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Table 2 Crude incidence rates and adjusted HRs for all-cause mortality according to category of baseline glycated haemoglobin

From: No evidence of an increased mortality risk associated with low levels of glycated haemoglobin in a non-diabetic UK population

  Glycated haemoglobin (%) p value for trend
<4.5 4.5 to <5.0 5.0 to <5.5a 5.5 to <6.0 6.0 to <6.5 ≥6.5
Number of individuals 943 2,799 6,515 5,236 1,355 348  
All-cause death (n) 64 201 629 696 273 90  
 Rate (/1,000 py) 5.7 (4.5–7.3) 6.2 (5.4–7.1) 8.7 (8.0–9.4) 12.1 (11.3–13.1) 18.5 (16.4–20.8) 24.6 (20.0–30.2)  
 HR (95% CI), age- and sex-adjusted 0.99 (0.77–1.27) 0.99 (0.86–1.13) 1.00 (0.92–1.08) 1.12 (1.04–1.21) 1.41 (1.25–1.59) 1.70 (1.37–2.10) <0.0001
 HR (95% CI), multivariate adjustedb 0.94 (0.72–1.22) 0.99 (0.86–1.13) 1.00 (0.92–1.08) 1.10 (1.02–1.19) 1.29 (1.14–1.46) 1.45 (1.16–1.80) <0.0001
  1. aReference category
  2. bAdjusted for age, sex, systolic blood pressure, total cholesterol, smoking status, waist-to-hip-ratio, alcohol consumption and physical activity; numbers of deaths/total were 1,893/16,767 because of missing values of covariates
  3. py, person-years