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Rezidivierende Harnweginfektion der Frau — Diagnostik

Symptomatic urinary tract infection of the female – diagnostics

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Zusammenfassung

Bei der rezidivierenden Zystitis wird die Basis der Diagnostik durch die exakte Anamnese im Wissen um die Pathogenese von Harnweginfekten (HWI) geschaffen. Die Anamnese sollte auch Faktoren, welche die natürliche Vaginalflora beeinflussen (Geschlechtsverkehr, Hygiene), aber auch vorausgegangene Antibiotikabehandlungen und den Immunstatus beeinflussende Erkrankungen (Diabetes mellitus) erfassen.

Im Zentrum der Labordiagnostik steht die Untersuchung des Urins. Die Diagnosesicherung erfolgt zeitnah durch Analyse einer einwandfrei gewonnenen Mittelstrahlprobe im Sofortverfahren (Zählkammer, Teststreifenverfahren). Grundsätzlich folgt immer eine mikrobiologische Diagnostik.

Die erweiterte Diagnostik (urologische Stufendiagnostik) hat zum Ziel, funktionelle und anatomische Veränderungen (Abnormalitäten, komplizierende Faktoren) aufzudecken. Während diese Faktoren prämenopausal nur eine untergeordnete Rolle spielen, gewinnen sie postmenopausal an Bedeutung. Hier kommt dem lokalen Östrogendefizit eine Schlüsselrolle zu.

Abstract

The basis for the diagnostic work-up of recurrent cystitis is formed by taking a precise medical history against the background of knowledge of the pathogenesis of urinary tract infections. The anamnesis should also focus on factors that influence the natural flora (sexual intercourse, hygiene) but additionally include preceding antibiotic treatment and diseases that affect the immune status (diabetes mellitus).

Urinalysis is the principal examination among the laboratory diagnostic procedures. The diagnosis is promptly confirmed by immediate analysis of a clean catch midstream urine sample using a counting chamber or a test strip. As a matter of principle, microbiological diagnosis always ensues.

Extended diagnostic work-up (urological staging) is aimed at detecting functional and anatomic abnormalities. While these factors only play a subordinate role during the premenopausal phase, they gain in importance during the postmenopausal phase. A key role is also attributed to local estrogen deficiency.

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Literatur

  1. Arav-Boger R, Leibovici L, Danon YL (1994) Urinary tract infections with low and high colony counts in young women. Spontaneous remission and single-dose vs multiple-day treatment. Arch Intern Med 154: 300–304

    Article  PubMed  Google Scholar 

  2. Baerheim A, Laerum E (1990) Home-voided urine specimen in women. Diagnostic agreement with clean-catch midstream specimens. Scand J Prim Health Care 8: 207–211

    Google Scholar 

  3. Baerheim A, Digranes A, Hunskaar S (1992) Evaluation of urine sampling technique: bacterial contamination of samples from women students. Br J Gen Pract 42: 241–243

    PubMed  Google Scholar 

  4. Baerheim A, Laerum E (1992) Symptomatic lower urinary tract infection induced by cooling of the feet. Scand J Prim Health Care 10: 157–160

    PubMed  Google Scholar 

  5. Bailey BL (1995) Urinalysis predictive of urine culture results. J Fam Pract: 40: 45–50

    Google Scholar 

  6. Bauer H-W, Haase W, Siek R (1981) Neue diagnostische Möglichkeiten der Urinsedimentanalyse mit dem MD-KOVA-System. Urologe B 21: 295–299

    Google Scholar 

  7. Beyaert G (2004) Mikrobiologie in der urologischen Praxis, 5. Aufl. Hoyer-Madaus, Monheim

  8. Blenk H, Hofstetter AG, Naber KG, Vahlensiek W Jr (1997) Klinische Mikrobiologie für den Urologen. Springer, Berlin Heidelberg New York

  9. Bruns T (1997) Leitlinie „Diagnostik der Infektionen des Urogenitaltraktes“ der Deutschen Gesellschaft für Urologie. Urologe A 5: 487–489

    Google Scholar 

  10. Christiaens TCM, Meyere MD, Derese A (1998) Disappointing specificity of the leucocyte-esterase test for the diagnosis of urinary tract infection in general practice. Eur J Gen Pract 4: 144–147

    Google Scholar 

  11. Fihn SD, Johnson C, Stamm WE (1988) Escherichia coli urethritis in women with symptoms of acute urinary tract infection. J Infect Dis 157: 196–199

    PubMed  Google Scholar 

  12. Fowler JE, Pulaski ET (1981) Excretory urography, cystography and cystoscopy in the evaluation of women with urinary-tract infection. N Engl J Med 304: 462–465

    PubMed  Google Scholar 

  13. Garnjost A (1994) Neues Verfahren zur quantitativen Harnsedimentuntersuchung. Urologe B 34: 363–366

    Google Scholar 

  14. Gatermann S, Podschun R, Schmidt H, Wittke J-W, Naber K, Sietzen W, Straube E (1997) MIQ2 Harnwegsinfektionen. In: Mauch H, Lütticken R, Gatermann S (Hrsg) MIQ Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik. Fischer, Stuttgart Jena Lübeck Ulm, S 1–26

  15. Geerlings SE, Stalk RP, Camps MJL et al. (2000) Asymptomatic bacteriuria may be considered a complication in women with diabetes. Diabetes Care 23: 744–749

    PubMed  Google Scholar 

  16. Goldsmith BM, Campos JM (1990) Comparison of urine dipstick, microscopy, and culture for the detection of bacteriuria in children. Clin Pediatr 29: 214–218

    Google Scholar 

  17. Guttman D, Naylor GRE (1967) Dip-slide: an aid to quantitative urine culture in general practice. Br Med J: 1967: 343–345

  18. Hesse A, Smarsly D (1994) Mikroskopische Harnsedimentuntersuchung. TW Urologie Nephrologie 6: 163–166

    Google Scholar 

  19. Hooton T (1990) The epidemiology of urinary tract infection and the concept of significant bacteriuria. Infection 18(Suppl 2): 40–43

    Article  PubMed  Google Scholar 

  20. Ikaheime R, Siitonen A, Heiskanen T et al. (1996) Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women. Clin Infect Dis 22: 91–99

    PubMed  Google Scholar 

  21. Immergut MA, Gilbert EC, Frensilli FJ, Goble M (1981) The myth of the clean catch urine specimen. Urology 17: 339–340

    Article  PubMed  Google Scholar 

  22. Kahlmeter G (2000) The ECO SENS Projekt: a prospective, multinational, multicentre epidemiological survey of the prevalence and antimicrobial susceptibility of urinary tract pathogens – interim report. J Antimicrobial Chemother 46(Suppl1): 15–22

    Article  Google Scholar 

  23. Kass EH (1957) Bacteriuria and the diagnosis of infections of the urinary tract. Arch Intern Med 100: 709–714

    Google Scholar 

  24. Kunin CM, White LV, Hua TH (1993) A reassessment of the importance of „low-count“ bacteriuria in young women with acute urinary symptoms. Ann Intern Med 119: 454–460

    PubMed  Google Scholar 

  25. Lipsky BA, Inui TS, Plorde JJ, Berger RE (1984) Is the clean-catch midstream void procedure necessary for obtaining urine culture specimens from men? Am J Med 76: 257–262

    Article  PubMed  Google Scholar 

  26. Maskell R (1995) Broadening the concept of urinary tract infection. Br J Urol 76: 2–8

    PubMed  Google Scholar 

  27. Naber KG (1999) Qualitätsstandards in der mikrobiologischen Diagnostik von Harnwegsinfektionen. Urologe B 39: 342–343

    Article  Google Scholar 

  28. Nicolle LE, Ronald AR (1998) Recurrent urinary tract infection and its prevention. In: Brumfitt W, Hamilton-Miller JMT, Bailey RR (eds) Urinary tract infections. Chapman & Hall, Cambridge, pp 293–301

  29. Raz R (2001) Postmenopausal women with recurrent UTI. Int J Antimicrob Agents 17: 269–271

    Article  PubMed  Google Scholar 

  30. Rubin UH, Shapiro ED, Andriole VT et al. (1992) Evaluation of new anti-infective drugs for the treatment of UTI. Clin Infect Dis 15(Suppl 1): 216–227

    Google Scholar 

  31. Smith HS, Hughes JP, Hooton TM et al. (1997) Antecedent antimicrobial use increases the risk of uncomplicated Cystitis in young women. Clin Infect Dis 25: 63–68

    PubMed  Google Scholar 

  32. Stamm WE, Wagner KF, Amsel R et al. (1980) Causes of the acute urethral syndrome in women. N Engl J Med 303: 409–415

    PubMed  Google Scholar 

  33. Stamm WE, Hooton TM (1993) Management of urinary tract infection in adults. N Engl J Med 329: 1328–1334

    Article  PubMed  Google Scholar 

  34. Vogel F, Naber KG, Wacha H et al. (1999) Parenterale Antibiotika bei Erwachsenen. Chemother J 8(1): 3–49

    Google Scholar 

  35. Winkens RA, Leffers P, Trienekens TA, Stobberingh EE (1995) The validity of urine examination for urinary tract infections in daily practice. Fam Pract 12: 290–293

    PubMed  Google Scholar 

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Bruns, T., Piechota, H. & Schneede, P. Rezidivierende Harnweginfektion der Frau — Diagnostik. Urologe 45, 421–428 (2006). https://doi.org/10.1007/s00120-006-1026-6

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