Skip to main content
Log in

Prostatitis und Prostatakarzinom

Prostattic inflammation and prostate cancer

  • Leitthema
  • Published:
Der Urologe Aims and scope Submit manuscript

Zusammenfassung

Eine Vielzahl von Karzinomen wird durch eine chronische Inflammation hervorgerufen. Auch beim Prostatakarzinom scheint die chronische Entzündung/Inflammation eine wichtige Bedeutung in der Karzinogenese zu spielen. Ziel dieser Arbeit ist es, die epidemiologischen, morphologischen, molekularbiologischen und klinischen Aspekte der Prostatitis und des Prostatakarzinoms zu beleuchten.

Abstract

Chronic inflammation seems of importance in multiple types of cancer. Numerous reports have revealed a potential link between chronic prostatatic inflammation and prostate cancer. The aim of this paper is to review the epidemiological, moprphological, molecular and clinical aspects of prostattic inflammation and prostate cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. De Marzo AM, Platz EA, Sutcliffe S et al (2007) Inflammation in prostate carcinogenesis. Nat Rev Cancer 7:256–269

    Article  Google Scholar 

  2. Wagenlehner FM, Elkahwaji JE, Algaba F et al (2007) The role of inflammation and infection in the pathogenesis of prostate carcinoma. BJU Int 100:733–737

    Article  CAS  PubMed  Google Scholar 

  3. Nickel JC, Downey J, Hunter D, Clark J (2001) Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index. J Urol 165:842–845

    Article  CAS  PubMed  Google Scholar 

  4. Daniels NA, Ewing SK, Zmuda JM et al (2005) Correlates and prevalence of prostatitis in a large community-based cohort of older men. Urology 66:964–970

    Article  PubMed  Google Scholar 

  5. Dennis LK, Lynch CF, Torner JC (2002) Epidemiologic association between prostatitis and prostate cancer. Urology 60:78–83

    Article  PubMed  Google Scholar 

  6. Bastian PJ, Carter BH, Bjartell A et al (2009) Insignificant prostate cancer and active surveillance: from definition to clinical implications. Eur Urol 55:1321–1330

    Article  PubMed  Google Scholar 

  7. De Marzo AM, Marchi VL, Epstein JI, Nelson WG (1999) Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol 155:1985–1992

    Google Scholar 

  8. Shah R, Mucci NR, Amin A et al (2001) Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander? Am J Pathol 158:1767–1773

    CAS  PubMed  Google Scholar 

  9. Bastian PJ, Yegnasubramanian S, Palapattu GS et al (2004) Molecular biomarker in prostate cancer: the role of CpG island hypermethylation. Eur Urol 46:698–708

    Article  CAS  PubMed  Google Scholar 

  10. Nelson WG, De Marzo AM, Isaacs WB (2003) Prostate cancer. N Engl J Med 349:366–381

    Article  CAS  PubMed  Google Scholar 

  11. Nakayama M, Bennett CJ, Hicks JL et al (2003) Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am J Pathol 163:923–933

    CAS  PubMed  Google Scholar 

  12. Bardia A, Platz EA, Yegnasubramanian S et al (2009) Anti-inflammatory drugs, antioxidants and prostate cancer prevention. Curr Opin Pharmacol 9:419–426

    Article  CAS  PubMed  Google Scholar 

  13. Ames BN, Gold LS, Willett WC (1995) The causes and prevention of cancer. Proc Natl Acad Sci USA 92:5258–5265

    Article  CAS  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to P.J. Bastian.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bastian, P., Nuhn, P., Stadler, T. et al. Prostatitis und Prostatakarzinom. Urologe 49, 636–638 (2010). https://doi.org/10.1007/s00120-010-2254-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00120-010-2254-3

Schlüsselwörter

Keywords

Navigation