Zusammenfassung
Hintergrund
Die Mind-body-Medizin (MBM) ergänzt die somatisch orientierte medizinische Praxis um verhaltens- und lebensstilorientierte Ansätze: So werden gesundheitsfördernde Haltungen und Verhaltensweisen im Alltag gestärkt. Als ein Bestandteil der integrativen Onkologie hilft sie, emotionales und körperliches Wohlbefinden zu fördern.
Fragestellung
Leitlinienempfehlungen und die aktuelle Studienlage in der integrativen Uroonkologie werden vorgestellt.
Ergebnisse
Während und nach Abschluss der primären Therapie zeigt die achtsamkeitsbasierte Stressreduktion (MBSR) positive Effekte auf Angst, Stress und Fatigue. Es zeigt sich jedoch, dass das Angebot besser auf die Bedürfnisse von Prostatakrebspatienten zugeschnitten werden muss. Gut belegt sind die Effekte von Yoga insbesondere auf Fatigue, Lebensqualität und die sexuelle Funktion. Prostatakarzinompatienten zeigten nach Abschluss einer Yogaintervention auch eine deutlich erhöhte Immunantwort. Tai Ji Quan/Qigong verbessern Lebensqualität, Fatigue und weitere Symptome. Hypnose – insbesondere in der Palliativsituation – mildert Ängste, und Entspannungsverfahren lindern Schlafprobleme und Übelkeit/Erbrechen. Multimodale Angebote verbessern die Lebensqualität auf zahlreichen Ebenen. Eine höhere Resilienz korreliert mit besserer Lebensqualität und stärkerem männlichem Selbstwertgefühl.
Schlussfolgerungen
Die MBSR lindert viele Symptome, muss aber auf die Bedürfnisse von Prostatakarzinompatienten angepasst werden. Yoga und Tai Ji Chuan/Qigong lindern Fatigue und bessern die Lebensqualität. Hypnose und Entspannungstraining mindern Übelkeit/Erbrechen, verbessern Schlaf und Ängstlichkeit. Zur Unterstützung der onkologischen Patienten ist Resilienzförderung wichtig.
Abstract
Background
Mind-body medicine (MBM) complements somatically oriented medical practice with behavioral and lifestyle-oriented approaches: Thus, health-promoting attitudes and behaviors are strengthened in everyday life. In integrative oncology, it helps promote emotional and physical well-being.
Research question
Guideline recommendations and the current study situation in integrative uro-oncology are presented.
Results
During and after completion of primary therapy, mindfulness-based stress reduction (MBSR) shows positive effects on anxiety, stress, and fatigue. However, it appears that the offer needs to be better tailored to the needs of prostate cancer patients. The effects of yoga are well documented, especially on fatigue, quality of life, and sexual function. Prostate cancer patients also showed a significantly increased immune response after completing a yoga intervention. Tai Ji Quan/Qigong improve quality of life, fatigue, and other symptoms. Hypnosis—especially in the palliative setting—mitigates anxiety, and relaxation techniques alleviate sleep problems and nausea/vomiting. Multimodal services improve quality of life on numerous levels. Higher resilience correlates with better quality of life and stronger male self-esteem.
Conclusions
MBSR alleviates many symptoms but needs to be adapted to the needs of prostate cancer patients; yoga and Tai Ji Chuan/Qigong alleviate fatigue and improve quality of life. Hypnosis and relaxation training reduce nausea/vomiting, and improve sleep and anxiety. Resilience promotion is important to support oncological patients.
Literatur
Bollinger JW (2018) The rate of adverse events related to hypnosis during clinical trials. Am J Clin Hypn 60(4):357–366
Brugnoli MP, Pesce G, Pasin E et al (2018) The role of clinical hypnosis and self-hypnosis to relief pain and anxiety in severe chronic diseases in palliative care: a 2-year long-term follow-up of treatment in a nonrandomized clinical trial. Ann Palliat Med 7(1):17–31
Cebolla A, Demarzo M, Martins P et al (2017) Unwanted effects: Is there a negative side of meditation? A multicentre survey. PLoS ONE 12(9):e183137
Chambers SK, Occhipinti S, Foley E et al (2017) Mindfulness-based cognitive therapy in advanced prostate cancer: a randomized controlled trial. J Clin Oncol 35(3):291–297
Charalambous A, Giannakopoulou M, Bozas E et al (2016) Guided imagery and progressive muscle relaxation as a cluster of symptoms management intervention in patients receiving chemotherapy: a randomized control trial. PLoS ONE 11(6):e156911
Chen P, Liu YM, Chen ML (2017) The effect of hypnosis on anxiety in patients with cancer: a meta-analysis. Worldviews Evid Based Nurs 14(3):223–236
Cramer H, Ward L, Saper R et al (2015) The safety of yoga: a systematic review and meta-analysis of randomized controlled trials. Am J Epidemiol 182(4):281–293
Cramer H, Lauche R, Langhorst J et al (2016) Is one yoga style better than another? A systematic review of associations of yoga style and conclusions in randomized yoga trials. Complement Ther Med 25:178–187
Culos-Reed N, Dew M, Zahavic A, Wilson K, Amason T, Mackenzie M, Brissette C, Van Patten C, Santa Mina D (2018) Development of a community wellness program for prostate cancer survivors. Transl J ACSM 3(13):97–106
Dobos G, Overhamm T, Bussing A et al (2015) Integrating mindfulness in supportive cancer care: a cohort study on a mindfulness-based day care clinic for cancer survivors. Support Care Cancer 23(10):2945–2955
Egger S, Hughes S, Smith DP et al (2018) Factors associated with the use of complementary and alternative medicines for prostate cancer by long-term survivors. PLoS ONE 13(3):e193686
Farber F, Rosendahl J (2018) The association between resilience and mental health in the somatically ill. Dtsch Arztebl Int 115(38):621–627
Frankland J, Brodie H, Cooke D et al (2019) Follow-up care after treatment for prostate cancer: evaluation of a supported self-management and remote surveillance programme. BMC Cancer 19(1):368
Groarke A, Curtis R, Skelton J et al (2020) Quality of life and adjustment in men with prostate cancer: interplay of stress, threat and resilience. PLoS ONE 15(9):e239469
Haller H, Winkler MM, Klose P et al (2017) Mindfulness-based interventions for women with breast cancer: an updated systematic review and meta-analysis. Acta Oncol 56(12):1665–1676
Harorani M, Davodabady F, Farahani Z et al (2020) The effect of Benson’s relaxation response on sleep quality and anorexia in cancer patients undergoing chemotherapy: a randomized controlled trial. Complement Ther Med 50:102344
Harorani M, Noruzi Zamenjani M, Golitaleb M et al (2020) Effects of relaxation on self-esteem of patients with cancer: a randomized clinical trial. Support Care Cancer 28(1):405–411
Hilfiker R, Meichtry A, Eicher M et al (2018) Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis. Br J Sports Med 52(10):651–658
Jeitler M, Jaspers J, von Scheidt C et al (2017) Mind-body medicine and lifestyle modification in supportive cancer care: a cohort study on a day care clinic program for cancer patients. Psychooncology 26(12):2127–2134
Kalisch R, Muller MB, Tuscher O (2015) A conceptual framework for the neurobiological study of resilience. Behav Brain Sci 38:e92
Kaushik D, Shah PK, Mukherjee N et al (2022) Effects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial. Prostate Cancer Prostatic Dis 25(3):531–538
Lahart IM, Metsios GS, Nevill AM et al (2015) Physical activity, risk of death and recurrence in breast cancer survivors: a systematic review and meta-analysis of epidemiological studies. Acta Oncol 54(5):635–654
Lewson AB, Johns SA, Krueger E et al (2021) Symptom experiences in post-treatment cancer survivors: associations with acceptance and commitment therapy constructs. Support Care Cancer 29(7):3487–3495. https://doi.org/10.1007/s00520-020-05854-7
Linz SH, Kunzler I, Chmitorz A, Lieb A, Kubiak K (2020) Interventionen zur Resilienzförderung bei Erwachsenen. Psychother Psychosom Med Psychol 70:11–21
Ludolph P (2019) Resilienzfördernde Interventionen bei Patienten mit Krebs. Dtsch Arztebl Int 116:865–872. https://doi.org/10.3238/arztebl.2019.0865
McAteer G, Gillanders D (2019) Investigating the role of psychological flexibility, masculine self-esteem and stoicism as predictors of psychological distress and quality of life in men living with prostate cancer. Eur J Cancer Care (Engl) 28(4):e13097
Ni X, Chan RJ, Yates P et al (2019) The effects of Tai Chi on quality of life of cancer survivors: a systematic review and meta-analysis. Support Care Cancer 27(10):3701–3716
Paul A, Cramer H, Lauche R et al (2013) An oncology mind-body medicine day care clinic: concept and case presentation. Integr Cancer Ther 12(6):503–507
Paul A, Lange S, Voiß P (2019) Integrative Onkologie an den Kliniken Essen-Mitte. In: Dobos G, Paul A (Hrsg) Mind-Body-Medizin, 2. Aufl. Elsevier, München, S 225–235
Scandurra C, Mangiapia F, La Rocca R et al (2022) A cross-sectional study on demoralization in prostate cancer patients: the role of masculine self-esteem, depression, and resilience. Support Care Cancer 30(8):7021–7030
Victorson D, Hankin V, Burns J et al (2017) Feasibility, acceptability and preliminary psychological benefits of mindfulness meditation training in a sample of men diagnosed with prostate cancer on active surveillance: results from a randomized controlled pilot trial. Psychooncology 26(8):1155–1163
Wayne PM, Berkowitz DL, Litrownik DE et al (2014) What do we really know about the safety of tai chi? A systematic review of adverse event reports in randomized trials. Arch Phys Med Rehabil 95(12):2470–2483
Daubenmier JJ, Weidner G, Ornish D et al (2006) Lifestyle and health-related quality of life of men with prostate cancer managed with active surveillance. Urology 67(1):125–130
Frattaroli J, Weidner G, Dnistrian AM et al (2008) Clinical events in prostate cancer lifestyle trial: results from two years of follow-up. Urology 72(6):1319–1323. https://doi.org/10.1016/j.urology.2008.04.050
Ornish D, Weidner G, Fair WR et al (2005) Intensive lifestyle changes may affect the progression of prostate cancer. J Urol 174(3):1065–1070
Ornish D, Magbanua MJ, Weidner G et al (2008) Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Proc Natl Acad Sci USA 105(24):8369–8374
Ornish D, Lin J, Chan JM et al (2013) Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5‑year follow-up of a descriptive pilot study. Lancet Oncol 14(11):1112–1120. https://doi.org/10.1016/S1470-2045(13)70366-8
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P. Voiß erklärt, dass sie innerhalb der vergangenen 3 Jahre ein Stipendium von der Karl und Veronica Carstens-Stiftung und durch das Josepha und Charlotte von Siebold Habilitandinnenförderprogramm sowie Beraterhonorare von Novartis und WALA und Vortragshonorare von Novartis, Pfizer, Celgene, Lilly, Seagen und Roche erhalten hat. P. Klose, M. Werner und F. Saha geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
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Klose, P., Werner, M., Saha, F. et al. Mind-body-Medizin in der integrativen Uroonkologie. Urologie 62, 27–33 (2023). https://doi.org/10.1007/s00120-022-01978-2
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DOI: https://doi.org/10.1007/s00120-022-01978-2