Zusammenfassung
Die laparoskopische Lebendspendernephrektomie (LDN) wurde vor 10 Jahren erstmals durchgeführt. Heute wird sie in vielen amerikanischen Zentren routinemäßig praktiziert. In der vorliegenden Arbeit werden die verschiedenen Aspekte der LDN, deren Auswirkungen für Spender, Organ, Empfänger und Operateur evaluiert. Es folgt die Literaturrecherche und -vergleich zum Thema laparoskopische Donornephrektomie und zu den verschiedenen Teilaspekten werden die Besonderheiten dieser Methoden und die eigenen Erfahrungen am aktuell größten deutschen LDN-Zentrum Zentrum (Charité Berlin, Campus Mitte) dargestellt.
Die laparoskopische Nierenentnahme beim lebenden Spender bietet die gleiche Sicherheit wie der offene Eingriff. Gleichzeitig bietet sie multiple Vorteile für den Donor, wie verminderte Schmerzen und kürzere Rekonvaleszenz. Für das gespendete Organ und den Empfänger sind keine Nachteile durch die neue Technik zu erwarten, sofern einige intra- und perioperative Maßnahmen Anwendung finden. Technische Weiterentwicklungen bieten zudem dem Operateur ein mittlerweile breites Armentarium zur optimalen Durchführung der LDN.
Die LDN ist für den Spender, das Organ, den Empfänger und den Operateur sicher. Kernpunkt einer optimalen LDN ist eine ausreichende Erfahrung in laparoskopisch-operativen Techniken und laparoskopischen urologischen Operationen.
Abstract
Ten years ago the first laparoscopic living donor nephrectomy (LDN) was performed. Today, LDN is a routine operation in many US-American transplantation centers and an increasing number of centers in Europe are practicing LDN. In this article the different aspects of LDN for donor, kidney, recipient and operating surgeon are evaluated.
We performed a literature research concerning LDN and the different aspects. Our own experience, as the largest LDN center in Germany, is part of the evaluation.
Laparoscopic extraction of a kidney from a living donor is as safe for the donor as the open approach. At the same time, LDN offers multiple advantages like reduced pain and shorter convalescence. For the donated kidney and the recipient no disadvantages occur from the laparoscopic technique, as long as special intra- and perioperative demands are met. For the operating surgeon multiple developments have expanded the technical armentarium.
LDN is safe for donor, recipient and kidney. Central issue of an optimal LDN is sufficient experience with laparoscopic urological techniques.
Literatur
Bachmann A, Dieckenmann M, Gurke L et al. (2004) Retroperitoneoscopic living donor nephrectomy: a retrospective comparison to the open approach. Transplantation 78: 168–171
Bachmann A, Taquber S, Ruszat R et al. (2005) Ist das kosmetische Ergebnis nach Spendernephrektomie wichtig? Eine retrospektive Befragung von 378 Nierenspendern. Urologe A 44 [Suppl 1]: 46
Buell JF, Edye M, Johnson M et al. (2001) Are concerns over right laparoscopic donor nephrectomy unwarranted? Ann Surg 233: 645–651
Buell JF, Lee L, Martin JE et al. (2005) Laparoscopic donor nephrectomy vs. open live donor nephrectomy: a quality of life and functional study. Clin Transplant 19: 102–109
Carter JT, Freise CE, Mc Taggart RA et al. (2005) Laparoscopic procurement of kidneys with multiple renal arteries is associated with increased ureteral complications in the recipient. Am J Transplant 5: 1312–1318
Conacher ID, Soomro NA, Rix D (2004) Anaesthesia for laparoscopic urological surgery. Br J Anaesth 93: 859–864
Deng DY, Meng MV, Nguyen HT et al. (2002) Laparoscopic linear cutting stapler failure. Urology 60: 415–420
Desai MM, Strzempkowski B, Matin SF et al. (2005) Prospective randomized comparison of transperitoneal versus retroperitoneal laparoscopic radical nephrectomy. J Urol 173: 38–41
Fornara P, Doehn C, Seyfarth M et al. (2000) Why is urological laparoscopy minimally invasive? Eur Urol 37: 241–250
Giessing M, Deger S, Ebeling V et al. (2003) Die laparoskopische transperitoneale Donornephrektomie. Urologe A 42: 218–224
Giessing M, Deger S, Ebeling V (2003) Multiple Nierengefäße bei der laparoskopischen Lebendnierenspende. Urologe A 42: 225–232
Giessing M, Reuter S, Deger S et al. (2005) Laparoscopic versus open donor nephrectomy in Germany: impact on donor health-related quality of life and willingness to donate. Transplant Proc 37: 2011–2015
Giessing M, Türk I, Roigas J et al. (2005) Laparoscopy for living donor nephrectomy —particularities of the currently applied techniques. Transplant Int 18: 1019–1027
Handschin AE, Weber M, Demartines N et al. (2003) Laparoscopic donor nephrectomy. Br J Surg 90: 1323–1332
Hazebroek EJ, de Bruin RW, Bouvy ND et al. (2003) Long-term impact of pneumoperitoneum used for laparoscopic donor nephrectomy on renal function and histomorphology in donor and recipient rats. Ann Surg 237: 351–357
Hazebroek EJ, Gommers D, Schreve MA et al. (2002) Impact of intraoperative donor management on short-term renal function after laparoscopic donor nephrectomy. Ann Surg 236: 127–132
Heimbach JK, Taler SJ, Prieto M et al. (2005) Obesity in living kidney donors: clinical characteristics and outcomes in the era of laparoscopic donor nephrectomie. Am J Transplant 5: 1057–1064
Horgan S, Benedetti E, Moser F (2004) Robotically assisted donor nephrectomy for kidney transplantation. Am J Surg 188: 45–51
Jacobs SC, Cho E, Foster C et al. (2004) Laparoscopic donor nephrectomy: the University of Maryland 6-year experience. J Urol 171: 47–51
Kälble T, Lucan M, Nicita G et al. (2005) EAU Guidelines on renal transplantation. Eur Urol 47: 156–166
Khauli RB (2003) Laparoscopic donor nephrectomy is the future. Transplant Proc 35: 41–42
Kim FJ, Ratner LE, Kavoussi LR (2000) Renal transplantation: laparoscopic live donor nephrectomy. Urol Clin North Am 27: 777–785
Kuo PC, Plotkin JS, Stevens S et al. (2000) Outcomes of laparoscopic donor nephrectomy in obese patients. Transplantation 69: 180–182
Leventhal JR, Kocak B, Salvalaggio PRO et al. (2004) Laparoscopic donor nephrectomy 1997 to 2003: Lessons learned with 500 cases at a single institution. Surgery 136: 881–890
Lind My, Hazebroek EJ, Kirkels WJ et al. (2004) Laparoscopic versus open donor nephrectomy: ureteral complications in recipients. Urology 63: 36–39
Mandal AK, Cohen C, Montgomery RA et al. (2001) Should the indications for laparoscopic live donor nephrectomy of the right kidney be the same as for the open procedure? Anomalous left renal vasculature is not a contraindication to laparoscopic left donor nephrectomy. Transplantation 71: 660–664
Matas AJ, Bartlett ST, Leichtman AB et al. (2003) Morbidity and mortality after living kidney donation, 1991–2001: Survey of united states transplant centers. Am J Transplant 3: 830–834
Melcher ML, Carter JT, Posselt A et al. (2005) More than 500 consecutive laproscopic donor nephrectomies without conversion or repeated surgery. Arch Surg 140: 835–839
Miyake H, Kawabata G, Gotoh A et al. (2002) Comparison of surgical stress between laparoscopy and open surgery in the field of urology by measurement of humoral mediators. Int J Urol 9: 329–333
Odland MD, Ney AL, Jacobs DM (1999) Initial experience with laparoscopic live donor nephrectomy. Surgery 126: 603–607
Parsons JK, Jarrett TJ, Chow GK et al. (2002) The effect of previous abdominal surgery on urological laparoscopy. J Urol 168: 2387–2390
Perry KT, Freedland SJ, Hu JC et al. (2003) Quality of life, pain and return to normal activities following laparoscopic donor nephrectomy versus open mini-incision donor nephrectomy. J Urol 169: 2018–2021
Philosophe B, Kuo PC, Schweitzer EJ et al. (1999) Laparoscopic versus open donor nephrectomy: comparing ureteral complications in the recipients and improving the laparoscopic technique. Transplantation 68: 497–502
Posselt AM, Mahanty H, Kang SM et al. (2004) Laparoscopic right donor nephrectomy: a large single-center experience. Transplantation 78: 1665–1669
Ramani AP, Gill IS, Steinberg AP et al. (2005) Impact of intraoperative heparin on laparoscopic donor nephrectomy. J Urol 174: 226–228
Rassweiler JJ, Wiesel M, Carl S (2001) Laparoskopische Lebendspendernephrektomie — Eigene Erfahrungen und Literaturübersicht. Urologe A 40: 485–492
Ratner, LE, Ciseck LJ, Moore RG et al. (1995) Laparoscopic live donor nephrectomy. Transplantation 60: 1047–1049
Ratner LE, Smith P, Mandal AK et al. (2000) Laparoscopic live donor nephrectomy: pre-operative assessment of technical difficulty. Clin Transplant 14: 427–432
Rawlins MC, Hefty TL, Brown SL et al. (2002) Learning laparoscopic donor nephrectomy safely: a report on 100 cases. Arch Surg 137: 531–534
Schweitzer EJ, Wilson J, Jacobs S et al. (2000) Increased rates of donation with laparoscopic donor nephrectomy. Ann Surg 232: 392–400
Shafizadeh S, McEvoy JR, Murray C (2000) Laparsocopic donor nephrectomy: impact on an established renal transplant program. Am Surg 66: 1132–1135
Simforoosh N, Basiri A, Tabibi A et al. (2005) Comparison of laparoscopic and open donor nephrectomy: a randomized controlled trial. BJU Int 95: 851–855
Slakey DP, Han JC, Rogers E et al. (2002) Single-center analysis of living donor nephrectomy: hand-assisted laparoscopic, pure laparoscopic, and traditional open. Prog Transplant 12: 206–211
Stifelman M, Nieder AM (2002) Prospective comparison of hand-assisted laparoscopic devices. Urology 59: 668–672
Sulser T, Gürke L, Langer I et al. (2004) Retroperitoneoscopic living-donor nephrectomy: first clinical experiences in 19 operations. J Endourol 18: 257262
Sundqvist P, Feuk U, Häggman M et al. (2004) Hand-assisted retroperitoneoscopic live donor nephrectomy in comparison to open and laparoscopic procedures: a prospective study on donor morbidity and kidney function. Transplantation 78: 147–153
Tooher RL, Mohan Rao M, Scott DF et al. (2004) A systematic review of laparoscopic live-donor nephrectomy. Transplantation 78: 404–414
Wilson CH, Bhatti AA, Rix DA et al. (2005) Comparison of laparoscopic and open donor nephrectomy: UK experience. BJU Int 95: 131–135
Wolf JS, Tchetgen MB, Merion RM (1998) Hand-assisted laparoscopic live donor nephrectomy. Urology 52: 885–887
Wullstein C, Woeste G, Bechstein WO (2002) Technik der Lebennierenspende in Deutschland. Transplantationsmedizin 2002 [Suppl]: 135
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Giessing, M., Fuller, T.F., Deger, S. et al. 10 Jahre laparoskopische Lebendnierenspende. Urologe 45, 46–52 (2006). https://doi.org/10.1007/s00120-005-0963-9
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DOI: https://doi.org/10.1007/s00120-005-0963-9