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Der Urologe

, Volume 57, Issue 3, pp 295–299 | Cite as

„Watchful waiting“ und aktive Überwachung kleiner Nierentumoren

  • R. Mager
  • S. Frees
  • A. Haferkamp
Leitthema

Zusammenfassung

Die Inzidenz kleiner Nierenzellkarzinome ≤4 cm steigt mit der ausgedehnten Nutzung von Schnittbildgebung. Die Tumoren weisen meist wenig Aggressivität auf, wobei das Risiko der Metastasierung trotzdem bis zu 6 % betragen kann. Insbesondere für alte komorbide Patienten könnte eine Operation somit eine schädigende Übertherapie darstellen. Die Etablierung einer onkologisch sicheren aktiven Überwachung gewinnt in dieser Situation zunehmend an Bedeutung, so dass klinische, radiologische und biopsiebasierte biologische Marker für die Auswahl und die Überwachung geeigneter Patienten aktuell im Fokus der Forschung stehen.

Schlüsselwörter

Biopsie Nierenzellkarzinom Biomarker Metastasen Mutationen 

Watchful waiting and active surveillance of small renal masses

Abstract

The incidence of small renal masses ≤4 cm is increasing due to the widespread use of cross-sectional imaging. The majority of these represent indolent forms, but the risk for developing metastases is reported in up to 6% of patients. Particularly in old and comorbid patients surgery might be harmful overtreatment. Thus, there is an increasing demand to establish oncologically safe active surveillance protocols. Radiographic or biopsy-based biological markers to appropriately designate candidates for active surveillance are currently the focus of research.

Keywords

Biopsy Renal cell carcinoma Biomarkers Neoplasm metastasis Mutations 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

R. Mager, S. Frees und A. Haferkamp geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Klinik und Poliklinik für Urologie und KinderurologieUniversitätsmedizin MainzMainzDeutschland

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