Lower corneal nerve fibre length identifies diabetic neuropathy in older adults with diabetes: results from the Canadian Study of Longevity in Type 1 Diabetes
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KeywordsCorneal confocal microscopy Corneal nerve fibre length Diabetic neuropathy Type 1 diabetes
Corneal nerve branch density
Corneal nerve fibre density
Corneal nerve fibre length
In vivo corneal confocal microscopy
Receiver operating characteristic
Area under the ROC curve
This research was supported by Diabetes Canada and the JDRF Canadian Clinical Trial Network, as well as R. and J. Frisch and The Harvey and Annice Frisch Family Fund.
The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
This research was funded by the JDRF Canada (17-2013-312).
Duality of interest
JAL has received speaker honoraria from Novo Nordisk, Merck Sharp & Dohme, Eli Lilly, Intarcia Therapeutics and AstraZenca. GB has received speaker honoraria from Johnson & Johnson. HAK has received support from Sanofi. NP has received support from Toshiba Medical. DZIC has received speaker honoraria from Janssen, AstraZeneca, Boehringer Ingelheim, Eli Lilly and Merck Sharp & Dohme and has received research grant support from AstraZeneca, Merck Sharp & Dohme and Boehringer Ingelheim. BAP has received speaker honoraria from Medtronic, Johnson & Johnson, Roche, GlaxoSmithKline Canada, Novo Nordisk and Sanofi; has received research grant support from Medtronic and Boehringer Ingelheim; and serves as a consultant for NeuroMetrix.
All authors were involved in revising the manuscript critically for important intellectual content and for final approval of the version to be published. DS contributed to conception and design of the study, acquisition of data, analysis and interpretation of data and wrote the manuscript. LEL contributed to conception and design of the study and analysis and interpretation of the data. JAL, GB, MAF, AO, and MN contributed to acquisition of data. AW, NC, YL, HAK, MHB, NP, and VB contributed to analysis and interpretation of data. DZIC and BAP contributed to conception and design of the study and analysis and interpretation of data. BAP is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity and accuracy of the data and analysis.
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