South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men
To the Editor: South Asians, who originate from the Indian subcontinent, make up 20% of the global population and have a higher risk of developing type 2 diabetes compared with white Europids . Albeit central obesity and insulin resistance are more prevalent in the South Asian population , these classic predisposing risk factors cannot fully explain the excess risk of developing type 2 diabetes. Inflammation is thought to play a role in obesity-associated metabolic disorders but our understanding of the mechanisms involved is still limited . Despite the high risk of type 2 diabetes in South Asian people and increasing evidence on the links between inflammation and the development of type 2 diabetes, comprehensive data on the inflammatory state in the South Asian population are lacking. Therefore, the aim of the current study was to compare transcriptomic levels of a large panel of inflammatory, immune regulating and immune cell subset markers in the blood, skeletal muscle and...
KeywordsInflammation Interferon signalling Skeletal muscle South Asians Type 2 diabetes White adipose tissue
Chemokine (C-X-C) motif ligand 10
Ingenuity pathway analysis
White adipose tissue
We thank C. van der Bent and TCM Streefland (Department of Medicine, Division of Endocrinology, LUMC, Leiden, the Netherlands) for their excellent technical assistance. The study was originally designed and implemented by MRB and MJWH to assess the effect of l-arginine on energy expenditure and mitochondrial function, for which a part of this study will be published elsewhere.
The data generated or analysed during the current study that are not included in this published article (and its supplementary information files) are available from the corresponding author on reasonable request. Raw data from the dual-colour reverse transcriptase multiplex ligation-dependent probe amplification (dcRT-MLPA) assay are provided in ESM Table 3.
This work was supported by a Rembrandt Institute of Cardiovascular Science (RICS) grant and a Rubicon grant from the Netherlands Organisation for Scientific Research to MRB. MRB is also supported by the Dutch Diabetes Foundation (grant no. 2015.81.1808). PCNR is an Established Investigator of the Netherlands Heart Foundation (grant no. 2009T038).
Duality of interest
The authors declare no potential conflicts of interest relevant to this article.
ADvD helped to conceptualise the project, perform the experiments and analyse the data, contributed to the discussion, wrote and critically reviewed the manuscript. MJWH helped to perform the experiments, analyse the data and critically reviewed the manuscript. RvE, EQ, HCS, CJMH, THMO and MCH helped to perform the experiments, analyse the data and critically review the manuscript. IMJ and WDvML helped to conceptualise the project and to critically review the manuscript. PCNR and MRB helped to conceptualise the project and perform the experiments, supervised the project, contributed to the discussion and edited the manuscript. All authors gave approval for the final version to be published. ADvD, MJWH, PCNR and MRB are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
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