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A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family

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Abstract

Dominant markers have been commonly used in mapping quantitative trait loci (QTLs) in outcrossing species, in which not much prior genome information is available. But the dominant nature of these markers may lead to reduced QTL mapping precision and power. A new statistical method is proposed to incorporate growth laws into a QTL mapping framework, under which the use of the efficiency of dominant markers can be increased. This new method can be used to identify specific QTLs affecting differentiation in growth trajectories, and further estimate the timing of a QTL to turn on, or turn off, affecting growth during the entire ontogeny of a species. Using this method based on dominant markers we have successfully mapped a QTL for stem height growth trajectories to a linkage group in a forest tree. The implications of this method for the understanding of the genetic architecture of growth using dominant markers are discussed.

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Acknowledgements

We thank two anonymous referees for their constructive comments on this manuscript. This work is supported by an Outstanding Young Investigator Award (30128017) of the National Natural Science Foundation of China, a University of Florida Research Opportunity Fund (02050259), and a University of South Florida Biodefense grant (7222061-12) to R. W. The publication of this manuscript was approved as Journal Series No. R-09204 by the Florida Agricultural Experiment Station.

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Authors and Affiliations

  1. Department of Statistics, University of Florida, 533 McCarty Hall C, Gainesville, FL 32611, USA

    C.-X. Ma, M. Lin, R. C. Littell & R. Wu

  2. The Key National Laboratory of Forest Genetics and Gene Engineering, Nanjing Forestry University, Jiangsu 210037, Nanjing, P. R. China

    T. Yin

  3. Laboraty of Statistical Genetics, Zhejiang Forestry College, Lin’An, Zhejiang 311300, P. R. China

    R. Wu

Authors
  1. C.-X. Ma
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  2. M. Lin
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  3. R. C. Littell
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  4. T. Yin
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  5. R. Wu
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Corresponding author

Correspondence to R. Wu.

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Communicated by F. Salamini

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Ma, CX., Lin, M., Littell, R.C. et al. A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family. Theor Appl Genet 108, 699–705 (2004). https://doi.org/10.1007/s00122-003-1484-9

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  • DOI: https://doi.org/10.1007/s00122-003-1484-9

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