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Table 2 Absolute and relative (%) changes in glucose metabolism from baseline to 12 weeks

From: Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity

  Control (n=19) CLA (n=19) t10c12 CLA (n=19)
BMI (kg/m2)a −0.05±0.5 (0.1%) −0.15±0.6 (0.5%) −0.27±0.4 (0.9%)
Plasma proinsulin (pmol/l) −0.86±4.7 (−5%) 1.90±9.4 (13%) 2.84±7.3 (19%)c
Plasma insulin (pmol/l)a 5.5±23.3 (8%) 4.8±19.2 (7%) 14.4±23.7 (21%)
Proinsulin : insulin ratio −0.06±0.09 (−5%) −0.02±0.10 (−2%) 0.02±0.11 (2%)b
Plasma C-peptide (pmol/l) −96±181 (−10%) 47±127 (6% ) 88±122 (10%)d
Plasma glucose (mmol/l)a −0.14±0.24 (−2%) 0.01±0.30 (0%) 0.21±0.33 (4%)d
Plasma adiponectin (µg/ml) 0.49±1.5 (14%) 0.26±1.5 (3%) 0.01±2.5 (0.1%)
Insulin sensitivity (M, mg·kg−1·min−1)a 0.44±1.02 (12%) −0.05±0.97 (−1%) −0.55±0.95 (−15%)c
  1. Data are means ± SD. a These values were previously reported [6]. b p<0.05 vs controls; c p<0.01 vs controls, d p<0.001 vs controls (unpaired t tests). Unpaired t tests were performed in the case of a significant ANOVA test (p<0.05). CLA, conjugated linoleic acid; t10c12CLA, trans10cis12CLA