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Diabetologia

, Volume 55, Issue 3, pp 542–551 | Cite as

What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review

  • M. Chimen
  • A. Kennedy
  • K. Nirantharakumar
  • T. T. Pang
  • R. Andrews
  • P. NarendranEmail author
Review

Abstract

Physical activity improves well-being and reduces the risk of heart disease, cancer and type 2 diabetes mellitus in the general population. In individuals with established type 2 diabetes, physical activity improves glucose and lipid levels, reduces weight and improves insulin resistance. In type 1 diabetes mellitus, however, the benefits of physical activity are less clear. There is poor evidence for a beneficial effect of physical activity on glycaemic control and microvascular complications, and significant risk of harm through hypoglycaemia. Here we review the literature relating to physical activity and health in type 1 diabetes. We examine its effect on a number of outcomes, including glycaemic control, lipids, blood pressure, diabetic complications, well-being and overall mortality. We conclude that whilst there is sufficient evidence to recommend physical activity in the management of type 1 diabetes, it is still unclear as to what form, duration and intensity should be recommended and whether there is benefit for many of the outcomes examined.

Keywords

Complications Glycaemic control HbA1c Physical activity Review Type 1 diabetes 

Abbreviations

CVD

Cardiovascular disease

BMD

Bone mineral density

\( \dot{V}{{\text{O}}_{\text{2max}}} \)

Maximal aerobic capacity

Introduction

Physical activity reduces the risk of coronary heart disease, stroke, osteoporosis, and colon and breast cancer in the general population [1]. There is also evidence that physical activity reduces obesity, osteoarthritis, lower back pain and clinical depression and improves mental well-being in this population. With regard to type 2 diabetes, randomised controlled trials have demonstrated that physical activity can delay the progression of impaired glucose tolerance to type 2 diabetes when combined with changes to the diet [2]. In patients with established type 2 diabetes, physical activity improves glycaemic control and reduces medication dose, weight and cardiovascular risk factors [3].

In light of this evidence, diabetes organisations strongly advocate a role for physical activity in the management of diabetes [4, 5]. Much of the advice relates to type 2 diabetes. The ADA suggests that ‘persons with type 2 diabetes should undertake at least 150 min per week of moderate to vigorous aerobic exercise spread out during at least 3 days during the week, with no more than two consecutive days between bouts of aerobic activity. Aerobic exercise should be at least at moderate intensity, corresponding approximately to 40–60% of \( \dot{V}{{\text{O}}_{\text{2max}}} \) (maximal aerobic capacity). For most people with type 2 diabetes, brisk walking is a moderate-intensity exercise. Additional benefits may be gained from vigorous exercise (>60% of \( \dot{V}{{\text{O}}_{\text{2max}}} \))’ [4]. The benefits of resistance exercise have also recently been recognised [6], and the ADA suggests that patients with type 2 diabetes should be encouraged to perform resistance exercise ‘at least twice weekly on non consecutive days, but more ideally three times a week, as part of a physical activity program for individuals with type 2 diabetes, along with regular aerobic activities. Each training session should minimally include five to ten exercises involving the major muscle groups (in the upper body, lower body, and core) and involve completion of 10–15 repetitions to near fatigue per set early in training, progressing over time to heavier weights (or resistance) that can be lifted only eight to ten times. A minimum of one set of repetitions to near fatigue, but as many as three to four sets, is recommended for optimal strength gains’ [4]. There is also guidance on type 1 diabetes stating that all levels of exercise can be performed, and providing guidelines for safe exercise [7, 8].

The weight of evidence for the benefits of physical activity in patients with type 2 diabetes, whilst by no means satisfactory, still exceeds that available for type 1 diabetes. Much of the guidelines applied to patients with type 1 diabetes are based on understanding gained from studies on individuals without diabetes or with type 2 diabetes, both clearly very different conditions. Furthermore, whilst there is evidence that (young and complication-free) patients with type 1 diabetes undertake as much physical activity as people without diabetes, these levels remain suboptimal [9, 10]. There is also a further group of patients who report fear of hypoglycaemia as a barrier to physical activity [11]. It is therefore important to clarify the role of physical activity in the management of type 1 diabetes.

The aim of this literature review was to examine the health benefits of physical activity in type 1 diabetes. Specifically, we analysed physical activity outcomes on fitness, glycaemic control, insulin requirements, vascular risk factors, microvascular complications, cardiovascular disease (CVD), mortality, well-being, beta cell function, osteoporosis and cancer.

Methods

We searched for interventions aimed at increasing physical activity for patients with type 1 diabetes in MEDLINE (OVID). Keywords and free text search were conducted without any limits on study design, study outcome, language or peer reviewed journals. We limited our search to include entries from 1970 to March 2011. For type 1 diabetes, we used both ‘type 1 diabetes mellitus’ and ‘insulin dependent diabetes mellitus’ to increase the sensitivity of the search strategy. Multiple terms reflecting physical activity were used (see the Electronic supplementary material [ESM] Table 1 for further details).

Inclusion criteria were defined mainly based on population and intervention along with a broader outcome category. The population was clinically diagnosed patients with type 1 diabetes. Any intervention that aimed to increase physical activity for more than 7 days, irrespective of intensity, was included in the review. We did not exclude articles based on comparator. Outcomes were broadly defined as physical fitness, glycaemic control and insulin requirements, other vascular risk factors, vascular complications and well-being. HbA1c was used as a primary measure of blood glucose control because it is readily available and validated against hard clinical endpoints. Articles that included other measures of glucose control (fasting blood glucose, continuous glucose monitoring) were also included. All study designs, except case reports and case series with fewer than five patients, were included in the review.

The titles and abstracts of all articles identified were divided and reviewed by four members of the research team (M. Chimen, K. Nirantharakumar, A. Kennedy, P. Narendran). Papers identified as relevant or of uncertain relevance based on the abstracts were further evaluated by M. Chimen and checked by P. Narendran. Any discrepancies were resolved by discussion among all members of the research team.

A narrative synthesis was done for each outcome category indicating the direction of the effect for the outcome. Where results among articles were mostly consistent for a given outcome the effect size has been given as a range. A. Kennedy and R. Andrews used previous reviews on the effect of physical activity on type 2 diabetes to contrast the findings of type 1 diabetes and type 2 diabetes.

Results

We selected 48 articles out of the 1,920 identified in the literature search (ESM Fig. 1). These articles were included in the results for each outcome analysed. Table 1 indicates the quality of physical activity benefit on the selected outcomes, and Fig. 1 outlines these benefits compared with those in type 2 diabetes.
Table 1

Evidence for physical activity benefit in type 1 diabetes and type 2 diabetes

Outcome measure

Physical activity benefita in T1D [ref.]

Physical activity benefita in T2D [ref.]

Physical fitness

2 [19, 26]

1 [64]

4 [13, 20, 21, 23, 24, 25]

Muscle strength

2 [55]

2 [65]

Glycaemic control

3 [31, 38, 66, 67]

1 [3, 28, 29]

4 [68]

Insulin requirement

4 [21, 23]

2 [65]

5 [30]

Lipids

3 [19]

1 [28, 69]

4 [13, 20, 21, 23, 25]

5 [30, 43]

Blood pressure

4 [38]

1 [28]

5 [43]

Endothelial function

4 [23]

3 [45]

8 [46]

Insulin resistance

4 [20, 21, 24]

1 [70]

5 [30]

2 [71]

Microvascular complications

8 [51]

6 [4]

Cardiovascular disease

6 [53]

6 [4]

Mortality

6 [9]

6 [4]

Wellbeing

8 [56]

2 [72]

Beta cell function

No available evidence

3 [59]

Osteoporosis

No available evidence

No available evidence

Cancer

No available evidence

No available evidence

aThe benefit is assigned as number according to strength of evidence [73]:

1. Systematic reviews and meta-analyses

2. Randomised controlled trials with definitive results (confidence intervals that do not overlap the threshold clinically significant effect)

3. Randomised controlled trials with non-definitive results (a point estimate that suggests a clinically significant effect but with confidence intervals overlapping the threshold for this effect)

4. Non-randomised control trial

5. Case series

6. Cohort studies

7. Case–control studies (no instances in this table)

8. Cross-sectional surveys

9. Case reports (no instances in this table)

T1D, type 1 diabetes; T2D, type 2 diabetes

Fig. 1

Health benefits of physical activity in type 1 and type 2 diabetes

Physical fitness

\( \dot{V}{{\text{O}}_{\text{2max}}} \) is a measure of physical fitness and reflects the maximal capacity of the body to transport and utilise oxygen. It is a validated and commonly used measure of fitness that is predictive of mortality [12]. Studies of fitness in patients with type 1 diabetes are small but suggest that, despite similar levels of physical activity, young adults (17–44 years of age) with type 1 diabetes are less fit than matched individuals without diabetes [9, 10, 13, 14]. Abnormalities in cardiac muscle and autonomic nerve function [15], as well as a cardiac metabolism that favours NEFA over glucose as a fuel source [16], may contribute. However, not all studies found lower fitness levels in individuals with type 1 diabetes [17], and data on older patients with type 1 diabetes are not available. Patients with type 2 diabetes similarly have a significantly lower \( \dot{V}{{\text{O}}_{\text{2max}}} \) than healthy age-, BMI- and activity-matched participants without diabetes [18], but no studies to date have directly compared patients with type 1 diabetes and type 2 diabetes.

Supervised physical activity programmes do, however, improve fitness in patients with type 1 diabetes [19, 20, 21] (as well as those with type 2 diabetes [22]). Increases in \( \dot{V}{{\text{O}}_{\text{2max}}} \) of up to 27% have been reported in patients with type 1 diabetes [13, 23, 24, 25, 26], and a similar proportional increase is seen in participants without diabetes [27].

Glycaemic control and insulin requirements

There is clear evidence that physical activity improves glycaemic control in patients with type 2 diabetes [3, 28, 29]. Depending on the intensity and duration, physical activity appears to reduce HbA1c levels in these patients by about 4.2 mmol/mol (0.6%) [3, 22, 29]. Insulin requirements are also reduced.

Studies investigating the effect of physical activity on glycaemic control in type 1 diabetes have so far largely failed to demonstrate a benefit, either on fasting blood glucose or HbA1c (Table 2 and ESM Table 2). Table 2 lists interventional studies of the effect of physical activity on HBA1c where the control group has type 1 diabetes, and ESM Table 2 lists other studies. These studies have predominantly involved adolescents or young adults. They have been both large cross-sectional studies in which physical activity has been estimated through validated questionnaires, as well as smaller randomised controlled and prospective interventional studies. These exercise programmes have generally been of 1–3 months duration, but even a 5-month programme failed to show glycaemic benefit [26]. Studies of resistance exercise programmes in type 1 diabetes have also failed to show a consistent glycaemic benefit [30, 31].
Table 2

Intervention studies evaluating the effect of physical activity on HbA1c in patients with type 1 diabetes

Study

n (Control/T1D)

Mean age ± SD/age range (years)

RCT?

Duration

Type of physical activity

T1D control group

T1D intervention group

HbA1c before (mmol/mol)

HbA1c after (mmol/mol)

HbA1c before (mmol/mol)

HbA1c after (mmol/mol)

(%)

(%)

(%)

(%)

No HbA1c effect

Yki-Jarvinen et al. [21]

6/7

NA

No

6 weeks

Supervised aerobic physical activity

70 ± 5

70 ± 5

70 ± 5

70 ± 5

8.6 ± 0.4

8.6 ± 0.4

8.6 ± 0.4

8.6 ± 0.4

Landt et al. [24]

6/9

14–16

No

12 weeks

Supervised aerobic physical activity

108 ± 11

108 ± 11

108 ± 11

108 ± 11

12 ± 1

12 ± 1

12 ± 1

12 ± 1

Wallberg-Henriksson et al. [26]

7/6

25–45

No

5 months

Non-supervised aerobic physical activity

92 ± 7

90 ± 7

90 ± 7

91 ± 7

10.6 ± 0.6

10.4 ± 0.6

10.4 ± 0.6

10.5 ± 0.6

Huttunen et al. [33]

16/16

8.2–16.9

No

3 months

Supervised aerobic physical activity

79 ± 23

83 ± 24

84 ± 25

91 ± 28

9.4 ± 2.1

9.7 ± 2.2

9.8 ± 2.3

10.5 ± 2.5

Laaksonen et al. [19]

28/28

32.5 ± 5.7

Yes

12–16 weeks

Supervised aerobic physical activity

66 ± 12

66 ± 11

67 ± 14

69 ± 18

8.2 ± 1.1

8.2 ± 1.0

8.3 ± 1.3

8.5 ± 1.6

Fuchsjager-Mayrl et al. [23]

8/18

42 ± 10

No

4 months

Supervised aerobic physical activity

57 ± 6

55 ± 2

56 ± 2

58 ± 4

7.4 ± 0.4

7.2 ± 0.2

7.3 ± 0.2

7.5 ± 0.3

HbA1c improvement

Dahl-Jorgensen et al. [68]

8/14

5–11

No

5 months

Supervised aerobic physical activity

123 ± 21

117 ± 18

142 ± 49

127 ± 21

13.4 ± 1.9

12.9 ± 1.6

15.1 ± 2.2

13.8 ± 1.9

Campaigne et al. [66]

9/10

9 ± 0.47

Yes

12 weeks

Supervised vigorous physical activity

128 ± 8

122 ± 6

113 ± 7

100 ± 5

13.9 ± 0.61

13.3 ± 0.54

12.5 ± 0.65

11.3 ± 0.5

Durak et al. [31]

8/8 (crossover)

31 ± 3.5

Yes

10 weeks

Supervised heavy resistance training

52 ± 15

52 ± 15

52 ± 15

40 ± 10

6.9 ± 1.4

6.9 ± 1.4

6.9 ± 1.4

5.8 ± 0.9

Perry et al. [67]

30/31

20–69

Yes

6 months

Non-supervised aerobic physical activity

72 ± 21

73 ± 25

74 ± 28

70 ± 23

8.7 ± 2.0

8.8 ± 2.3

8.9 ± 2.6

8.6 ± 2.1

Salem et al. [38]

48/moderate 75/intensive 73

14.5 ± 2.4

Yes

6 months

Supervised aerobic and resistance physical activity

67 ± 23

74 ± 15

Moderate: 74 ± 15

Moderate: 65 ± 12

8.9 ± 1.4

8.1 ± 1.1

8.3 ± 2.1

8.9 ± 1.4

Intensive 74 ± 17

Intensive 62 ± 11

8.9 ± 1.6

7.8 ± 1.0

All studies quoted have included patients with type 1 diabetes in both the intervention and control groups. The studies are listed in chronological order according to whether or not physical activity improved HbA1c.

NA, not available; RCT, randomised controlled trial; T1D, type 1 diabetes

A number of factors may contribute to the lack of detectable benefit on glycaemic control. Energy consumption appears to be increased around the time of physical activity in individuals with type 1 diabetes, either as a source of fuel or to manage hypoglycaemia, and this may counteract any glucose-lowering effect of physical activity [27]. The majority of reported studies failed to incorporate the exercise schedule into an overall programme of diet and lifestyle intervention. Whilst this was not the aim of these studies, such an approach may help improve long-term glycaemic control. It is also intriguing that some of the studies reporting a glycaemic benefit have involved vigorous exercise, and these are in contrast to the majority of other studies, which did not report a benefit and employed a moderate exercise programme (Table 2 and ESM Table 2). Parallel studies on type 2 diabetes suggest that greater activity intensity is associated with greater reductions in HbA1c [32].

Studies on type 1 diabetes that have estimated glycaemic control through fasting blood glucose have also failed to show a consistent benefit [21, 31, 33, 34]. Predictably, however, these studies demonstrated that blood glucose decreases (without hypoglycaemia) around the time of exercise [35, 36], as it does in healthy individuals [37]. The lack of glycaemic benefit as assessed by HbA1c may result from rebound hyperglycaemia immediately following exercise, and better control of this may show a benefit.

Studies on type 1 diabetes consistently demonstrate that physical activity is associated with reduced insulin requirements. This reduction varies from 6% [21] to over 15% [23, 30]. Whilst some of this may have been required to manage hypoglycaemia, it is possible that that these reductions masked any glycaemic improvement as measured by HbA1c. In support of this notion, insulin doses were reduced in two of the six studies (33%) [21, 23] in Table 2 that showed no HbA1c improvement, as opposed to one of the five studies (20%) that did [38].

It therefore remains to be elucidated whether vigorous activity, incorporation of a dietary programme and/or appropriate insulin therapy can demonstrate that physical activity provides a glycaemic benefit in type 1 diabetes. It is also not clear whether physical activity will be of benefit in age groups outside those that include children and young adults.

Most studies did not record the frequency of hypoglycaemic events. Of the few that did, two observed no increase in the frequency of hypoglycaemia with exercise [24, 38], whilst one showed a minimal increase (that could easily have been addressed through insulin dose adjustment) [21]. Hypoglycaemia is, however, a perceived barrier to exercise in patients with type 1 diabetes [11] and therefore requires further study. It is clear that exercise-induced hypoglycaemia can occur in a laboratory environment without glucose supplementation [39] and that it can also occur in people without diabetes [40]. However, in cross-sectional studies [41], as well as all studies outlined in this review, it appears that hypoglycaemia is not a significant factor, and is a concern that can be managed using simple approaches to insulin and carbohydrate adjustment.

In summary, the available studies demonstrate that, in a trial setting, physical activity can be conducted safely and with minimal hypoglycaemia, and that regular moderate intensity exercise of the kind currently advocated by the diabetes associations can be adhered to by patients with type 1 diabetes over a medium-term period.

Vascular risk factors other than glucose

Patients with type 1 diabetes are at risk of high blood pressure, triacylglycerols and LDL-cholesterol, and of low levels of HDL-cholesterol. These factors are associated with increased risk of vascular disease [42].

Most, but not all, studies of physical activity in patients with type 1 diabetes demonstrate a beneficial effect on lipid levels [13, 19, 20, 21, 23, 25, 43]. These studies involved exercise programmes lasting up to 4 months, and showed benefits similar to those demonstrated in individuals without diabetes, increasing HDL-cholesterol by 8–30%, while decreasing LDL-cholesterol by 8–14% and triacylglycerols by 13–15%. More specifically, there appears to be a reduction in apolipoprotein B, which is pro-atherogenic and is associated with premature mortality in type 1 diabetes [44]. Physical activity also increases levels of the anti-atherogenic apolipoprotein A-I [19]. There is general agreement amongst studies that these benefits are independent of changes in glycaemic control and weight and that they are most pronounced in those with an adverse lipid profile.

Evidence for the benefits of physical activity on blood pressure in type 1 diabetes is limited. Of four prospective intervention studies, two failed to detect a benefit with respect to systolic or diastolic blood pressure [23, 25], whilst two did (2–3%) [38, 43]. All four studies examined young adult patients with type 1 diabetes and involved very similar physical activity programmes. Three of the studies had relatively small study cohorts (26, 14 and 20 participants, respectively [23, 25, 43]), whereas one, which showed a diastolic blood pressure benefit, recruited 196 [38].

In contrast with these results, in type 2 diabetes there are now good data showing evidence for physical activity improving blood pressure and lipids [28]. This discrepancy may be because patients with type 1 diabetes are younger and more likely to be normotensive and less likely to have dyslipidaemia, making it more difficult to demonstrate a benefit.

Impaired endothelial function is associated with vascular complications and can be reversed by physical activity both in individuals without diabetes and in those with type 2 diabetes [45]. Patients with type 1 diabetes, particularly those with microalbuminurea, display clear evidence of endothelial dysfunction [10]. Vascular function does improve following physical activity in type 1 diabetes, but not to the same extent as it does in individuals without diabetes [23, 46]. The improvement is evident across a number of vascular beds, not just the one supplying the exercising muscles, suggesting a systemic benefit of exercise. These benefits only persist for the period of physical activity and cease once regular activity is stopped. Nevertheless, exercise should be practised cautiously in patients with microalbuminurea as it increases with exercise intensity in adolescents with type 1 diabetes [47].

Patients with type 1 diabetes are more insulin resistant than matched non-diabetic individuals [10, 21]. Both resistance and endurance exercises improve insulin sensitivity in type 2 diabetes [48] and type 1 diabetes by up to 23% [20, 21, 24, 30].

Insulin resistance is independently associated with the risk of developing both macro- and microvascular complications in type 1 diabetes [49]. The beneficial effects of physical activity on insulin resistance, as well as on lipid levels and endothelial function, suggest that physical activity should reduce vascular complications in type 1 diabetes. What then is the evidence for this?

Microvascular complications

The presence of diabetic complications is associated with reduced physical activity in type 1 diabetes [50]. However, causality has not been demonstrated, and this association could be explained by the presence of complications impairing the ability to undertake physical activity, rather than physical activity decreasing the complications of diabetes. The best evidence for the protective effect of physical activity in type 1 diabetes currently comes from the Pittsburgh IDDM Morbidity and Mortality Study [51]. This is a longitudinal study of 628 largely white Europid adults with a long duration of diabetes (66% participants with over 20 years’ duration). These adults were asked to estimate the physical activity they undertook during their teenage years. Their level of activity was found to be inversely associated with the risk of nephropathy and neuropathy. The association was found in men but not women, and was not seen with retinopathy. Although this study controlled for a number of important factors, the subjective estimation of physical activity and the lack of reproducibility with retinopathy weakens the findings.

There are limited data for a microvascular benefit of physical activity in type 2 diabetes. Studies on type 2 diabetes have shown increased urinary protein excretion immediately after physical activity [52], but there is no evidence that physical activity influences the progression of nephropathy in humans.

CVD and mortality

CVD is increased in both type 1 diabetes and type 2 diabetes and is the most common cause of death [42]. Whilst intervention studies have yet to demonstrate that physical activity reduces CVD in type 2 diabetes, there are clear associations in this disease between low levels of physical activity and CVD [28].

With respect to type 1 diabetes, the Pittsburgh IDDM Morbidity and Mortality study demonstrated that at 25 years’ duration of diabetes, men who had participated in team sports during high school were three times less likely to report macrovascular disease and had mortality rates three times lower than those who did not [53]. This pattern was not seen in women, but their participation in team sports was lower (24% reported participation compared with 39% in men), possibly explaining the failure to detect statistical significance. The study also demonstrated that those patients who had participated in team sports during their youth tended to maintain higher levels of physical activity throughout adulthood.

Further follow-up of these adult patients showed that the level of physical activity in adulthood (measured using a validated questionnaire) predicted mortality at 6 years [9]. Sedentary men were three times more likely to die than active men, and a similar (but, again, non-significant) effect was seen in women. Unfortunately, data on the cause of death and the age groups benefitting from mortality reduction were not available. However, confounders were adjusted for and a large number of patients (548) was studied. This is currently the seminal study on this topic.

Well-being

The incidence of depression is three times higher in type 1 diabetes compared with the general population [54]. Physical activity is associated with significantly greater satisfaction with life and well-being [55]. These benefits have so far only been demonstrated in adults and not in children [56].

Depression is also common in patients with type 2 diabetes. Increased physical fitness improves health-related quality of life scores in these patients (Medical Outcomes Study 36-item Short-Form Health Survey [SF-36] physical component) [4], but to date no studies have looked at the effect of exercise on well-being as measured by diabetes-specific questionnaires.

Beta cell function, osteoporosis and cancer

The loss of beta cells that results in type 1 diabetes is a gradual process and significant beta cell function is present at the time of diagnosis [57]. The preservation of these cells improves glucose control, reduces long-term complications and more than halves the rate of hypoglycaemia [58]. Although the mechanism is unclear, physical activity appears to preserve beta cell function in animal models, patients with type 2 diabetes and healthy individuals [59]. This benefit of physical activity has not been examined in patients with type 1 diabetes.

Physical activity imparts a global anti-inflammatory effect by acting on the number and function of immune cells [60]. Whilst this is clearly of relevance to an immune-mediated disease such as type 1 diabetes, a direct effect of physical activity on (auto)immunity to the pancreatic beta cell has yet to be demonstrated.

Reduced bone mineral density (BMD), osteoporosis and increased risk of fracture (at any site) are recognised complications of type 1 diabetes [61]. In type 2 diabetes, fracture risk appears to be increased in the presence of normal, or even increased, BMD [61]. The increase in fracture risk in type 2 diabetes may be related to an increased risk of falls (due to neuropathy) or alteration of bone architecture. To our knowledge, there are no studies on the effect of physical activity on BMD or fracture risk in either type 1 diabetes or type 2 diabetes.

Cancer is a recognised complication of type 2 diabetes and obesity [62]. The data for type 1 diabetes is less clear [63]. Physical activity appears to protect the general population from cancer and improve outcomes in those who do develop cancer (surgical outcome, side effects of chemotherapy, subsequent prevention of recurrence). Again, this has not been examined in either type 1 or type 2 diabetes.

Conclusion

Physical activity improves physical fitness and strength, reduces cardiovascular risk factors and improves well-being in type 1 diabetes (Fig. 1). It also significantly reduces insulin requirements. Whilst physical activity has yet to demonstrably improve glycaemic control as measured by HbA1c, there are a number of potential explanations that require further investigation.

The few randomised control trials reported for type 1 diabetes to date have been small, of short duration and have not controlled for confounding factors such as diet or adjustment of insulin dosage. They do not provide guidance on the intensity, duration or type (aerobic/resistance) of physical activity that will provide the greatest benefit. There is an urgent need for large randomised controlled trials to examine these issues. There are also a number of important outcomes that have not been examined in type 1 diabetes.

The current evidence is, however, sufficient for clinicians to advocate physical activity as part of the management of patients with type 1 diabetes. The current evidence also suggests that physical activity can be undertaken safely and with defined benefits at the levels currently recommended by the major diabetes associations.

Notes

Duality of interest

The authors declare that there is no duality of interest associated with this manuscript.

Contribution statement

The authors contributed in the following ways: conception and design (MC, PN, KN), analysis and interpretation of data (MC, PN, KN, TTP, AK, RA), drafting the article (MC, PN) or revising it critically for important intellectual content (MC, PN, KN, AK, TTP, RA). All authors gave approval for the final version to be published.

Supplementary material

125_2011_2403_MOESM1_ESM.pdf (14 kb)
ESM Table 1 (PDF 14.4 kb)
125_2011_2403_MOESM2_ESM.pdf (125 kb)
ESM Table 2 (PDF 125 kb)
125_2011_2403_MOESM3_ESM.pdf (37 kb)
ESM Fig. 1 (PDF 36.7 kb)

References

  1. 1.
    Department of Health (2004) The benefits of physical activity for adult health. In: At least five a week. Evidence on the impact of physical activity and its relationship to health. A report from the Chief Medical Officer. Department of Health, London, pp 38–64Google Scholar
  2. 2.
    Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403PubMedCrossRefGoogle Scholar
  3. 3.
    Thomas D, Elliott EJ, Naughton GA. Exercise for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. no.: CD002968. doi: 10.1002/14651858.CD002968.pub2
  4. 4.
    Colberg SR, Sigal RJ, Fernhall B et al (2010) Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 33:e147–e167PubMedCrossRefGoogle Scholar
  5. 5.
    Ryden L, Standl E, Bartnik M et al (2007) Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Hear J 28:88–136CrossRefGoogle Scholar
  6. 6.
    Church TS, Blair SN, Cocreham S et al (2010) Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 304:2253–2262PubMedCrossRefGoogle Scholar
  7. 7.
    American Diabetes Association (2002) Diabetes mellitus and exercise. Diabetes Care 25(Suppl 1):S64–S68Google Scholar
  8. 8.
    Robertson K, Adolfsson P, Scheiner G, Hanas R, Riddell MC (2009) Exercise in children and adolescents with diabetes. Pediatr Diabetes 10(Suppl 12):154–168PubMedCrossRefGoogle Scholar
  9. 9.
    Moy CS, Songer TJ, LaPorte RE et al (1993) Insulin-dependent diabetes mellitus, physical activity, and death. Am J Epidemiol 137:74–81PubMedGoogle Scholar
  10. 10.
    Nadeau KJ, Regensteiner JG, Bauer TA et al (2010) Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab 95:513–521PubMedCrossRefGoogle Scholar
  11. 11.
    Brazeau AS, Rabasa-Lhoret R, Strychar I, Mircescu H (2008) Barriers to physical activity among patients with type 1 diabetes. Diabetes Care 31:2108–2109PubMedCrossRefGoogle Scholar
  12. 12.
    Regensteiner JG (2004) Type 2 diabetes mellitus and cardiovascular exercise performance. Rev Endocr Metab Disord 5:269–276PubMedCrossRefGoogle Scholar
  13. 13.
    Mosher PE, Nash MS, Perry AC, LaPerriere AR, Goldberg RB (1998) Aerobic circuit exercise training: effect on adolescents with well-controlled insulin-dependent diabetes mellitus. Arch Phys Med Rehabil 79:652–657PubMedCrossRefGoogle Scholar
  14. 14.
    Niranjan V, McBrayer DG, Ramirez LC, Raskin P, Hsia CC (1997) Glycemic control and cardiopulmonary function in patients with insulin-dependent diabetes mellitus. Am J Med 103:504–513PubMedCrossRefGoogle Scholar
  15. 15.
    Piya MK, Shivu GN, Tahrani A et al (2011) Abnormal left ventricular torsion and cardiac autonomic dysfunction in subjects with type 1 diabetes mellitus. Metabolism 60:1115–1121PubMedCrossRefGoogle Scholar
  16. 16.
    Herrero P, Peterson LR, McGill JB et al (2006) Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus. J Am Coll Cardiol 47:598–604PubMedCrossRefGoogle Scholar
  17. 17.
    Veves A, Saouaf R, Donaghue VM et al (1997) Aerobic exercise capacity remains normal despite impaired endothelial function in the micro- and macrocirculation of physically active IDDM patients. Diabetes 46:1846–1852PubMedCrossRefGoogle Scholar
  18. 18.
    Regensteiner JG, Sippel J, McFarling ET, Wolfel EE, Hiatt WR (1995) Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Med Sci Sports Exerc 27:661–667PubMedGoogle Scholar
  19. 19.
    Laaksonen DE, Atalay M, Niskanen LK et al (2000) Aerobic exercise and the lipid profile in type 1 diabetic men: a randomized controlled trial. Med Sci Sports Exerc 32:1541–1548PubMedCrossRefGoogle Scholar
  20. 20.
    Wallberg-Henriksson H, Gunnarsson R, Henriksson J et al (1982) Increased peripheral insulin sensitivity and muscle mitochondrial enzymes but unchanged blood glucose control in type I diabetics after physical training. Diabetes 31:1044–1050PubMedCrossRefGoogle Scholar
  21. 21.
    Yki-Jarvinen H, DeFronzo RA, Koivisto VA (1984) Normalization of insulin sensitivity in type I diabetic subjects by physical training during insulin pump therapy. Diabetes Care 7:520–527PubMedCrossRefGoogle Scholar
  22. 22.
    Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S (2010) Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetol 47:15–22PubMedCrossRefGoogle Scholar
  23. 23.
    Fuchsjager-Mayrl G, Pleiner J, Wiesinger GF et al (2002) Exercise training improves vascular endothelial function in patients with type 1 diabetes. Diabetes Care 25:1795–1801PubMedCrossRefGoogle Scholar
  24. 24.
    Landt KW, Campaigne BN, James FW, Sperling MA (1985) Effects of exercise training on insulin sensitivity in adolescents with type I diabetes. Diabetes Care 8:461–465PubMedCrossRefGoogle Scholar
  25. 25.
    Rigla M, Sanchez-Quesada JL, Ordonez-Llanos J et al (2000) Effect of physical exercise on lipoprotein(a) and low-density lipoprotein modifications in type 1 and type 2 diabetic patients. Metabolism 49:640–647PubMedCrossRefGoogle Scholar
  26. 26.
    Wallberg-Henriksson H, Gunnarsson R, Rossner S, Wahren J (1986) Long-term physical training in female type 1 (insulin-dependent) diabetic patients: absence of significant effect on glycaemic control and lipoprotein levels. Diabetologia 29:53–57PubMedCrossRefGoogle Scholar
  27. 27.
    Zinman B, Zuniga-Guajardo S, Kelly D (1984) Comparison of the acute and long-term effects of exercise on glucose control in type I diabetes. Diabetes Care 7:515–519PubMedCrossRefGoogle Scholar
  28. 28.
    Chudyk A, Petrella RJ (2011) Effects of exercise on cardiovascular risk factors in type 2 diabetes: a meta-analysis. Diabetes Care 34:1228–1237PubMedCrossRefGoogle Scholar
  29. 29.
    Umpierre D, Ribeiro PA, Kramer CK et al (2011) Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. JAMA 305:1790–1799PubMedCrossRefGoogle Scholar
  30. 30.
    Ramalho AC, de Lourdes LM, Nunes F et al (2006) The effect of resistance versus aerobic training on metabolic control in patients with type-1 diabetes mellitus. Diabetes Res Clin Pract 72:271–276PubMedCrossRefGoogle Scholar
  31. 31.
    Durak EP, Jovanovic-Peterson L, Peterson CM (1990) Randomized crossover study of effect of resistance training on glycemic control, muscular strength, and cholesterol in type I diabetic men. Diabetes Care 13:1039–1043PubMedCrossRefGoogle Scholar
  32. 32.
    Bweir S, Al-Jarrah M, Almalty AM et al (2009) Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes. Diabetol Metab Syndr 1:27PubMedCrossRefGoogle Scholar
  33. 33.
    Huttunen NP, Lankela SL, Knip M et al (1989) Effect of once-a-week training program on physical fitness and metabolic control in children with IDDM. Diabetes Care 12:737–740PubMedCrossRefGoogle Scholar
  34. 34.
    Haider DG, Pleiner J, Francesconi M, Wiesinger GF, Muller M, Wolzt M (2006) Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes. J Clin Endocrinol Metab 91:4702–4704PubMedCrossRefGoogle Scholar
  35. 35.
    Baevre H, Sovik O, Wisnes A, Heiervang E (1985) Metabolic responses to physical training in young insulin-dependent diabetics. Scand J Clin Lab Invest 45:109–114PubMedCrossRefGoogle Scholar
  36. 36.
    Sideraviciute S, Gailiuniene A, Visagurskiene K, Vizbaraite D (2006) The effect of long-term swimming program on glycemia control in 14–19-year aged healthy girls and girls with type 1 diabetes mellitus. Medicina (Kaunas) 42:513–518Google Scholar
  37. 37.
    Mikus CR, Oberlin DJ, Libla JL, Taylor AM, Booth FW, Thyfault JP (2011) Lowering physical activity impairs glycemic control in healthy volunteers. Med Sci Sports Exerc. doi: 10.1249/MSS.0b013e31822ac0c0
  38. 38.
    Salem MA, Aboelasrar MA, Elbarbary NS, Elhilaly RA, Refaat YM (2010) Is exercise a therapeutic tool for improvement of cardiovascular risk factors in adolescents with type 1 diabetes mellitus? A randomised controlled trial. Diabetol Metab Syndr 2:47PubMedCrossRefGoogle Scholar
  39. 39.
    Tansey MJ, Tsalikian E, Beck RW et al (2006) The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes. Diabetes Care 29:20–25PubMedCrossRefGoogle Scholar
  40. 40.
    Felig P, Cherif A, Minagawa A, Wahren J (1982) Hypoglycemia during prolonged exercise in normal men. N Engl J Med 306:895–900PubMedCrossRefGoogle Scholar
  41. 41.
    Herbst A, Bachran R, Kapellen T, Holl RW (2006) Effects of regular physical activity on control of glycemia in pediatric patients with type 1 diabetes mellitus. Arch Pediatr Adolesc Med 160:573–577PubMedCrossRefGoogle Scholar
  42. 42.
    Soedamah-Muthu SS, Fuller JH, Mulnier HE, Raleigh VS, Lawrenson RA, Colhoun HM (2006) All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999. Diabetologia 49:660–666PubMedCrossRefGoogle Scholar
  43. 43.
    Lehmann R, Kaplan V, Bingisser R, Bloch KE, Spinas GA (1997) Impact of physical activity on cardiovascular risk factors in IDDM. Diabetes Care 20:1603–1611PubMedCrossRefGoogle Scholar
  44. 44.
    Stettler C, Suter Y, Allemann S, Zwahlen M, Christ ER, Diem P (2006) Apolipoprotein B as a long-term predictor of mortality in type 1 diabetes mellitus: a 15-year follow up. J Intern Med 260:272–280PubMedCrossRefGoogle Scholar
  45. 45.
    Sixt S, Beer S, Bluher M et al (2010) Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease. Eur Hear J 31:112–119CrossRefGoogle Scholar
  46. 46.
    Mason NJ, Jenkins AJ, Best JD, Rowley KG (2006) Exercise frequency and arterial compliance in non-diabetic and type 1 diabetic individuals. Eur J Cardiovasc Prev Rehabil 13:598–603PubMedCrossRefGoogle Scholar
  47. 47.
    Kornhauser C, Malacara JM, Macias-Cervantes MH, Rivera-Cisneros AE (2011) Effect of exercise intensity on albuminuria in adolescents with type 1 diabetes mellitus. Diabet Med doi: 10.1111/j.1464-5491.2011.03380.x
  48. 48.
    Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley HD, Frohlich JJ (2003) Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 26:2977–2982PubMedCrossRefGoogle Scholar
  49. 49.
    Chaturvedi N, Sjoelie AK, Porta M et al (2001) Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes. Diabetes Care 24:284–289PubMedCrossRefGoogle Scholar
  50. 50.
    Waden J, Forsblom C, Thorn LM et al (2008) Physical activity and diabetes complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study. Diabetes Care 31:230–232PubMedCrossRefGoogle Scholar
  51. 51.
    Kriska AM, LaPorte RE, Patrick SL, Kuller LH, Orchard TJ (1991) The association of physical activity and diabetic complications in individuals with insulin-dependent diabetes mellitus: the Epidemiology of Diabetes Complications Study—VII. J Clin Epidemiol 44:1207–1214PubMedCrossRefGoogle Scholar
  52. 52.
    Koh KH, Dayanath B, Doery JC et al (2011) The effect of exercise on urine albuminuria excretion in diabetic subjects. Nephrology (Carlton) 16:704–709. doi: 10.1111/j.1440-1797.2011.01508.x CrossRefGoogle Scholar
  53. 53.
    LaPorte RE, Dorman JS, Tajima N et al (1986) Pittsburgh Insulin-Dependent Diabetes Mellitus Morbidity and Mortality Study: physical activity and diabetic complications. Pediatrics 78:1027–1033PubMedGoogle Scholar
  54. 54.
    Kokkonen J, Lautala P, Salmela P (1997) The state of young adults with juvenile onset diabetes. Int J Circumpolar Health 56:76–85PubMedGoogle Scholar
  55. 55.
    Zoppini G, Carlini M, Muggeo M (2003) Self-reported exercise and quality of life in young type 1 diabetic subjects. Diabetes Nutr Metab 16:77–80PubMedGoogle Scholar
  56. 56.
    Edmunds S, Roche D, Stratton G, Wallymahmed K, Glenn SM (2007) Physical activity and psychological well-being in children with type 1 diabetes. Psychol Health Med 12:353–363PubMedCrossRefGoogle Scholar
  57. 57.
    Sherry NA, Tsai EB, Herold KC (2005) Natural history of beta-cell function in type 1 diabetes. Diabetes 54(Suppl 2):S32–S39PubMedCrossRefGoogle Scholar
  58. 58.
    Steffes MW, Sibley S, Jackson M, Thomas W (2003) Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 26:832–836PubMedCrossRefGoogle Scholar
  59. 59.
    Slentz CA, Tanner CJ, Bateman LA et al (2009) Effects of exercise training intensity on pancreatic beta-cell function. Diabetes Care 32:1807–1811PubMedCrossRefGoogle Scholar
  60. 60.
    Walsh NP, Gleeson M, Shephard RJ et al (2011) Position statement. Part one: immune function and exercise. Exerc Immunol Rev 17:6–63PubMedGoogle Scholar
  61. 61.
    Janghorbani M, van Dam RM, Willett WC, Hu FB (2007) Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166:495–505PubMedCrossRefGoogle Scholar
  62. 62.
    Simon D, Balkau B (2010) Diabetes mellitus, hyperglycaemia and cancer. Diabetes Metab 36:182–191PubMedCrossRefGoogle Scholar
  63. 63.
    Swerdlow AJ, Laing SP, Qiao Z et al (2005) Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study. Br J Cancer 92:2070–2075PubMedCrossRefGoogle Scholar
  64. 64.
    Boule NG, Kenny GP, Haddad E, Wells GA, Sigal RJ (2003) Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in type 2 diabetes mellitus. Diabetologia 46:1071–1081PubMedCrossRefGoogle Scholar
  65. 65.
    Castaneda C, Layne JE, Munoz-Orians L et al (2002) A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 25:2335–2341PubMedCrossRefGoogle Scholar
  66. 66.
    Campaigne BN, Gilliam TB, Spencer ML, Lampman RM, Schork MA (1984) Effects of a physical activity program on metabolic control and cardiovascular fitness in children with insulin-dependent diabetes mellitus. Diabetes Care 7:57–62PubMedCrossRefGoogle Scholar
  67. 67.
    Perry TL, Mann JI, Lewis-Barned NJ, Duncan AW, Waldron MA, Thompson C (1997) Lifestyle intervention in people with insulin-dependent diabetes mellitus (IDDM). Eur J Clin Nutr 51:757–763PubMedCrossRefGoogle Scholar
  68. 68.
    Dahl-Jorgensen K, Meen HD, Hanssen KF, Aagenaes O (1980) The effect of exercise on diabetic control and hemoglobin A1 (HbA1) in children. Acta Paediatr Scand 283:53–56CrossRefGoogle Scholar
  69. 69.
    Kelley GA, Kelley KS (2007) Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials. Public Health 121:643–655PubMedCrossRefGoogle Scholar
  70. 70.
    Ishii T, Yamakita T, Sato T, Tanaka S, Fujii S (1998) Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake. Diabetes Care 21:1353–1355PubMedCrossRefGoogle Scholar
  71. 71.
    Winnick JJ, Sherman WM, Habash DL et al (2008) Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab 93:771–778PubMedCrossRefGoogle Scholar
  72. 72.
    Williamson DA, Rejeski J, Lang W, van Dorsten B, Fabricatore AN, Toledo K (2009) Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Intern Med 169:163–171PubMedCrossRefGoogle Scholar
  73. 73.
    Greenhalgh T (1997) How to read a paper. Getting your bearings (deciding what the paper is about). BMJ 315:243–246PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • M. Chimen
    • 1
  • A. Kennedy
    • 1
    • 2
  • K. Nirantharakumar
    • 3
  • T. T. Pang
    • 1
    • 4
  • R. Andrews
    • 5
  • P. Narendran
    • 1
    • 2
    Email author
  1. 1.Institute of Biomedical Research, School of Clinical and Experimental MedicineUniversity of BirminghamBirminghamUK
  2. 2.Department of DiabetesUniversity Hospital BirminghamBirminghamUK
  3. 3.School of Health and Population SciencesUniversity of BirminghamBirminghamUK
  4. 4.Diabetes and Endocrine Centre, Russells Hall Hospital, Dudley Group of HospitalsNHS Foundation TrustDudleyUK
  5. 5.School of Clinical SciencesUniversity of BristolBristolUK

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