorontoCanada
  5. 5.Research Division, Joslin Diabetes CenterBostonUSA
  6. 6.Department of Ophthalmology and Vision Sciences, Department of MedicineUniversity of TorontoTorontoCanada
  7. 7.Joint Department of Medical Imaging, Division of Cardiothoracic RadiologyUniversity Health NetworkTorontoCanada

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