Zusammenfassung
Die Tumorprophylaxe an der Prostata ist theoretisch einfach – schwierig ist jedoch, dass keine entsprechenden Testmethoden zur Verfügung stehen. Das Thema: „Prostatakarzinomprophylaxe durch Nahrungsergänzungsmittel“ bleibt schwierig. Noch gibt es keine wirklich sicheren Daten. Der psychologische Aspekt, selbst aktiv zum Erfolg einer Therapie beitragen zu wollen und zu können, ist durchaus ein nicht zu vernachlässigender Aspekt, solche Nahrungsergänzungsmittel zu akzeptieren. Und es gibt Studien, die zeigen, dass ein gewisser hilfreicher Effekt vorhanden zu sein scheint. Aus diesen Überlegungen heraus entsteht die Frage, ob man nicht sogar eine Karzinomprophylaxe daraus entwickeln könnte. Nachfolgend wird der Stand im Frühjahr 2014 vorgestellt.
Abstract
Prophylaxis of tumors of the prostate gland is theoretically simple but what makes it difficult is that no appropriate test methods are available. The topic of prostate cancer prophylaxis by dietary supplements remains difficult as there are still no really certain data. The psychological aspect of wanting and being able to actively contribute to success of a therapy oneself, is absolutely not an aspect to be ignored to accept such dietary supplements. There are also studies which show that a certain helpful effect seems to be present. From these considerations the question arises whether cancer prophylaxis could be developed from this. This article presents the state of the art in early 2014.
Notes
Kernaussagen werden in der Literatur angegeben, Details sind der Originalliteratur zu entnehmen.
Literatur
Lippman SM, Klein EA, Goodman P et al (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301(2):39–51
Merkle W (2010) Prophylaxis and treatment of prostate cancers by nutrition supplements: a clinician’s view of facts and hope after the SELECT study. UIJ 9(1). doi:10.3834luij.1944-5784.2010.02.13
Lu Y, Zhai L, Zeng J et al (2014) Coffee consumption and prostate cancer risk: an updated meta-analysis. Cancer Causes Control 25(5):591–604. doi:10.1007/s10552-014-0364-B
Itsiopoulos C, Hodge A, Kaimakis M (2009) Can the Mediterranean diet prevnt prostate cancer? Mol Nutr Food Res 53(2):227–239
Schmid H-P, Fischer C, Enegler DS et al (2011) Nutritional aspects of primary prostate cancer prevention. Recent Results Cancer Res 188:101–107
Grainger EM, Schwartz SJ, Wand S et al (2008) A combination of tomato and soy products form en with recurring prostate cancer and rising prostate specific antigen. Nutr Cancer 60(2):145–141
Wilson KM, Bälter K, Möller E et al (2013) Coffee and risk of prostate cancer incidence and mortality in the cancer of the prostate in Sweden study. Cancer Causes Control 24(8):1575–1581
Geybels MS, Neuhouser ML, Wright JL et al (2013) Coffee and tea consumption in relation to prostate cancer prognosis. Cancer Causes Control 24(11):1947–1954
Li Q, Kakizaki M, Sugawara Y et al (2013) Coffee consumption and the risk of prostate cancer: the Ohasi cohort study. Br J Cancer 108(11):2381–2389
MNT (2014) Pomgranate, green tea, turmeric and broccoli may help fight prostate cancer. MNT, London, http://www.medicalnewstoday.com/articles/261688.php
Mayo-Klinik (2014) Prostate cancer prevention: ways to reduce your risk. Mayo-Klinik. http://www.mayoclinic.org
Adjakly M, Ngollo M, Boiteux JP et al (2013) Genistein and daidzein: different molecular effects on prostate cancer. Anticancer Res 33(1):39–44
Chiyomaur T, Yamamury S, Fukuhara S et al (2013) Genistein up-regulates tumor suppression microRNA-574-3p in prostate cancer. PLoS One 8(3):58929
Hörmann V, Kuni-Diaka J, Durity M et al (2012) Anticancer activities of genistein-topotecan combination in prostate cancer cells. J Cell Mol Med 16(11):2631–2636
Zhang W, Wang Y, Chen T et al (2013) Genistein enhances the efficacy of cabazitaxel chemotherapy in metastatic castration-resistent prostate cancer cells. Prostate 73(15):1681–1689
NCI (2013) Pomegranate: prostate cancer, nutrition and dietary supplements (PDQ). NCI, Bethesda. http://www.cancer.gov
Senner-Liewen F, Liewen H, Cathomas R et al (2013) Dialy pomegranate intake has no impact on PSA leves in patients with advanced prostate cancer – results of a phase IIb randomized controlled trial. J Cancer 4(7):597–605
NCI (2013) Green Tea. Prostate cancer, nutrition and dietary supplements (PDQ). NCI, Bethesda. http://www.cancer.gov
Teichert F, Verschoyle RD, Greaves P et al (2010) Plasma metabolic profiling reveals age-dependeny of systemic effects of green tea polyphenols in mice with and without prostate cancer. Mol Biosyst 6(10):1911–1916
Bettuzzi S, Brausi M, Rizzi F et al (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grde prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of principle study. Cancer Res 66(2):1234–1240
Jatoi A, elision N, Burch PA et al (2003) a phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma. Cancer 97(6):1442–1446
Boehm K, Borrellei F, Ernst E et al (2009) Green tea (Camellia sinensis) fopr the prevention of cancer. Cochrane Database Syst Rev 3:CD005004
Montaguy JA, Butler LM, Wy AH et al (2012) Green an black tea intake in relation to prostate cancer risk among Singapore Chinese. Cancer Causes Control 23(10):1635–1641
Kavitha C, Deep G, Gangar S et al (2014) Silibinin inhibits prostate cacner cells- and RANKL-induced osteoclastogenessis by targetin NFATc1, NF-kappaB and AP-1 activation in RAW264.7 cells. Mol Carcinog 53(3):169–180
Ting H, Deep G, Agarwal R (2013) Molecular mechanisms of silibinin-mediated cancer chemoprevention with major emphasis on prostate cancer. AAPS J 15(3):707–716
Wu K, Zeng J, Zhu GD et al (2009) Silibinin inhibits prostate cacner invation, motility and migration by suppression viemntin and MMP-2 epxpression. Acta Pharmacol Sin 30(8):1162–1168
Li G, Rivas P, Bedolla R et al (2013) Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/s6K axis. Cancer Prev Res (Phila) 6(1):27–39
Ganapathy S, Chen Q, Singh K et al (2010) Resveratrol enhances antitumor ectivity of TRAIL in prostate cancer xenografty through activation of FOXO transcription factor. PLoS One 5(12):15627
Jeaong NY, Yoon G, Rho JH et al (2011) The novel resveratrol analo HS-1793-induced polyploidy LNCaP prostate cancer cells are vulnerabl to downregulation ob Bcl-xL. Int J Oncol 38(6):1597–1604
Klink JC, Tewar AK, Masko EM et al (2013) Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through prardoxical effets on oncogenic pathwasy. Prostate 73(7):754–762
Chan HT, Chou CT, Chen IL et al (2013) Mechanisms of resveratrol-induced changes in [Ca(2+)]I and cell viability in PC3 human prostate cancer cells. J Recept Signal Transduct Res 333(5):298–303
Sheth S, Jajoo S, Kaur T et al (2012) Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway. PLoS One 7(12):51655
Iguchi K, Toyama T, Ito T et al (2012) Antiandrogenic activity of resveratrol analogs in prostate cancer LNCaP cells. J Androl 33(6):1208–1215
Kai L, Levenson AS (2011) Combination of resveratrol and antiandrogen flutamide ha synergistic effect on androgen receptor inhibition in prostate cancer cells. Anticancer Res 31(10):3323–3330
Kim DH, Hossain MA, Kim MY et al (2013) A novel resveratrol analoge, HS-1793, inhibis hypocia-induces HIF-1alpha and VEGF expression, and migration in human prostate cancer cells. Int J Oncol 43(6):1915–1924
Dhar S, Hicks C, Levension AS (2011) Resveratrol and prostate cancer: primision role for microRNAs. Mol Nutr Food Res 55(8):1219–1229
Chen Q, Ganapathy S, Sing KP et al (2010) Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One 5(12):15288
Narayanan NK, Nargi D, Randolph C et al (2009) Liposoe encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer 125(1):1–8
Gupta SC, Patchva S, Aggarwal BB (2013) Therapeutiv roles or curcumin: lesions learned from clinical trials. AAPS J 15(1):195–218
Cretju E, Trifan A, Vasincu AI et al (2010) Plant-derived anticancer agents – curcumin in cancer prevention and treatment. Rev Med Chir Soc Med Nat Iasi 13(4):343–349
Wei Y, Zhou D, Wand H et al (2012) Effects of pyridine analogs of curcumin on growth, apoptosis and NF-kappaB activity in prostate cancer PC-3 cells. Anticancer Res 116(4):1223–1229
Teiten MH, Gaascht F, Cronaur M et al (2011) Antiproliferative ptential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. Int J Oncol 38(3):603–611
Sundram V, Chauhen SC, Ebeling M et al (2012) Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinease D1. PLoS One 7(4):35368
Fajardo AM, MacKenzie DA, Ji M et al (2012) The curcumin analog ca27 dow-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells. Prostate 72(6):612–625
Guo H, Xu YM, Ye ZQ et al (2013) Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulation the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie 68(6):431–434
Cheng TA, Chen WC, Lin YY et al (2013) Curcumin-targeting pericellular serine protease matriptase rol in suppression of prostate cancer cell invation tumor growth and metastasis. Cancer Prev Res (Phila) 6(5):495–505. doi:10.1007/s/104953013-0947-y
Ide H, Tokiwa S, Sakamaki K et al (2010) Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate 70(10):1127–1133
Gardner CD, Oelrich B, Liu JP et al (2009) Prostatic sy isoflavone concentrations exceed serum levels after dieatary supplementation. Prostate 69(7):719–726
Yatkin E, Polari L, Laajala TD et al (2014) Novel lignan an stilbenoid misture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model. PLoS One 9(4):93764
Peuhu E, Rivero-Müller A, Stykki H et al (2010) Inhibition of AKT signaling by the lignan matairenisl sensitizes prostate cancer cells to TRAIL-induced apoptosis. Oncogene 29(6):898–908
Zhou YJ, Liu YE, Cao JG et al (2009) Viexins, nature-derived lignin compounds induce apoptosis and suppress tumor growth. Clin Cancer Res 15(16):5161–5189
Azrad M, Vollmer RT, Madden J et al (2013) Flaxseed-derived enterolactone is inversely asiciatde with tumor cell proliferation in men with localize prostate cancer. J Med Food 16(4):357–360
Goodman M, Bostick RM, Ward KC et al (2006) Lycopene intake and prostate cancer risk: effect modification by plasma antioxidants and the XRCC1 genotype. Nutr Cancer 55:13–20
Zhang X, Wang Q, Neil B et al (2010) Effect of lycopene on androgen receptor and prostate-specifig antigen velocity. Chin Med J (Engl) 123(16):2231–2236
KIM HS, Bowen P, Chen L et al (2003) Effects of tomato sauce comsumption on apoptotic cell death in prostate benign hyperplasia and cancer. Nutr Cancer 47(1):40–47
Tang Y, Parmaktiar B, Simoneau AR et al (2011) Lykopene enhances docetaxel’s effect in castration-resistent prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia 13(2):108–119
Ilic D, Forbes KW, Hassed C (2011) Lycopene for the prevention of prostate cancer. Cochrane Database Syst Rev 11:CD008007
Zu K, Mucci L, Rosner BA et al (2014) Dietary lycopene, angiogenesis and prostate cancer: a prospective study in the prostate-specifi antigen era. J Natl Cancer Inst 106(2):430
Soares NCP, Teodoro AJ, Oliveira FL et al (2013) Influence of lycopene on cell viability cell cycle and apoptosis of human prostate cancer and benign hyperplastic cells. Nutr Cancer 65(7):1076–1085
Ford NA, Elsen AC, Zuniga K et al (2011) Lycopene and apo-12’-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells. Nutr Cancer 64(2):256–263
Holzapfel NP, Holzapfel BM, Champ S et al (2013) The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanism to clinical evidence. Int J Mol Sci 14(7):14620–14646
Konijeti R, Henning S, Moro A et al (2010) Chemoprecvention of prostate cancer with lycopene in the TRAMP model. Prostate 70(14):1547–1554
Ilic D (2014) Lycopene for the prevention and treatment of prostate disease. Recent Results Cancer Res 202:109–114
Haseen F, Cantwell MM, O’Sullivan JM et al (2009) Is there a benefit from lycopene supplementation in man with prostate cancer? A systematic review. Prostate Cancer Prostatic Dis 12(4):325–332
Talvas J, Caris-Veyrat C, Guy L et al (2010) Differential effects of lycopene consumed in tomato paste and lycopene in the form of a purified extract on target genes of cancer prostatic cells. Am J Clin Nutr 123(16):2231–2236
Vaishampayan U, Hussain M, Banerjee M et al (2007) Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr Cancer 59(1):1–7
Trejo-Solis C, Pedraza-Chaverri J, Torres-Ramos M et al (2013) Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Evid Based Complement Alternat Med 2013:705121
Altavilla D, Bitto A, Plito F et al (2011) The combination of serenoa repens, selenium and lycopene is more effective than serenoa repens alone to prevent hormone dependent prostatic growth. J Urol 186(4):1524–1529
Paluuy P, Colangelo M, Simone R et al (2010) Lycopene induces cell growth inhibition by altering mevalonate pathway and ras signaling in cancer cell lines. Carcinogenesis 31(10):1813–1821
NIH (2013) Fish oil. NIH, Bethesda. http://www.nlm.nih.gov
Medscape (2013) Prostate cancer and Nutrition. Drug & Reference information. Medscape, New York. http://www.medscape.com
Huffingtonpost (2013) Recent study implicates omega-3 fatty acids in prostate cancer: is there reliable information? Huffingtonpost, Huffington. http://www.huffingtonpost.com. Zugegriffen: 07. Juli 2013
Szymanski KM, Wheeler DC, Mucci LA et al (2010) Fish consumption and prostate cancer risk: a review and meta-analysis. Am J Clin Nutr 92:1223–1233
Lifeextension (2013) Fish and prostate cancer risk: fact of fiction. Lifeextension, Fort Lauderdale. http://www.lef.org
Simon S (2014) Omega-3 fatty acids links to increase in prostate cancer risk. ACS, Atlanta. http://www.cancer.org
Atawodi SE (2011) Nigerian foodstuffs with prostate cancer chemopreventive polyphenoles. Infect Agent Cancer 6(Suppl 2):99
Abdulah R, Kobayashi K, Yamazaki C et al (2011) Molecular targets of selenium in prostate cancer prevention (review). Int J Oncol 39(2):301–309
Christensen MJ, Qunier TE, Nakken HL et al (2013) Combination effects of dietary soy and methlsenenocysteine in a mouse model of prostate cancer. Prostate 73(9):986–995
Dennert G, Zwahlen M, Brinkmann M et al (2011) Selenium for preventing cancer. Cochrane Database Syst Rev 5:CD005195
Lunoe K, Gabel-Jensen C, Stürüp S et al (2011) Investigation oft he selenium metabolism in cancer cell lines. Metallomics 3(2):162–168
Takata Y, Morris JS, King IB et al (2009) Correlation between selenium concentrations and glutathione peroxidase activity in serum and human prostate tissue. Prostate 69(15):1635–1642
Gundimes U, Schiffman JE, Chhabra D et al (2008) Locally generated methylselenic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem 283(50):34519–34531
Steinbecher A, Mapln C, Hesketh J et al (2010) Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study on European men. Cancer Epidemiol Biomarkers Prev 19(11):2958–2968
Geybels MS, Hutter CM, Kwon EM et al (2013) Variation in selenoenzyme genes and prostate cancer risk and survival. Prostate 73(7):734–742
Penney KL, Li H, Micci LA et al (2013) Selenoprotein P genetic variants and mrna expression; circulating selenium, and prostate cancer risk and survival. Prostate 73(7):700–705
Chan JM, Oh WK, Xie W et al (2009) Plasma selenium, manganese superoxide dismutase and intermediate- or high-risk prostate cancer. J Clin Oncol 27(22):3577–3583
Hurst R, Hooper L, Norat T et al (2012) Selenium and prostate cancer: systematic review and meta-analysis. Am J Clin Nutr 96(1):111–122
Stratton MA, Algotar AM, Ranger-Moore J et al (2010) Oral selenium supplementation has no effect on prostate-specific antigen velocity in men undergoing active surveillance for localized prostate cancer. Cancer Prev Res (Phila) 3(8):1035–1043
Rayman MP, Combs GF Jr, Waters DJ (2009) Selenium and vitamin E supplementation for cancer prevention. JAMA 301(18):1876–1877
Geybels MA, Verhage Bas AJ, Schooten FJ van et al (2013) Advanced prostate cancer risk in relation to toenail selenium levels. J Natl Cancer Inst 105(18):13941401
Bauer CM, Ishak MB, Johnson EK et al (2012) Prevalence and correlates of vitamin and supplement usage among men with a family history of prostate cancer. Integr Cancer Ther 11(2):83–89
Philippou Y, Hadjipavlou M, Khan S et al (2013) Complementary and alteranative medicine (CAM) in prostate and bladder cancer. BJU Int 112(8):1073–1079
Paschos A, Pandya R, Cuivenvoorden WCM et al (2013) Oxidatvie stress in prostate cancer: changing research concepts towards a noval prardigm for prevention and therapeutics. Prostate Cancer Prostatic Dis 16(3):217–225
Huncharek M, Muscat J, Kupelnick B (2009) Colorectal cancer risk and dietary intake of calcium, Vitamin D and diary products: a meta-analysis of 26335 cases from 60 observational studies. Nutr Cancer 61(1):47–69
Van Veldhiuzen PJ, Taylor SA, Williamson S et al (2000) Treatmen of vitamin D deficiency in patients with metastaic prostate cancer may improve bone pain and muscle strength. J Urol 163:187–190
Wactawski-Wende J, Kotchen JM, Anderson GL et al (2006) Women’s health initative investigators. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 354:684–696
AACR (2012) Oral vitamin D supplements reduced levels of Ki67 in prostate cancer cells. AACR, Philadelphia. http://www.sciencedaily.com. Zugegriffen: 31.03.2012
Hsu JW, Yasmin-Karim S, King MR et al (2011) Suppression of prostate cancer cll rolling an dadhesion to entothelium by 1,25-dihydroxyviatmin D3. Am J Pathol 178(2):872–880
Zheng Y, Zhou H, Ooi LL et al (2011) Vitamin D deficiency promotes prostate cancer growth in bone. Prostate 71(9):1012–1021
Gavrilov V, Leibovich Y, Ariad S et al (2010) A combined pretreatment of 1,15-dihydroxyvitamin D3 and sodium valproate enhances the damaging effect of ionized radiation on prostatic cancer cells. J Steroid Biochem Mol Biol 121(1–2):391–394
Holt SK, Kwon EM, Koopmeiners JS et al (2010) Viatmin D pathway gene variants and prostate cancer prognosis. Prostate 70(13):1448–1460
Newson-Davis TE, Kenny LM, Ngan S et al (2009) The promiscuous receptor. BJU Int 104(9):1204–1207
Klein EA, Thompson IM, Tangen CM et al (2011) Vitamin E and the risk of prostate cancer (SELECT). JAMA 306(14):1549–1556. https://jama.jamanetwork.com
Okamoto R, Delansome R, Wakimoto N et al (2012) Inecacitol, an analog of 1α,25 (OH)(2) D(3), induces growth arrest of androgen-dependent prostate cancer cells. Int J Cancer 130(10):2464–2473. doi:10.1002/ijc.26279
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Interessenkonflikt. W. Merkle gibt an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
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Merkle, W. Prostatakarzinomprophylaxe durch Nahrungsergänzungsmittel. Urologe 53, 1610–1619 (2014). https://doi.org/10.1007/s00120-014-3614-1
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DOI: https://doi.org/10.1007/s00120-014-3614-1