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Kryoablation des lokalisierten Prostatakarzinoms

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Cryoablation of localized prostate cancer

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Zusammenfassung

Die kontinuierliche technische Entwicklung über mehr als ein halbes Jahrhundert und daraus resultierende bessere klinische Ergebnisse bei geringerer Nebenwirkungsrate haben die Kryoablation der Prostata zu einer echten Alternative bei der Behandlung des lokalisierten Prostatakarzinoms bei selektionierten Patienten werden lassen. Die heutige Form der Kryotherapie hat fast nichts mehr mit der in den 1960er und 1970er Jahren entwickelten und in den 1980er und 1990er Jahren verbesserten Variante gemeinsam. Die heutige minimale Invasivität und hohe Wirksamkeit bei High-risk-Karzinomen zum einen und Versagern anderer therapeutischer Modalitäten zum anderen ergeben ein Anwendungsspektrum bei absoluter oder relativer Kontraindikation zur radikalen Operation. In der Salvagesituation bei noch lokalisiertem Prostatakarzinom ist die Kryoablation derzeit Therapie der Wahl. Nicht zuletzt wurde dieser Stellenwert durch eine Standardisierung der Prozedur, exakte Definition des Ablaufs und strukturierte Trainingsprogramme erreicht.

Abstract

Due to continuous technical developments for more than half a century followed by better clinical results with minimal side effects, cryoablation of the prostate for localized prostate cancer has evolved as a true alternative therapeutic option in selected cases. The current version of cryoablation has almost nothing in common with those versions established in the 1960s and 1970s and further developed in the 1980s and 1990s. The present version is minimally invasive and has a high efficacy for treatment of high risk carcinomas and failure of other therapeutic modalities. Cryoablation of the prostate is indicated if there are absolute or relative contraindications for radical surgery. In salvage cases cryoablation is the therapy of choice for localized prostate cancer. Standardization of the procedure, definition of freeze-thaw cycles and structured training programs have led to this status.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung hin: Trainer für 17-G-Nadel-Kryotherapie. Trotz des möglichen Interessenkonflikts ist der Beitrag unabhängig und produktneutral.

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  1. Klinik für Urologie und Kinderurologie, Krankenhaus Nordwest GmbH, Stiftung Hospital zum Heiligen Geist, Steinbacher Hohl 2-26, 60488, Frankfurt/Main , Deutschland

    U.K.F. Witzsch & E. Becht

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  1. U.K.F. Witzsch
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  2. E. Becht
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Correspondence to U.K.F. Witzsch.

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Witzsch, U., Becht, E. Kryoablation des lokalisierten Prostatakarzinoms. Urologe 48, 719–728 (2009). https://doi.org/10.1007/s00120-009-1985-5

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  • DOI: https://doi.org/10.1007/s00120-009-1985-5

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