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Personalisierte Uroonkologie auf der Grundlage einer molekularen Uropathologie

Was ist die Zukunft?

Personalized urooncology based on molecular uropathology

What is the future?

Zusammenfassung

Die durch zielgerichtete Therapien und Biomarkervalidierung forcierte Weiterentwicklung der personalisierten Onkologie ist in allen klinischen Bereichen auf dem Vormarsch. Verglichen mit anderen Fächern wie der Pneumologie und der Gynäkologie war die Entwicklung in der Urologie bisher verhalten, gewinnt aber seit kurzen zunehmend an Dynamik. Mit eine Grundlage hierfür ist die derzeit wachsende und zukünftig noch beschleunigte Anwendung neuer molekularbiologischer Erkenntnisse in der Uropathologie. Dabei wird der rasche Erkenntnisgewinn vorangetrieben durch eine ganz neue Klasse von Analyseverfahren, wie der hochparallelen Sequenzierung („deep sequencing“ oder „next generation sequencing“), die quasi einen neuen „Kosmos“ von potentiellen Biomarkern verfügbar machen. In diesem Beitrag möchten wir den sich abzeichnenden Paradigmenwechsel in der molekularpathologischen Diagnostik urologischer Tumore am Beispiel des Prostatakarzinoms aufzeigen.

Abstract

Targeted therapies and biomarker validation are key drivers in the advancement of personalized oncology which is a growing topic in all clinical areas. Compared with other professions, such as pulmonology and gynecology, development in urology has so far been retarded but has recently gained increasing momentum. A basis for this is the currently growing and in future accelerated application of new knowledge derived from molecular biology in the field of uropathology. The rapid gain of knowledge is driven by a whole new class of analytical methods, such as massively parallel sequencing (deep sequencing or next generation sequencing), which enables analysis of virtually a new universe of potential biomarkers. This article describes the emerging paradigm shift in molecular pathological diagnostics of urological tumors using the example of prostate cancer.

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Correspondence to E. Dahl or F. Haller.

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Dahl, E., Haller, F. Personalisierte Uroonkologie auf der Grundlage einer molekularen Uropathologie. Urologe 52, 976–981 (2013). https://doi.org/10.1007/s00120-013-3229-y

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  • DOI: https://doi.org/10.1007/s00120-013-3229-y

Schlüsselwörter

  • Personalisierte Medizin
  • Uroonkologie
  • Biomarker
  • „Next generation sequencing“
  • Prostatakarzinom

Keywords

  • Personalized medicine
  • Urooncology
  • Biomarkers
  • Next generation sequencing
  • Prostate cancer