Diabetologia

, Volume 60, Issue 12, pp 2525–2528 | Cite as

South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men

  • Andrea D. van Dam
  • Mark J. W. Hanssen
  • Robin van Eenige
  • Edwin Quinten
  • Hetty C. Sips
  • Cindy J. M. Hülsman
  • Ingrid M. Jazet
  • Wouter D. van Marken Lichtenbelt
  • Tom H. M. Ottenhoff
  • Mariëlle C. Haks
  • Patrick C. N. Rensen
  • Mariëtte R. Boon
Research Letter

Keywords

Inflammation Interferon signalling Skeletal muscle South Asians Type 2 diabetes White adipose tissue 

Abbreviations

CXCL10

Chemokine (C-X-C) motif ligand 10

IPA

Ingenuity pathway analysis

WAT

White adipose tissue

Supplementary material

125_2017_4427_MOESM1_ESM.pdf (557 kb)
ESM(PDF 556 kb)
125_2017_4427_MOESM2_ESM.xlsx (107 kb)
ESM Table 3(XLSX 106 kb)

References

  1. 1.
    Raji A, Seely EW, Arky RA, Simonson DC (2001) Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 86:5366–5371CrossRefPubMedGoogle Scholar
  2. 2.
    Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121:2111–2117CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Haks MC, Goeman JJ, Magis-Escurra C, Ottenhoff TH (2015) Focused human gene expression profiling using dual-color reverse transcriptase multiplex ligation-dependent probe amplification. Vaccine 33:5282–5288CrossRefPubMedGoogle Scholar
  4. 4.
    Wieser V, Adolph TE, Grander C et al (2016) Adipose type I interferon signalling protects against metabolic dysfunction. Gut https://doi.org/10.1136/gutjnl-2016-313155
  5. 5.
    Burke JD, Platanias LC, Fish EN (2014) Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3. J Virol 88:3485–3495CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Alsaggar M, Mills M, Liu D (2016) Interferon beta overexpression attenuates adipose tissue inflammation and high-fat diet-induced obesity and maintains glucose homeostasis. Gene Ther 24:60–66CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Andrea D. van Dam
    • 1
    • 2
  • Mark J. W. Hanssen
    • 3
  • Robin van Eenige
    • 1
    • 2
  • Edwin Quinten
    • 4
  • Hetty C. Sips
    • 1
    • 2
  • Cindy J. M. Hülsman
    • 3
  • Ingrid M. Jazet
    • 1
  • Wouter D. van Marken Lichtenbelt
    • 3
  • Tom H. M. Ottenhoff
    • 4
  • Mariëlle C. Haks
    • 4
  • Patrick C. N. Rensen
    • 1
    • 2
  • Mariëtte R. Boon
    • 1
    • 2
    • 3
  1. 1.Department of Medicine, Division of Endocrinology, post zone C7QLeiden University Medical CenterLeidenthe Netherlands
  2. 2.Einthoven Laboratory for Experimental Vascular MedicineLeidenthe Netherlands
  3. 3.Department of Human Biology & Human Movement SciencesMaastricht University Medical CenterMaastrichtthe Netherlands
  4. 4.Department of Infectious DiseasesLeiden University Medical CenterLeidenthe Netherlands

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