Skip to main content

Postoperative Darmparalyse durch den Muscarinrezeptorenblocker Tiotropiumbromid

Postoperative intestinal paralysis caused by the muscarinic receptor blocker tiotropium bromide

Der Urologe, Ausgabe A volume 44, pages 393–395 (2005)Cite this article

Zusammenfassung

Die medikamentöse Beeinflussung der verschiedenen Muscarinrezeptoren gewinnt bei der Therapie unterschiedlicher Erkrankungen zunehmend Interesse. Obwohl das chemische Design der Arzneimittel immer spezifischer wird, sind Nebenwirkungen in anderen Organsystemen nicht völlig zu verhindern.

Nach den vorliegenden Beobachtungen kann der Bronchodilatator Tiotropiumbromid in geeigneten Situationen schwerwiegende Motilitätsstörungen des Intestinums verursachen.

Abstract

Drug-induced manipulation of the different muscarinic receptors is gaining increasing interest in the treatment of various diseases. Despite enhanced specific chemical design of these substances, side effects in other organ systems cannot be avoided completely.

The observations presented led to the conclusion that under certain circumstances the bronchodilator tiotropium bromide can cause paralytic ileus.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Literatur

  1. Schmidt RF, Thews G (1995) Physiologie des Menschen, 26 Aufl. Springer, Berlin Heidelberg New York, S 808

  2. Anderson KE, Schröder A (2004) Veränderungen der Muskarinrezeptoren der alternden Harnblase. Urologe A 43: 552–556

    Google Scholar 

  3. Barnes PJ, Belvisi MG, Mak JCW et al. (1995) The pharmacological properties of Tiotropium. Life Sci 52: 521-528

    Google Scholar 

  4. Disse B, Speck G, Rominger KL, Witek TJ Jr, Hammer R (1993) Tiotropiumbromide. Life Sci 52: 837–844

    Google Scholar 

  5. Casaburi R, Mahler DA, Jones PW et al. (2002) A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 19: 217–224

    Article  CAS  PubMed  Google Scholar 

  6. Willaert W, Daenen M, Bomans P, Verleden G, Decramer M (2002) Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Eur Respir J 19: 926–935

    Google Scholar 

Download references

Interessenkonflikt:

Keine Angaben

Author information

Affiliations

  1. Urologische Belegabteilung, Klinikum, Starnberg

    G. M. Praetorius

  2. Urologische Belegabteilung, Klinikum, Oswaldstraße 1, 82319, Starnberg

    G. M. Praetorius

Authors
  1. G. M. Praetorius
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. M. Praetorius.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Praetorius, G.M. Postoperative Darmparalyse durch den Muscarinrezeptorenblocker Tiotropiumbromid. Urologe [A] 44, 393–395 (2005). https://doi.org/10.1007/s00120-004-0749-5

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00120-004-0749-5

Schlüsselwörter

  • Tiotropiumbromid
  • Obstipation
  • Postoperativer paralytischer Ileus

Keywords

  • Tiotropium bromide
  • Obstipation
  • Postoperative paralytic ileus