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Hirnmetastasen beim Nierenzellkarzinom

Brain metastases in cases of renal cell carcinoma

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Zusammenfassung

Hirnmetastasen sind die am häufigsten auftretenden intrakranialen Neoplasien. Meist sind es Metastasen von Lungen-, Brust- oder Nierentumoren. Das Auftreten von Krämpfen und neurologischen Ausfällen stellen die typischen klinischen Manifestationen der zerebralen Dissemination dar, welche unbehandelt in wenigen Monaten zum Tod führt. In dieser Übersicht besprechen wir die aktuellen therapeutischen Optionen der Hirnmetastasen ausgehend vom Nierenzellkarzinom. Dies sind im Einzelnen: Ganzhirnbestrahlung, chirurgische Resektion und stereotaktische Radiochirurgie.

Abstract

Brain metastases represent the most common intracranial neoplasia. The lung, breast and kidney are the primary tumor locations most often associated with brain metastasis. Seizures and neurological impairment are typical manifestations of neoplastic cerebral dissemination, which, when untreated, usually lead to death within a few months. In this review, we discuss whole brain radiotherapy, surgical resection and stereotactic radiosurgery as the currently used therapeutic options for renal cell cancer metastasis in the brain.

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Literatur

  1. Alexander E 3rd, Moriarty TM, Davis RB et al. (1995) Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst 87: 34–40

    PubMed  Google Scholar 

  2. Andrews DW, Scott CB, Sperduto PW et al. (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363: 1665–1672

    Article  PubMed  Google Scholar 

  3. Aoyama H, Shirato H, Tago M et al. (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. Jama 295: 2483–2491

    Article  PubMed  Google Scholar 

  4. Chidel MA, Suh JH, Barnett GH (2000) Brain metastases: presentation, evaluation, and management. Cleve Clin J Med 67: 120–127

    PubMed  Google Scholar 

  5. Decker DA, Decker VL, Herskovic A, Cummings GD (1984) Brain metastases in patients with renal cell carcinoma: prognosis and treatment. J Clin Oncol 2: 169–173

    PubMed  Google Scholar 

  6. Flickinger JC, Kondziolka D, Lunsford LD et al. (1994) A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys 28: 797–802

    PubMed  Google Scholar 

  7. Hasegawa T, Kondziolka D, Flickinger JC et al. (2003) Brain metastases treated with radiosurgery alone: an alternative to whole brain radiotherapy? Neurosurgery 52: 1318–1326

    Article  PubMed  Google Scholar 

  8. Lagerwaard FJ, Levendag PC, Nowak PJ et al. (1999) Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. Int J Radiat Oncol Biol Phys 43: 795–803

    Article  PubMed  Google Scholar 

  9. Manon R, O’Neill A, Knisely J et al. (2005) Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oncology Group study (E 6397). J Clin Oncol 23: 8870–8876

    Article  PubMed  Google Scholar 

  10. Maor MH, Frias AE, Oswald MJ (1988) Palliative radiotherapy for brain metastases in renal carcinoma. Cancer 62: 1912–1917

    Article  PubMed  Google Scholar 

  11. Mintz AH, Kestle J, Rathbone MP et al. (1996) A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 78: 1470–1476

    Article  PubMed  Google Scholar 

  12. Mori Y, Kondziolka D, Flickinger JC et al. (1998) Stereotactic radiosurgery for brain metastasis from renal cell carcinoma. Cancer 83: 344–353

    Article  PubMed  Google Scholar 

  13. Muacevic A, Kreth FW, Horstmann GA et al. (1999) Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter. J Neurosurg 91: 35–43

    PubMed  Google Scholar 

  14. Muacevic A, Kreth FW, Mack A et al. (2004) Stereotactic radiosurgery without radiation therapy providing high local tumor control of multiple brain metastases from renal cell carcinoma. Min Invas Neurosurg 47: 203–208

    Article  Google Scholar 

  15. Muacevic A, Siebels M, Tonn JC, Wowra B (2005) Treatment of brain metastases in renal cell carcinoma: radiotherapy, radiosurgery, or surgery? World J Urol 23: 180–184

    Article  PubMed  Google Scholar 

  16. Noel G, Valery CA, Boisserie G et al. (2004) LINAC radiosurgery for brain metastasis of renal cell carcinoma. Urol Oncol 22: 25–31

    PubMed  Google Scholar 

  17. Patchell RA, Tibbs PA, Regine WF et al. (1998) Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. Jama 280: 1485–1489

    Article  PubMed  Google Scholar 

  18. Patchell RA, Tibbs PA, Walsh JW et al. (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322: 494–500

    Google Scholar 

  19. Payne BR, Prasad D, Szeifert G et al. (2000) Gamma surgery for intracranial metastases from renal cell carcinoma. J Neurosurg 92: 760–765

    PubMed  Google Scholar 

  20. Pomer S, Klopp M, Steiner HH et al. (1997) Brain metastases in renal cell carcinoma. Results of treatment and prognosis. Urologe A 36: 117–125

    Article  PubMed  Google Scholar 

  21. Roser F, Rosahl SK, Samii M (2002) Single cerebral metastasis 3 and 19 years after primary renal cell carcinoma: case report and review of the literature. J Neurol Neurosurg Psychiatry 72: 257–258

    Article  PubMed  Google Scholar 

  22. Salvati M, Scarpinati M, Orlando ER et al. (1992) Single brain metastases from kidney tumors. Clinico-pathologic considerations on a series of 29 cases. Tumori 78: 392–394

    PubMed  Google Scholar 

  23. Serizawa T, Iuchi T, Ono J et al. (2000) Gamma knife treatment for multiple metastatic brain tumors compared with whole-brain radiation therapy. J Neurosurg 93(Suppl 3): 32–36

    PubMed  Google Scholar 

  24. Shaw E, Scott C, Souhami L et al. (2000) Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90–05. Int J Radiat Oncol Biol Phys 47: 291–298

    Article  PubMed  Google Scholar 

  25. Sheehan JP, Sun MH, Kondziolka D et al. (2003) Radiosurgery in patients with renal cell carcinoma metastasis to the brain: long-term outcomes and prognostic factors influencing survival and local tumor control. J Neurosurg 98: 342–349

    PubMed  Google Scholar 

  26. Shuto T, Inomori S, Fujino H, Nagano H (2006) Gamma knife surgery for metastatic brain tumors from renal cell carcinoma. J Neurosurg 105: 555–560

    PubMed  Google Scholar 

  27. Sills AK (2005) Current treatment approaches to surgery for brain metastases. Neurosurgery 57: 21–32

    Article  Google Scholar 

  28. Wronski M, Arbit E, Russo P, Galicich JH (1996) Surgical resection of brain metastases from renal cell carcinoma in 50 patients. Urology 47: 187–193

    Article  PubMed  Google Scholar 

  29. Yamanaka K, Gohji K, Hara I et al. (1998) Clinical study of renal cell carcinoma with brain metastasis. Int J Urol 5: 124–128

    PubMed  Google Scholar 

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Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

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Authors and Affiliations

  1. Urologische Universitätsklinik, Ruprecht-Karls-Universität, 69121, Im Neuenheimer Feld 110, Heidelberg, Deutschland

    S. Buse, J. Bedke, M. Kurosch, A. Haferkamp & M. Hohenfellner

  2. Neurochirurgische Klinik, Ruprecht-Karls-Universität, Deutschland, Heidelberg

    A. Unterberg

  3. Abteilung Radioonkologie und Strahlentherapie, Radiologische Klinik, Ruprecht-Karls-Universität, Deutschland, Heidelberg

    K. Herfarth

Authors
  1. S. Buse
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  2. J. Bedke
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  3. M. Kurosch
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  4. A. Haferkamp
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  5. A. Unterberg
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  6. K. Herfarth
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  7. M. Hohenfellner
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Correspondence to S. Buse.

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Buse, S., Bedke, J., Kurosch, M. et al. Hirnmetastasen beim Nierenzellkarzinom. Urologe 46, 36–39 (2007). https://doi.org/10.1007/s00120-006-1267-4

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  • DOI: https://doi.org/10.1007/s00120-006-1267-4

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