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Therapie der akuten unkomplizierten Harnweginfektion

Therapy of the acute uncomplicated urinary tract infection

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Zusammenfassung

Die akute unkomplizierte Zystitis und die akute unkomplizierte Pyelonephritis stellen zwei häufige Harnweginfektionen (HWI) bei prämenopausalen, ansonsten gesunden Frauen dar. Neuere Untersuchungen belegen, dass die Inzidenz dieser Infektionen höher als erwartet ist. Umfragen zu Gesundheitspraktiken in Nordamerika zeigten eine hohe Variabilität in der Therapie von unkomplizierten HWI. Standardisierte Kriterien für die Diagnose und Therapie unkomplizierter HWI sind deshalb wichtig, um eine ausreichende Sensitivität und Spezifität im klinischen Alltag zu erreichen. Die „Infectious Diseases Society of America“ (IDSA) entwickelte evidenzbasierte Leitlinien für die antibiotische Behandlung von akuter unkomplizierter Zystitis und akuter unkomplizierter Pyelonephritis, die von anderen Expertengremien mit der aktuellen Studienlage abgeglichen wurden.

Abstract

Acute uncomplicated cystitis and acute uncomplicated pyelonephritis are two frequently encountered urinary tract infections (UTI) in premenopausal, healthy females. Recent epidemiological investigations showed that the incidence of these infections is higher than expected. Surveys on healthcare practices in North America revealed a high variability in the therapy of uncomplicated UTI. Standardized criteria for diagnosis and therapy of uncomplicated UTIs therefore are important in order to achieve sufficient sensitivity and specificity in clinical practice. The Infectious Diseases Society of America (IDSA) developed evidence-based guidelines for the treatment of acute uncomplicated cystitis and acute uncomplicated pyelonephritis, which were recently updated by other expert groups.

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Literatur

  1. Ferry SA, Holm SE, Stenlund H, Lundholm R, Monsen TJ (2004) The natural course of uncomplicated lower urinary tract infection in women illustrated by a randomized placebo controlled study. Scand J Infect Dis 36(4): 296–301

    Article  PubMed  Google Scholar 

  2. Christiaens TC, De Meyere M, Verschraegen G, Peersman W, Heytens S, De Maeseneer JM (2002) Randomised controlled trial of nitrofurantoin versus placebo in the treatment of uncomplicated urinary tract infection in adult women. Br J Gen Pract 52(482): 729–734

    PubMed  Google Scholar 

  3. Kahlmeter G (2003) Prevalence and antimicrobial susceptibility of pathogens in uncomplicated cystitis in Europe. The ECO.SENS study. Int J Antimicrob Agents 22 [Suppl 2]: 49–52

    Article  PubMed  Google Scholar 

  4. Kahlmeter G (2003) An international survey of the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections: the ECO.SENS Project. J Antimicrob Chemother 51(1): 69–76

    Article  PubMed  Google Scholar 

  5. Naber KG (1999) Short-term therapy of acute uncomplicated cystitis. Curr Opin Urol 9(1): 57–64

    Article  PubMed  Google Scholar 

  6. Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Stamm WE (1999) Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin Infect Dis 29(4): 745–758

    PubMed  Google Scholar 

  7. Goettsch WG, Janknegt R, Herings RM (2004) Increased treatment failure after 3-days‘ courses of nitrofurantoin and trimethoprim for urinary tract infections in women: a population-based retrospective cohort study using the PHARMO database. Br J Clin Pharmacol 58(2): 184–189

    Article  PubMed  Google Scholar 

  8. Raz R, Chazan B, Kennes Y et al. (2002) Empiric use of trimethoprim-sulfamethoxazole (TMP-SMX) in the treatment of women with uncomplicated urinary tract infections, in a geographical area with a high prevalence of TMP-SMX-resistant uropathogens. Clin Infect Dis 34(9): 1165–1169

    Article  PubMed  Google Scholar 

  9. Minassian MA, Lewis DA, Chattopadhyay D, Bovill B, Duckworth GJ, Williams JD (1998) A comparison between single-dose fosfomycin trometamol (Monuril) and a 5-day course of trimethoprim in the treatment of uncomplicated lower urinary tract infection in women. Int J Antimicrob Agents 10(1): 39–47

    Article  PubMed  Google Scholar 

  10. Henning C, Bengtsson L (1997) Treatment of acute urinary disorders. Simple tests and questions make the diagnosis and therapeutic choices easier. Lakartidningen 94(25): 2387–2390

    PubMed  Google Scholar 

  11. Petersen EE, Wingen F, Fairchild KL et al. (1990) Single dose pefloxacin compared with multiple dose co-trimoxazole in cystitis. J Antimicrob Chemother 26 [Suppl B]: 147–152

    PubMed  Google Scholar 

  12. Jardin A, Cesana M (1995) Randomized, double-blind comparison of single-dose regimens of rufloxacin and pefloxacin for acute uncomplicated cystitis in women. French Multicenter Urinary Tract Infection-Rufloxacin Group. Antimicrob Agents Chemother 39(1): 215–220

    PubMed  Google Scholar 

  13. Del Rio G, Dalet F, Aguilar L, Caffaratti J, Dal-Re R (1996) Single-dose rufloxacin versus 3-day norfloxacin treatment of uncomplicated cystitis: clinical evaluation and pharmacodynamic considerations. Antimicrob Agents Chemother 40(2): 408–412

    PubMed  Google Scholar 

  14. Henry DC Jr, Bettis RB, Riffer E et al. (2002) Comparison of once-daily extended-release ciprofloxacin and conventional twice-daily ciprofloxacin for the treatment of uncomplicated urinary tract infection in women. Clin Ther 24(12): 2088–2104

    Article  PubMed  Google Scholar 

  15. Nicolle LE, Madsen KS, Debeeck GO et al. (2002) Three days of pivmecillinam or norfloxacin for treatment of acute uncomplicated urinary infection in women. Scand J Infect Dis 34(7): 487–492

    Article  PubMed  Google Scholar 

  16. Nicolle LE (2000) Pivmecillinam in the treatment of urinary tract infections. J Antimicrob Chemother 46 [Suppl 1]: 35–65

    Article  Google Scholar 

  17. Kahlmeter G, Menday P (2003) Cross-resistance and associated resistance in 2478 Escherichia coli isolates from the Pan-European ECO.SENS Project surveying the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections. J Antimicrob Chemother 52(1): 128–131

    Article  PubMed  Google Scholar 

  18. Kavatha D, Giamarellou H, Alexiou Z et al. (2003) Cefpodoxime-proxetil versus trimethoprim-sulfamethoxazole for short-term therapy of uncomplicated acute cystitis in women. Antimicrob Agents Chemother 47(3): 897–900

    Article  PubMed  Google Scholar 

  19. Hooton TM, Scholes D, Gupta K, Stapleton AE, Roberts PL, Stamm WE (2005) Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial. JAMA 293(8): 949–955

    Article  PubMed  Google Scholar 

  20. Lecomte F, Allaert FA (1996) Le traitement monodose de la cystite par fosfomycin trometamol. Analyse de 15 essais comparatifs portant sur 2048 malades. Méd Malad Infect 26: 338–343

  21. Schito GC (2003) Why fosfomycin trometamol as first line therapy for uncomplicated UTI? Int J Antimicrob Agents 22 [Suppl 2]: 79–83

    Article  PubMed  Google Scholar 

  22. Guay DR (2001) An update on the role of nitrofurans in the management of urinary tract infections. Drugs 61(3): 353–364

    Article  PubMed  Google Scholar 

  23. Cunha BA (2001) Antibiotic side effects. Med Clin North Am 85(1): 149–185

    Article  PubMed  Google Scholar 

  24. Brumfitt W, Hamilton-Miller JM (1998) Efficacy and safety profile of long-term nitrofurantoin in urinary infections: 18 years‘ experience. J Antimicrob Chemother 42(3): 363–371

    Article  PubMed  Google Scholar 

  25. Karpman E, Kurzrock EA (2004) Adverse reactions of nitrofurantoin, trimethoprim and sulfamethoxazole in children. J Urol 172(2): 448–453

    Article  PubMed  Google Scholar 

  26. Iravani A, Tice AD, McCarty J et al. (1995) Short-course ciprofloxacin treatment of acute uncomplicated urinary tract infection in women. The minimum effective dose. The Urinary Tract Infection Study Group. Arch Intern Med 155(5): 485–494

    Article  PubMed  Google Scholar 

  27. Vogel T, Verreault R, Gourdeau M, Morin M, Grenier-Gosselin L, Rochette L (2004) Optimal duration of antibiotic therapy for uncomplicated urinary tract infection in older women: a double-blind randomized controlled trial. CMAJ 170(4): 469–473

    PubMed  Google Scholar 

  28. Backhouse CI, Matthews JA (1989) Single-dose enoxacin compared with 3-day treatment for urinary tract infection. Antimicrob Agents Chemother 33(6): 877–880

    PubMed  Google Scholar 

  29. Iravani A (1993) Multicenter study of single-dose and multiple-dose fleroxacin versus ciprofloxacin in the treatment of uncomplicated urinary tract infections. Am J Med 94(3A): 89–96

    Google Scholar 

  30. Iravani A CP, Maladorno D (1995) Fleroxacin in the treatment of uncomplicated urinary tract infections in women. 7th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 1995 March 26–30, Vienna, Austria

  31. Richard GA, Mathew CP, Kirstein JM, Orchard D, Yang JY (2002) Single-dose fluoroquinolone therapy of acute uncomplicated urinary tract infection in women: results from a randomized, double-blind, multicenter trial comparing single-dose to 3-day fluoroquinolone regimens. Urology 59(3): 334–339

    Article  PubMed  Google Scholar 

  32. Naber KG, Allin DM, Clarysse L et al. (2004) Gatifloxacin 400 mg as a single shot or 200 mg once daily for 3 days is as effective as ciprofloxacin 250 mg twice daily for the treatment of patients with uncomplicated urinary tract infections. Int J Antimicrob Agents 23(6): 596–605

    Article  PubMed  Google Scholar 

  33. Richard GA, Klimberg IN, Fowler CL, Callery-D’Amico S, Kim SS (1998) Levofloxacin versus ciprofloxacin versus lomefloxacin in acute pyelonephritis. Urology 52(1): 51–55

    Article  PubMed  Google Scholar 

  34. Neringer R, Forsgren A, Hansson C, Ode B (1992) Lomefloxacin versus norfloxacin in the treatment of uncomplicated urinary tract infections: three-day versus seven-day treatment. The South Swedish Lolex Study Group. Scand J Infect Dis 24(6): 773–780

    PubMed  Google Scholar 

  35. Nicolle LE, DuBois J, Martel AY, Harding GK, Shafran SD, Conly JM (1993) Treatment of acute uncomplicated urinary tract infections with 3 days of lomefloxacin compared with treatment with 3 days of norfloxacin. Antimicrob Agents Chemother 37(3): 574–579

    PubMed  Google Scholar 

  36. Spencer RC, Moseley DJ, Greensmith MJ (1994) Nitrofurantoin modified release versus trimethoprim or co-trimoxazole in the treatment of uncomplicated urinary tract infection in general practice. J Antimicrob Chemother 33 [Suppl A]: 121–129

    PubMed  Google Scholar 

  37. The Inter-Nordic Urinary Tract Infection Study Group (1988) Double-blind comparison of 3-day versus 7-day treatment with norfloxacin in symptomatic urinary tract infections. Scand J Infect Dis 20(6): 619–624

    PubMed  Google Scholar 

  38. Piipo TPT, Salo SA (1990) Three-day versus seven-day treatment with norfloxacin in acute cystitis. Curr Ther Res 47: 644–653

    Google Scholar 

  39. Block JM, Walstad RA, Bjertnaes A et al. (1987) Ofloxacin versus trimethoprim-sulphamethoxazole in acute cystitis. Drugs 34 [Suppl 1]: 100–106

    PubMed  Google Scholar 

  40. Hooton TM, Latham RH, Wong ES, Johnson C, Roberts PL, Stamm WE (1989) Ofloxacin versus trimethoprim-sulfamethoxazole for treatment of acute cystitis. Antimicrob Agents Chemother 33(8): 1308–1312

    PubMed  Google Scholar 

  41. Hooton TM, Johnson C, Winter C et al. (1991) Single-dose and three-day regimens of ofloxacin versus trimethoprim-sulfamethoxazole for acute cystitis in women. Antimicrob Agents Chemother 35(7): 1479–1483

    PubMed  Google Scholar 

  42. Naber KG BW, Fischer M, Kresken M (1994) Pefloxacin single-dose in the treatment of acute uncomplicated lower urinary tract infections in women: a meta-analysis of seven clinical trials. Int J Antimicrob Agents 4: 197–202

    Article  Google Scholar 

  43. Menday AP (2002) Symptomatic vaginal candidiasis after pivmecillinam and norfloxacin treatment of acute uncomplicated lower urinary tract infection. Int J Antimicrob Agents 20(4): 297–300

    Article  PubMed  Google Scholar 

  44. Gossius GVL (1985) The treatment of acute dysuria-frequency syndrome in adult women: double-blind, randomized comparison of three-day vs. ten-day trimethoprim therapy. Curr Ther Res 37: 34–42

    Google Scholar 

  45. Kunin C (1997) Detection, prevention and management of UTIs, 5th edn. Lea & Febiger, Philadelphia

  46. Kass E (1956) Asymptomatic infections of the urinary tract. Trans Assoc Am Phys 69: 56–64

    PubMed  Google Scholar 

  47. Hamm M, Wawroschek F, Weckermann D et al. (2001) Unenhanced helical computed tomography in the evaluation of acute flank pain. Eur Urol 39(4): 460–465

    Article  PubMed  Google Scholar 

  48. Stamm WE, McKevitt M, Counts GW (1987) Acute renal infection in women: treatment with trimethoprim-sulfamethoxazole or ampicillin for two or six weeks. A randomized trial. Ann Intern Med 106(3): 341–345

    Google Scholar 

  49. Talan DA, Stamm WE, Hooton TM et al. (2000) Comparison of ciprofloxacin (7 days) and trimethoprim-sulfamethoxazole (14 days) for acute uncomplicated pyelonephritis pyelonephritis in women: a randomized trial. JAMA 283(12): 1583–1590

    Article  PubMed  Google Scholar 

  50. Talan DA, Klimberg IW, Nicolle LE, Song J, Kowalsky SF, Church DA (2004) Once daily, extended release ciprofloxacin for complicated urinary tract infections and acute uncomplicated pyelonephritis. J Urol 171(1): 734–739

    Article  PubMed  Google Scholar 

  51. Naber KG, Bartnicki A, Bischoff W et al. (2004) Gatifloxacin 200 mg or 400 mg once daily is as effective as ciprofloxacin 500 mg twice daily for the treatment of patients with acute pyelonephritis or complicated urinary tract infections. Int J Antimicrob Agents 23 [Suppl 1]: 41–53

    Article  Google Scholar 

  52. Naber KG, Hauke W (2001) Cefpodoxime proxetil in patients with acute uncomplicated pyelonephritis. International, prospective, randomized comparative study versus ciprofloxacin in general practice. Chemother J 10: 29–34

    Article  Google Scholar 

  53. Finkelstein R, Kassis E, Reinhertz G, Gorenstein S, Herman P (1998) Community-acquired urinary tract infection in adults: a hospital viewpoint. J Hosp Infect 38(3): 193–202

    Article  PubMed  Google Scholar 

  54. Nicolle LE (1999) Pivmecillinam for the treatment of acute uncomplicated urinary infection. Int J Clin Pract 53(8): 612–617

    PubMed  Google Scholar 

  55. Bailey RR (1994) Single-dose/short-term therapy in children and in pregnant women. Infection 22 [Suppl 1]: 47–48

    Article  Google Scholar 

  56. Krcmery S, Hromec J, Demesova D (2001) Treatment of lower urinary tract infection in pregnancy. Int J Antimicrob Agents 17(4): 279–282

    Article  PubMed  Google Scholar 

  57. Gilstrap LC 3rd, Cunningham FG, Whalley PJ (1981) Acute pyelonephritis in pregnancy: an anterospective study. Obstet Gynecol 57(4): 409–413

    PubMed  Google Scholar 

  58. Anonymus (2005) Antimicrobials in pregnancy. FDA pregnancy categories. Anonymus

  59. Kämmerer WME (2002) Pharmaka und Schwangerschaft – Eine Übersicht. In: Freise KMF (ed) Arzneimitteltherapie in der Frauenheilkunde. Wissenschaftliche Verlagsgesellschaft, Stuttgart

  60. Kass EH (1960) Bacteriuria and pyelonephritis of pregnancy. Arch Intern Med 105: 194–198

    PubMed  Google Scholar 

  61. Gratacos E, Torres PJ, Vila J, Alonso PL, Cararach V (1994) Screening and treatment of asymptomatic bacteriuria in pregnancy prevent pyelonephritis. J Inf Dis 169: 1390–1392

    Google Scholar 

  62. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM, Infectious Diseases Society of America, American Society of Nephrology, American Geriatric Society (2005) Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 40: 643–654

    Article  PubMed  Google Scholar 

  63. Bailey RR (1994) Single-dose/short-term therapy in children and in pregnant women. Infection 22 [Suppl 1]: 47–48

    Article  Google Scholar 

  64. Villar J, Lydon-Rochelle MT, Gulmezoglu AM, Roganti A (2000) Duration of treatment for asymptomatic bacteriuria during pregnancy. Cochrane Database Syst Rev CD000491

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Wagenlehner, F.M.E., Hoyme, U. & Naber, K.G. Therapie der akuten unkomplizierten Harnweginfektion. Urologe 45, 429–435 (2006). https://doi.org/10.1007/s00120-006-1022-x

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