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Statine und Probiotika in der Prävention urologischer Erkrankungen

Statins and probiotics in the prevention of urologic diseases

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Zusammenfassung

Statine hemmen die 3-Hydroxy-3-Methylglutaryl-CoA-Reduktase und reduzieren damit die Synthese von Cholesterin. Neben dieser Wirkung haben sie möglicherweise einen chemopräventiven Effekt auf das Prostatakarzinom, der in experimentellen Ansätzen gut belegt ist. Epidemiologische Studien an Patienten mit Prostatakarzinom zeigen ebenfalls eine protektive Wirkung der Statine, die Datenlage ist jedoch noch nicht stabil.

Probiotika sind Präparationen aus lebensfähigen Bakterienkulturen und werden zur Nahrungsergänzung angeboten. Sie haben nicht nur protektive Wirkungen bei Harnweginfektionen und bei Hyperkalzurie, sondern sind auch beim experimentell induzierten Blasenkarzinom effektiv. Entsprechende Daten zum oberflächlichem Blasenkarzinom und zum Kolonkarzinom liegen aus klinischen Studien vor.

Abstract

Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, better known as statins, may be associated with reduced prostate cancer risk. Statins have been reported to demonstrate chemopreventive potentials in prostate cancer cell lines, but the association in observational studies has been inconclusive.

Probiotics, defined as live microbial food supplements, have been tested for an impact on a variety of clinical conditions, e.g., urinary tract infections and calcium oxalate stone disease. Furthermore, oral administration of a lactic acid bacterium was effective against experimentally induced bladder tumors. Relationships between cancer and intake of probiotics have mainly been studied in bladder and colon cancer.

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Authors and Affiliations

  1. Klinik für Urologie und Kinderurologie, Klinikum Bayreuth GmbH, Hohe Warte 8, 95445, Bayreuth, Deutschland

    C. Fischer

  2. Chirurgische Klinik Bogenhausen, München, Deutschland

    J. Altwein

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  1. C. Fischer
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  2. J. Altwein
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Correspondence to C. Fischer.

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Fischer, C., Altwein, J. Statine und Probiotika in der Prävention urologischer Erkrankungen. Urologe 46, 622–627 (2007). https://doi.org/10.1007/s00120-007-1341-6

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  • DOI: https://doi.org/10.1007/s00120-007-1341-6

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