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„Magnetic particle imaging“

Von der Forschung zur klinischen Perspektive

Magnetic particle imaging

From research to the prospect of clinical use

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Zusammenfassung

Hintergrund

Die Magnet-Partikel-Bildgebung bietet ein weitreichendes Potenzial mit einzigartigem Anwendungsspektrum.

Fragestellung

Identifikation von Applikationsszenarien mit Mehrwert für den klinischen Einsatz.

Material und Methode

Übersicht bisheriger Anwendungsszenarien im Phantom- und Kleintiermodell, Evaluation des „dual-use potentials“.

Ergebnisse

Die Magnet-Partikel-Bildgebung bietet mit ihrem einzigartigen Anwendungsprofil eine Lösung für die klinische Anwendung, wo bisherige, etablierte Bildgebungsverfahren an ihre Grenzen geraten. Als Tracerbildgebung zeichnet sie sich besonders durch ihre hohe Geschwindigkeit, Sensitivität und durch ihr Kontrast-Rausch-Verhältnis aus. Durch die geringen Magnetfelder und den geringen Leistungsverbrauch lässt sich die Bildgebung mobil gestalten und an Orte bringen, die bisher nicht zugänglich waren.

Schlussfolgerung

Die Magnet-Partikel-Bildgebung hat in den letzten Jahren eine schnelle Entwicklung verzeichnet. Die im Kleintiermodell und im Phantom gezeigten Anwendungen konnten die Vielseitigkeit und den Mehrwert der Methode untermauern. Mit der Verfügbarkeit humaner Bildgebungssysteme muss sich die Technologie den klinischen Überprüfungsstudien stellen.

Abstract

Background

Magnetic particle imaging offers far-reaching potential with a unique range of applications.

Objectives

Identification of application scenarios with added value for clinical use.

Methods

Overview of previous application scenarios in phantom and small animal models, evaluation of dual-use potential.

Results

With its unique application profile, magnetic particle imaging offers a solution for clinical use where common, established imaging techniques reach their limits. As a tracer imaging technique, it is particularly characterized by its high speed, sensitivity and contrast-to-noise ratio. The low magnetic fields and low power consumption allow imaging to be mobile and taken to locations that were previously inaccessible.

Conclusion

Magnetic particle imaging has seen rapid development in recent years. The applications demonstrated in the small animal model and phantom were able to support the versatility and added value of the method. With the availability of human imaging systems, the technology must face clinical verification studies.

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Authors and Affiliations

  1. Fraunhofer Einrichtung für Individualisierte und Zellbasierte Medizintechnik, Mönkhofer Weg 239a, 23562, Lübeck, Deutschland

    Matthias Gräser, Jonas Schumacher, Mandy Ahlborg, Eric Aderhold, Pascal Stagge, Justin Ackers & Thorsten M. Buzug

  2. Institut für Medizintechnik, Universität zu Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland

    Matthias Gräser, Ksenija Gräfe, Yvonne Blancke Soares, Kerstin Lüdtke-Buzug, Alexander Neumann, Pascal Stagge, Huimin Wei & Thorsten M. Buzug

  3. Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland

    Franz Wegner

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  1. Matthias Gräser
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Correspondence to Matthias Gräser.

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Interessenkonflikt

M. Gräser, F. Wegner, J. Schumacher, M. Ahlborg, K. Gräfe, E. Aderhold, Y. Blancke Soares, K. Lüdtke-Buzug, A. Neumann, P. Stagge, H. Wei, J. Ackers und T.M. Buzug geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Gräser, M., Wegner, F., Schumacher, J. et al. „Magnetic particle imaging“. Radiologie 62, 496–503 (2022). https://doi.org/10.1007/s00117-022-01011-9

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