Zusammenfassung
Lebensqualität und die Verhinderung von Komplikationen stehen bei Patienten mit fortgeschrittenem Prostatakarzinom zunehmend im Vordergrund. Neben der Beherrschung lokaler Probleme wie Obstruktion, Makrohämaturie oder Lymphödemen nimmt dabei die Behandlung ossärer Metastasen und deren Komplikationen einen wichtigen Stellenwert ein. Analgetische Maßnahmen, Bisphosphonate, Strahlentherapie, enossale Schmerztherapie und neurochirurgische Verfahren stehen zur Verfügung. Eine Spinalkanalkompression mit akuten motorischen oder sensorischen Ausfällen bedarf sofortiger neurochirurgischer und/oder strahlentherapeutischer Behandlung. Eine bestehende Tumoranämie sollte adäquat behandelt werden.
Abstract
In patients with advanced prostate cancer, quality of life and prevention of complications come to the fore. Besides handling local complications such as obstruction, hematuria and lymphedema, treatment of bone metastases and their complications is of great importance. Analgesic measures, bisphosphonates, radiation therapy, radionuclide therapy and neurosurgical procedures are available. Spinal cord compression with acute motor and sensory deficiency requires immediate neurosurgical and/or radiation therapy. Tumor anemia should be treated appropriately.
Literatur
Marszalek M, Ponholzer A, Rauchenwald M, Madersbacher S (2006) Palliative transurethral resection of the prostate: functional outcome and impact on survival. BJU Int 99(1): 56–59
Crain DS, Amling CL, Kane CJ (2004) Palliative transurethral prostate resection for bladder outlet obstruction in patients with locally advanced prostate cancer. J Urol 171: 668–671
Chang CC, Kuo JY, Chen KK et al. (2006) Transurethral prostatic resection for acute urinary retention in patients with prostate cancer. J Chin Med Assoc 69: 21–25
Gnanapragasam VJ, Kumar V, Langton D et al. (2006) Outcome of transurethral prostatectomy for the palliative management of lower urinary tract symptoms in men with prostate cancer. Int J Urol 13: 711–715
Kuntz RM (2006) Current role of lasers in the treatment of benign prostatic hyperplasia (BPH). Eur Urol 49: 961–969
Elzayat E, Habib E, Elhilali M (2006) Holmium laser enucleation of the prostate in patients on anticoagulant therapy or with bleeding disorders. J Urol 175: 1428–1432
Uthappa MC, Cowan NC (2005) Retrograde or antegrade double-pigtail stent placement for malignant ureteric obstruction? Clin Radiol 60: 608–612
Laube N, Bradenahl J, Meissner A et al. (2006) Plasma-deposited carbon coating on urological indwelling catheters: Preventing formation of encrustations and consecutive complications. Urologe A 45: 1163–1169
Harris MR, Speakman MJ (2006) Nephrostomies in obstructive uropathy; how should hormone resistant prostate cancer patients be managed and can we predict who will benefit? Prostate Cancer Prostatic Dis 9: 42–44
Romero FR, Broglio M, Pires SR et al. (2005) Indications for percutaneous nephrostomy in patients with obstructive uropathy due to malignant urogenital neoplasias. Int Braz J Urol 31: 117–124
Kirkova J, Oneschuk D, Hanson J (2005) Deep vein thrombosis (DVT) in advanced cancer patients with lower extremity edema referred for assessment. Am J Hosp Palliat Care 22: 145–149
Giess CS, Bach AM, Hann LE (2001) Lower extremity venous sonography in the high-risk cancer population: one leg or two? AJR Am J Roentgenol 176: 1049–1052
Vignes S, Priollet P (2002) Lymphology in 2002. From diagnosis to treatment of lymphedemas. Rev Med Interne 23(Suppl 3): 436–441
Tiwari A, Cheng KS, Button M et al. (2003) Differential diagnosis, investigation, and current treatment of lower limb lymphedema. Arch Surg 138: 152–161
Shrubb D, Mason W (2006) The management of deep vein thrombosis in lymphoedema: a review. Br J Community Nurs 11: 292–297
WHO (1996) Cancer pain relief, 2nd edn. WHO, Genf
Smith MR (2002) Osteoporosis and other adverse body composition changes during androgen deprivation therapy for prostate cancer. Cancer Metastasis Rev 21: 159–166
Oefelein MG, Ricchuiti V, Conrad W et al. (2001) Skeletal fracture associated with androgen suppression induced osteoporosis: the clinical incidence and risk factors for patients with prostate cancer. J Urol 166: 1724–1728
Orwoll E, Ettinger M, Weiss S et al. (2000) Alendronate for the treatment of osteoporosis in men. N Engl J Med 343: 604–610
Smith MR, McGovern FJ, Zietman AL et al. (2001) Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med 345: 948–955
Diamond TH, Winters J, Smith A et al. (2001) The antiosteoporotic efficacy of intravenous pamidronate in men with prostate carcinoma receiving combined androgen blockade: a double blind, randomized, placebo-controlled crossover study. Cancer 92: 1444–1450
Coleman RE, Purohit OP, Vinholes JJ, Zekri J (1997) High dose pamidronate: clinical and biochemical effects in metastatic bone disease. Cancer 80: 1686–1690
Heidenreich A, Hofmann R, Engelmann UH (2001) The use of bisphosphonate for the palliative treatment of painful bone metastasis due to hormone refractory prostate cancer. J Urol 165: 136–140
Saad F, Gleason DM, Murray R et al. (2002) A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 94: 1458–1468
Ernst DS, Tannock IF, Winquist EW et al. (2003) Randomized, double-blind, controlled trial of mitoxantrone/prednisone and clodronate versus mitoxantrone/prednisone and placebo in patients with hormone-refractory prostate cancer and pain. J Clin Oncol 21: 3335–3342
Dearnaley DP, Sydes MR, Mason MD et al. (2003) A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PR05 Trial). J Natl Cancer Inst 95: 1300–1311
Greenberg MS (2004) Intravenous bisphosphonates and osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98: 259–260
Migliorati CA, Schubert MM, Peterson DE, Seneda LM (2005) Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy. Cancer 104: 83–93
Chow E, Wu J, Loblaw A, Perez CA (2003) Radiotherapeutic approaches to metastatic disease. World J Urol 21: 229–242
Nagata M, Ueda T, Komiya A et al. (2003) Treatment and prognosis of patients with paraplegia or quadriplegia because of metastatic spinal cord compression in prostate cancer. Prostate Cancer Prostatic Dis 6: 169–173
Tazi H, Manunta A, Rodriguez A et al. (2003) Spinal cord compression in metastatic prostate cancer. Eur Urol 44: 527–532
Hoskin PJ, Grover A, Bhana R (2003) Metastatic spinal cord compression: radiotherapy outcome and dose fractionation. Radiother Oncol 68: 175–180
Rades D, Stalpers LJ, Veninga T et al. (2005) Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression. J Clin Oncol 23: 3366–3375
Maranzano E, Bellavita R, Rossi R et al. (2005) Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial. J Clin Oncol 23: 3358–3365
Finlay IG, Mason MD, Shelley M (2005) Radioisotopes for the palliation of metastatic bone cancer: a systematic review. Lancet Oncol 6: 392–400
Sartor O (2003) Radioisotopic treatment of bone pain from metastatic prostate cancer. Curr Oncol Rep 5: 258–262
Pandit-Taskar N, Batraki M, Divgi CR (2004) Radiopharmaceutical therapy for palliation of bone pain from osseous metastases. J Nucl Med 45: 1358–1365
Bauman G, Charette M, Reid R, Sathya J (2005) Radiopharmaceuticals for the palliation of painful bone metastasis-a systemic review. Radiother Oncol 75: 258–270
Maini CL, Sciuto R, Romano L, Bergomi S (2003) Radionuclide therapy with bone seeking radionuclides in palliation of painful bone metastases. J Exp Clin Cancer Res 22: 71–74
Byrne TN, Borges LF, Loeffler JS (2006) Metastatic epidural spinal cord compression: update on management. Semin Oncol 33: 307–311
Klimo P Jr, Thompson CJ, Kestle JR, Schmidt MH (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neurooncology 7: 64–76
Cella D (2006) Quality of life and clinical decisions in chemotherapy-induced anemia. Oncology (Williston Park) 20: 25–28
Littlewood TJ, Nortier J, Rapoport B et al. (2003) Epoetin alfa corrects anemia and improves quality of life in patients with hematologic malignancies receiving non-platinum chemotherapy. Hematol Oncol 21: 169–180
Wild C, Jonas S (2001) Health policy decisions between rationing and rationalization – exemplified by erythropoietin in tumor anemia. Gesundheitswesen 63: 221–225
Seidenfeld J, Piper M, Flamm C et al. (2001) Epoetin treatment of anemia associated with cancer therapy: a systematic review and meta-analysis of controlled clinical trials. J Natl Cancer Inst 93: 1204–1214
Tannock IF, de Wit R, Berry WR et al. (2004) Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 351: 1502–1512
Petrylak DP, Tangen CM, Hussain MH et al. (2004) Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 351: 1513–1520
Interessenkonflikt
Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Maurer, T., Retz, M. & Gschwend, J. Palliative und supportive Therapie bei Patienten mit fortgeschrittenem Prostatakarzinom. Urologe 46, 30–35 (2007). https://doi.org/10.1007/s00120-006-1271-8
Issue Date:
DOI: https://doi.org/10.1007/s00120-006-1271-8