, Volume 48, Issue 7, pp 1418–1418 | Cite as

Coffee, diabetes and insulin sensitivity

Letter Comment

To the Editor: Two recently published studies have suggested that habitual consumption of coffee reduces the risk of developing type 2 diabetes [1, 2]. The mechanisms involved are unknown but are likely to relate to the effects of caffeine on insulin action. Although acute studies show that caffeine loading is associated with a reduction in insulin sensitivity, this effect appears to be lost following sustained consumption [3].

In type 1 diabetes, caffeine has been reported to enhance the symptomatic and hormonal responses to hypoglycaemia [4], but its effects on insulin sensitivity are unknown.

In 1999 a 33-year-old man, a long-term consumer of coffee, was converted to continuous subcutaneous insulin infusion as part of a clinical trial. He developed type 1 diabetes at the age of 3, but apart from diabetic retinopathy, has remained well with HbA1c levels of between 7 and 8%. Recently, on two occasions separated by 2 weeks, he consumed his usual breakfast (a bowl of cereal) but kept the background insulin infusion rate unaltered. At 10.30 h on the first occasion, he drank a cup of instant coffee with a dash of semi-skimmed milk (no sugar). Subsequently, identical cups of coffee were consumed hourly, the last one taken at 16.00 hours. Two weeks later he drank equivalent volumes of diluted Ribena Light at the same time, but he drank no coffee. Fingerstick glucose levels were checked before each drink (Fig. 1). Here, excessive coffee ingestion was associated with marked hyperglycaemia. Although tolerance is well recognised, not all of the physiological responses to sustained caffeine use are attenuated with sustained consumption [5, 6]. Excess ingestion of coffee may be a contributing factor in patients with sub-optimal glycaemic control. Like many pleasurable things in life, a little of what you fancy does you good; too much, and trouble can ensue.
Fig. 1

Fingerstick glucose levels before and after ingestion of hourly cups of coffee (light bars) or diluted sugar-free Ribena Light (dark bars), which followed a normal breakfast. The 16.00-hour blood test with caffeine was associated with ketonuria. Fasting basal rates were unchanged


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    Yamaji T, Mizoue T, Tabata S et al (2004) Coffee consumption and glucose tolerance status in middle-aged Japanese men. Diabetologia 47:2145–2151CrossRefPubMedGoogle Scholar
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    Van Dam RM, Dekker JM, Nijpels G et al (2004) Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn study. Diabetologia 47:2152–2159CrossRefPubMedGoogle Scholar
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    Arnlov J, Vessby B, Riserus U (2004) Coffee consumption and insulin sensitivity. JAMA 291:1199–1201CrossRefPubMedGoogle Scholar
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    Watson J, Jenkins E, Hamilton P, Kerr D (2000) Influence of caffeine on the frequency of hypoglycaemia among free-living patients with type-1 diabetes. Diabetes Care 23:455–459PubMedGoogle Scholar
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    Watson J, Deary I, Kerr D (2002) Central and peripheral effects of sustained caffeine use: tolerance is incomplete. Br J Clin Pharmacol 54:400–406CrossRefPubMedGoogle Scholar
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    Watson J, Sherwin R, Deary I, Scott L, Kerr D (2003) Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin Sci 104:447–454CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Bournemouth Diabetes and Endocrine CentreRoyal Bournemouth HospitalBournemouthUK

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