References
Motzer RJ, Bander NH, Nanus DM (1996) Renal-cell carcinoma. N Engl J Med 335:865–875
Schendel DJ, Oberneder R, Falk CS, Jantzer P, Kressenstein S, Maget B, Hofstetter A, Riethmüller G, Nößner, E (1997) Cellular and molecular analyses of MHC-restricted and non-MHC-restricted effector cells recognizing renal carcinomas: problems and perspectives for immunotherapy. J Mol Med 75:400–413
Schendel DJ, Gansbacher B, Oberneder R, Kriegmair M, Hofstetter A, Riethmüller G, Segurado OG (1993) Tumor-specific lysis of renal cell carcinomas by tumor-infiltrating lymphocytes. I. HLA-A2-restricted recognition of autologous and allogeneic tumor lines. J Immunol 151:4209–4220
Jantzer P, Schendel DJ (1998) Human renal cell carcinoma antigen-specific cytotoxic T lymphocytes: antigen-driven selection and long-term persistence in vivo. Cancer Res 58:3078–3086
Nößner E, Schendel DJ (1999) Autologous and allogeneic tumor cell vaccines. In Blankenstein T (ed) Gene therapy, principles and applications. Birkhäuser, Basel, pp 299–312
Schendel DJ, Gansbacher B (1993) Tumor-specific lysis of human renal cell carcinomas by tumor-infiltrating lymphocytes. II. Modulation of recognition through retroviral transduction of tumor cells with IL-2 cDNA and exogenous interferon-alpha treatment. Cancer Res 53:4020–4025
Schendel DJ, Frankenberger B, Jantzer P, Cayeux S, Nößner E, Willimsky G, Maget B, Pohla H, Blankenstein T (2000) Expression of B7.1 (CD80) in a renal cell carcinoma line allows expansion of tumor-associated cytotoxic T lymphocytes in the presence of an alloresponse. Gene Ther 7:2007–2014
Pohla H, Frankenberger B, Stadlbauer B, Oberneder R, Hofstetter A, Willimsky G, Pezzutto A, Dörken B, Blankenstein T, Schendel DJ (2000) Allogeneic vaccination for renal cell carcinoma: development and monitoring. Bone Marrow Transplant 25:83–87
Becker C, Pohla H, Frankenberger B, Assenmacher M, Schendel DJ, Blankenstein T (2001) Adoptive tumor therapy with T lymphocytes enriched through an IFNγ capture assay. Nature Med 7:1159–1162
Schleypen JS, von Geldern M, Weiß EH, Kotzias N, Rohrmann K, Schendel DJ, Falk CS, Pohla H (2003) Renal cell carcinoma infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I-allotype. Int J Cancer 106:905–912
Schendel DJ, Falk CS, Nößner E, Maget B, Kressenstein S, Urlinger S, Tampe’ R, Gansbacher B (2000) Gene transfer of human interferon gamma complementary DNA into renal cell carcinoma lines enhances MHC-restricted cytotoxic T lymphocyte recognition but suppresses non-MHC-restricted effector cell activity. Gene Ther 7:950–959
Falk CS, Noessner E, Weiss EH, Schendel DJ (2002) Retaliation against tumor cells showing aberrant HLA expression using lymphokine activated killer (LAK)-derived T cells. Cancer Res 62:480–487
Falk CS, Schendel DJ (2002) Allogeneic MHC class I ligands and their role in positive and negative regulation of human cytotoxic effector cells. Human Immunol 63:8–19
Noessner E, Falk CS, Schendel DJ (2003) Interferon alpha and gamma differentially alter the susceptibility of tumor cells to lysis by MHC-restricted and non-MHC-restricted cytotoxic effector cells. In Hiddemann W, Büchner T, Ritter J, Unterhalt M, Haferlach T (eds) Acute leukemias IX: basic research, experimental approaches and novel therapies. Springer, Berlin Heidelberg New York, pp 497–503
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Schendel, D.J., Falk, C.S., Frankenberger, B. et al. The cellular and molecular basis of natural antitumor immunity in renal cell carcinoma patients. Urologe 43 (Suppl 3), 133–135 (2004). https://doi.org/10.1007/s00120-004-0601-y
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DOI: https://doi.org/10.1007/s00120-004-0601-y