Diabetologia

, Volume 60, Issue 12, pp 2529–2531 | Cite as

Lower corneal nerve fibre length identifies diabetic neuropathy in older adults with diabetes: results from the Canadian Study of Longevity in Type 1 Diabetes

  • Daniel Scarr
  • Leif E. Lovblom
  • Julie A. Lovshin
  • Geneviève Boulet
  • Mohammed A. Farooqi
  • Andrej Orszag
  • Alanna Weisman
  • Nancy Cardinez
  • Yuliya Lytvyn
  • Mylan Ngo
  • Hillary A. Keenan
  • Michael H. Brent
  • Narinder Paul
  • Vera Bril
  • David Z. I. Cherney
  • Bruce A. Perkins
Research Letter

Keywords

Corneal confocal microscopy Corneal nerve fibre length Diabetic neuropathy Type 1 diabetes 

Abbreviations

CNBD

Corneal nerve branch density

CNFD

Corneal nerve fibre density

CNFL

Corneal nerve fibre length

IVCCM

In vivo corneal confocal microscopy

ROC

Receiver operating characteristic

ROC-AUC

Area under the ROC curve

Notes

Acknowledgements

This research was supported by Diabetes Canada and the JDRF Canadian Clinical Trial Network, as well as R. and J. Frisch and The Harvey and Annice Frisch Family Fund.

Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Funding

This research was funded by the JDRF Canada (17-2013-312).

Duality of interest

JAL has received speaker honoraria from Novo Nordisk, Merck Sharp & Dohme, Eli Lilly, Intarcia Therapeutics and AstraZenca. GB has received speaker honoraria from Johnson & Johnson. HAK has received support from Sanofi. NP has received support from Toshiba Medical. DZIC has received speaker honoraria from Janssen, AstraZeneca, Boehringer Ingelheim, Eli Lilly and Merck Sharp & Dohme and has received research grant support from AstraZeneca, Merck Sharp & Dohme and Boehringer Ingelheim. BAP has received speaker honoraria from Medtronic, Johnson & Johnson, Roche, GlaxoSmithKline Canada, Novo Nordisk and Sanofi; has received research grant support from Medtronic and Boehringer Ingelheim; and serves as a consultant for NeuroMetrix.

Contribution statement

All authors were involved in revising the manuscript critically for important intellectual content and for final approval of the version to be published. DS contributed to conception and design of the study, acquisition of data, analysis and interpretation of data and wrote the manuscript. LEL contributed to conception and design of the study and analysis and interpretation of the data. JAL, GB, MAF, AO, and MN contributed to acquisition of data. AW, NC, YL, HAK, MHB, NP, and VB contributed to analysis and interpretation of data. DZIC and BAP contributed to conception and design of the study and analysis and interpretation of data. BAP is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity and accuracy of the data and analysis.

References

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Daniel Scarr
    • 1
  • Leif E. Lovblom
    • 1
  • Julie A. Lovshin
    • 2
    • 3
  • Geneviève Boulet
    • 1
  • Mohammed A. Farooqi
    • 1
  • Andrej Orszag
    • 1
  • Alanna Weisman
    • 1
    • 3
  • Nancy Cardinez
    • 1
  • Yuliya Lytvyn
    • 2
  • Mylan Ngo
    • 4
  • Hillary A. Keenan
    • 5
  • Michael H. Brent
    • 6
  • Narinder Paul
    • 7
  • Vera Bril
    • 4
  • David Z. I. Cherney
    • 2
  • Bruce A. Perkins
    • 1
    • 3
  1. 1.Lunenfeld-Tanenbaum Research Institute, Leadership Sinai Centre for DiabetesMount Sinai HospitalTorontoCanada
  2. 2.Division of Nephrology, Department of MedicineUniversity of TorontoTorontoCanada
  3. 3.Division of Endocrinology and Metabolism, Department of MedicineUniversity of TorontoTorontoCanada
  4. 4.The Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Krembil Neuroscience Centre, Division of Neurology, Department of MedicineUniversity Health Network, University of TorontoTorontoCanada
  5. 5.Research Division, Joslin Diabetes CenterBostonUSA
  6. 6.Department of Ophthalmology and Vision Sciences, Department of MedicineUniversity of TorontoTorontoCanada
  7. 7.Joint Department of Medical Imaging, Division of Cardiothoracic RadiologyUniversity Health NetworkTorontoCanada

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