Zusammenfassung
Der Wilms-Tumor ist der häufigste Tumor des Urogenitaltraktes im Kindesalter. Er ist ein exzellentes Beispiel für die Effektivität eines multimodalen Therapieansatzes in der Onkologie. Insbesondere die Durchführung internationaler randomisierter Multicenterstudien haben in den letzten Jahrzehnten durch immer weitere Stratifizierung einzelner Therapieelemente zu einer ständigen Verbesserung des tumorfreien Überlebens der betroffenen Patienten geführt. Der Kinderurologe hat über die operative Therapie seinen festen Platz innerhalb des interdisziplinären Vorgehens beim Wilms-Tumor. Zur weiteren Verbesserung der Prognose der Erkrankung und der Reduktion der Komorbidität der Therapie besteht die wichtigste Herausforderung der Kinderurologie in den kommenden Jahren in der Reduktion des operativen Traumas und damit verbunden der Verringerung der perioperativen Komplikationsrate.
Abstract
Wilms tumor is the most frequent malignancy of the urogenital tract in children. Its treatment gives an excellent example of the efficacy of multimodal therapeutic strategies in oncological diseases. In particular, the performance of international, randomized multicenter studies has led to a continuous increase in disease-free survival among the affected patients in recent decades, thanks to increasingly detailed stratification of individual elements of the therapy. The pediatric urologist has a definite place in interdisciplinary teams treating Wilms tumor, being needed for the operative component of the treatment. For further improvement of the prognosis in this disease and to reduce the comorbidity caused by the treatment, the major challenge for pediatric urologists in coming years will be to make the surgery less traumatic and thus also to reduce the incidence and severity of perioperative complications.
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Seseke, F., Gutjahr, P. & Kremens, B. Wilms-Tumor. Urologe 45 (Suppl 4), 235–238 (2006). https://doi.org/10.1007/s00120-006-1199-z
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DOI: https://doi.org/10.1007/s00120-006-1199-z