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Genetic pathways and new progression markers for prostate cancer defined by microsatellite allelotyping

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Abstract

A prospective study was carried out on a large cohort of males undergoing radical retropubic prostatectomy in order to identify genetic marker regions significantly associated with tumor formation. By comprehensive allotyping of chromosomes known to be associated with prostate carcinogenesis, an algorithm could be formulated for the genetic pathway and a method of discrimination between aggressive and less aggressive forms could be identified.

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Abbreviations

AI-:

Allelic imbalance

CaP-:

Cancer of the prostate

LOH-:

Loss of heterozygosity

MSA-:

Microsatellite analysis

Rb-:

Retinoblastoma gene

References

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Acknowledgements

This study was funded in part by grant QLRT-2000–00602 from the 5th Framework Program of the European Union. The complete manuscript of this study has been published in Clinical Cancer Research 2004, 10:1064–1073

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Authors and Affiliations

  1. Department of Urology, Philipps-University Marburg Medical School, Germany

    Rolf von Knobloch, Lutz Konrad, Heidrun Brandt, Sebastian Wille, Axel Heidenreich & Rainer Hofmann

  2. Department of Pathology, Philipps-University Marburg Medical School, Germany

    Peter J. Barth & Roland Moll

  3. Department of Pathology, Philipps-University Marburg Medical School, Baldingerstrasse, 35043, Marburg/Lahn, Germany

    Rolf von Knobloch

Authors
  1. Rolf von Knobloch
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  2. Lutz Konrad
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  3. Peter J. Barth
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  4. Heidrun Brandt
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  5. Sebastian Wille
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  6. Axel Heidenreich
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  7. Roland Moll
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  8. Rainer Hofmann
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Corresponding author

Correspondence to Rolf von Knobloch.

Additional information

Summary of article published in Clin Cancer Res (2004) 10:1064–1073

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von Knobloch, R., Konrad, L., Barth, P.J. et al. Genetic pathways and new progression markers for prostate cancer defined by microsatellite allelotyping. Urologe 43 (Suppl 3), 149–152 (2004). https://doi.org/10.1007/s00120-004-0611-9

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  • DOI: https://doi.org/10.1007/s00120-004-0611-9

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