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Die Bedeutung der chronischen Prostatitis für die Pathogenese des Prostatakarzinoms

The significance of chronic prostatitis for the etiopathology of prostate cancer

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Zusammenfassung

Obwohl dem Prostatakarzinom als Krankheitsbild des Mannes eine große epidemiologische Bedeutung zukommt, sind noch zahlreiche Zusammenhänge insbesondere zu seiner Pathogenese weitgehend unbekannt. Einen neuen und derzeit intensiv untersuchten Ansatz bietet ein bereits in verschiedenen anderen Organen untersuchtes Phänomen – die Kanzerogenese im Rahmen chronischer Entzündungsprozesse. Die vorliegende Übersichtsarbeit stellt den aktuellen Forschungsstand der Zusammenhänge zwischen chronischer Prostatitis und dem Prostatakarzinom vor und diskutiert hierbei neben den histologischen und biochemischen Kriterien außerdem jüngste Entdeckungen, welche die Pathogenese des Prostatakarzinoms, ähnlich dem HPV-assoziierten Zervixkarzinom, in Zusammenhang mit einer Infektion durch das neuartige Gammaretrovirus XMRV bringen.

Abstract

Although prostate cancer is of crucial impact as a common disease of men, numerous relationships remain unknown, particularly concerning its pathogenesis. A novel approach regarding the origin and development of prostate cancer is a phenomenon that has already been investigated in other human cancers: cancerogenesis due to chronic inflammation. Hence, the present review introduces the current state of research concerning the relationship between chronic prostatitis and prostate cancer. In addition to histological and biochemical features, the latest discoveries are discussed, including the relationship between the pathogenesis of prostate cancer and infection by the novel gammaretrovirus XMRV, similar to cervical cancer associated with HPV.

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  1. Institut für Pathologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Deutschland

    D. Wittschieber, S. Schenkenberg, M. Dietel & A. Erbersdobler

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  1. D. Wittschieber
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  2. S. Schenkenberg
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  3. M. Dietel
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  4. A. Erbersdobler
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Correspondence to D. Wittschieber.

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Wittschieber, D., Schenkenberg, S., Dietel, M. et al. Die Bedeutung der chronischen Prostatitis für die Pathogenese des Prostatakarzinoms. Urologe 49, 947–951 (2010). https://doi.org/10.1007/s00120-010-2284-x

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  • DOI: https://doi.org/10.1007/s00120-010-2284-x

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