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Das Urothelkarzinom mit trophoblastischer Differenzierung

Eine seltene Tumorvariante am Beispiel einer 77-jährigen Patientin

Urothelium cancer with trophoblastic differentiation

An unusual case of a 77 year old patient

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Zusammenfassung

β-HCG-positive Urothelkarzinome stellen eine seltene Tumordifferenzierung dar. Synzytiotrophoblastische und vereinzelt zytotrophoblastische Riesenzellen sind kennzeichnend. Diese Differenzierung hat ein gesteigertes invasives Potenzial und geht mit einer erhöhten Angioneogenese einher. Die Mischung von trophoblastischen Zellen und Urothelkarzinomzellen im vorliegenden Fall weist auf eine gemeinsame Stammzelle hin.

Die Prognose dieses Tumortyps ist im Vergleich zum markernegativen Karzinom deutlich schlechter. Ein möglichst frühzeitiges und vor allem radikalchirurgisches Vorgehen sollte deshalb immer in Erwägung gezogen werden.

Abstract

Urothelium carcinomas with β HCG positive markers are a rarity in tumour differentiation. Syncytiotrophoblastic and, in a few cases, cytotrophoblastic giant cells are typical for this carcinoma. Such differentiation has an intensified potential for invasiveness and is accompanied by increased angiogenesis. In the present case, the mixture of trophoblastic cells indicates a common stem cell.

In comparison with β HCG negative transitional cell carcinoma, the prognosis is bad for β HCG positive carcinoma. For this reason, a radical operation should be taken into consideration as early as possible.

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Authors and Affiliations

  1. Urologische Abteilung, HELIOS-Klinik Blankenhain

    X. Krah, E. Klose, G. Atanassov, G. Eschholz & H. M. Weber

  2. Institut für Pathologie, HELIOS-Klinikum Erfurt

    H. Kosmehl

  3. Urologische Abteilung, HELIOS-Klinik Blankenhain, Wirthstr. 5, 99444 , Blankenhain

    X. Krah

Authors
  1. X. Krah
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  2. E. Klose
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  3. G. Atanassov
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  4. G. Eschholz
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  5. H. Kosmehl
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  6. H. M. Weber
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Correspondence to X. Krah.

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Krah, X., Klose, E., Atanassov, G. et al. Das Urothelkarzinom mit trophoblastischer Differenzierung. Urologe 45, 81–84 (2006). https://doi.org/10.1007/s00120-005-0953-y

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  • DOI: https://doi.org/10.1007/s00120-005-0953-y

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