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Microarrays zur Identifizierung molekularer Marker für Diagnose und Therapie des Nierenzellkarzinoms

Microarrays for the identification of molecular markers in the diagnosis and therapy of renal cell carcinomas

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Zusammenfassung

Im Rahmen der großen interdisziplinären Projekte in der Biologie, insbesondere des Humangenomprojektes, wurden Technologien entwickelt, deren Bedeutung für die Beantwortung klinischer Fragen kaum überschätzt werden kann. Die Technologie der DNA-Microarrays ist hierfür ein klassisches Beispiel: DNA-Microarrays sind hervorragende Werkzeuge für die Untersuchung der globalen Genexpression in Tumoren und normalen Geweben. Sie ermöglichen die Klassifizierung von Tumoren auf der Basis ihrer molekularen Eigenschaften und die Identifizierung neuer Zielstrukturen für neue Therapieansätze. Dieser Beitrag gibt einen Überblick über aktuelle Microarray-Studien zum Nierenzellkarzinom und diskutiert ihre Bedeutung für die Diagnose, Prognose und Therapie dieser Tumorentität.

Abstract

Within the framework of the large interdisciplinary projects in biology, in particular the human genome project, a variety of novel technologies with unprecedented value for the analysis of clinical issues have been developed. DNA microarrays are a prominent example of this: they are powerful tools to investigate global gene expression in tumors and their corresponding normal tissues, to classify tumors based on their molecular properties, and to identify novel targets for future tumor therapy. Here, we review recent results of global gene expression analyses in renal cell carcinoma and discuss their implications for the diagnosis, prognosis, and therapy of human cancer.

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Authors and Affiliations

  1. Abteilung Molekulare Genomanalyse, Deutsches Krebsforschungszentrum Heidelberg

    H. Sültmann & A. Poustka

  2. Abteilung Molekulare Genomanalyse, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120, Heidelberg

    H. Sültmann

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  1. H. Sültmann
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  2. A. Poustka
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Correspondence to H. Sültmann.

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Sültmann, H., Poustka, A. Microarrays zur Identifizierung molekularer Marker für Diagnose und Therapie des Nierenzellkarzinoms. Urologe 45, 297–304 (2006). https://doi.org/10.1007/s00120-006-1003-0

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  • DOI: https://doi.org/10.1007/s00120-006-1003-0

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