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Seltene Formen der entzündlichen Erkrankungen des Zentralnervensystems

Unusual forms of inflammatory diseases of the central nervous system

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Zusammenfassung

Hintergrund

Entzündlich bedingte Schäden der weißen Substanz sind häufige Befunde in der kranialen Magnetresonanztomographie (cMRT). Wenn die Bildmorphologie, Symptomatik und Laborwerte nicht den geläufigen Krankheitsbildern entsprechen, bilden sie die Grundlage interessanter aber auch manchmal emotional geführter Diskussionen.

Ziel

Während in einem vorherigen Artikel bereits die typischen Erkrankungen diskutiert wurden, wird im folgenden Beitrag auf ungewöhnliche Ursachen eingegangen. Dabei wird das Augenmerk auf charakteristische Unterscheidungsmerkmale gelegt, die dem Radiologen eine Zuordnung erleichtern sollen.

Abstract

Background

White matter lesions of the central nervous system (CNS) are frequently encountered on magnetic resonance imaging (MRI) exams. If the morphologic findings, clinical symptoms and laboratory results are not typical for one of the more common inflammatory CNS diseases, the diagnosis may become challenging, which also means that interesting and sometime emotional discussions may arise.

Objective

While frequent causes of inflammatory CNS diseases were already discussed in a previous article, we now focus on more seldom forms and place attention on morphologic characteristics which may help to find the correct diagnosis.

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Literatur

  1. Allmendinger AM, Spektor V, Destian S (2010) CT and MR imaging of Susac syndrome in a young male presenting with acute disorientation. Clin Imaging 34:138–142

    Article  Google Scholar 

  2. Allmendinger AM, Mallery RM, Magro CM et al (2014) Cauda equina involvement in Susac’s syndrome. J Neurol Sci 337:91–96

    Article  Google Scholar 

  3. Amnesty International (2017) Glossar Für Diskriminierungssensible Sprache. https://www.amnesty.de/2017/3/1/glossar-fuer-diskriminierungssensible-sprache

  4. Chang CS, Chen WL, Li CT et al (2009) Cavernous sinus syndrome due to sarcoidosis: a case report. Acta Neurol Taiwan 18:37–41

    PubMed  Google Scholar 

  5. Dorr J, Krautwald S, Wildemann B et al (2013) Characteristics of Susac syndrome: a review of all reported cases. Nat Rev Neurol 9:307–316

    Article  Google Scholar 

  6. Fritz D, van de Beek D, Brouwer MC (2016) Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis. BMC Neurol 16:220

    Article  Google Scholar 

  7. Jarius S, Kleffner I, Dorr JM et al (2014) Clinical, paraclinical and serological findings in Susac syndrome: an international multicenter study. J Neuroinflammation 11:46

    Article  Google Scholar 

  8. Kanno A, Masamune A, Okazaki K, Kamisawa T, Kawa S, Nishimori I, Tsuji I, Shimosegawa T (2015) Research committee of intractable disease of the pancreas.: nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2011. Pancreas 44:535–539

    Article  Google Scholar 

  9. Kim DH, Cho WH, Cho KS et al (2014) Solitary cavernous sinus neurosarcoidosis mimicking neurosyphilis. J Korean Neurosurg Soc 55:61–63

    Article  Google Scholar 

  10. Koga M, Kusunoki S, Kaida K et al (2012) Nationwide survey of patients in Japan with Bickerstaff brainstem encephalitis: epidemiological and clinical characteristics. J Neurol Neurosurg Psychiatry 83:1210–1215

    Article  Google Scholar 

  11. Le Hua H, Donlon SL, Okuda DT (2014) A case of Susac syndrome with cervical spinal cord involvement on MRI. J Neurol Sci 337:228–231

    Article  Google Scholar 

  12. Lu Z, Tongxi L, Jie L et al (2016) IgG4-related spinal pachymeningitis. Clin Rheumatol 35:1549–1553

    Article  Google Scholar 

  13. Marlin ES, Dornbos D 3rd, Ikeda DS et al (2017) IgG4-related disease: a new etiology underlying diffuse Intracranial dilating vasculopathy. World Neurosurg 107:1048.e15–1048.e20

    Article  Google Scholar 

  14. Nagaoka U, Kato T, Kurita K et al (1996) Cranial nerve enhancement on three-dimensional MRI in Miller Fisher syndrome. Neurology 47:1601–1602

    Article  CAS  Google Scholar 

  15. Odaka M, Yuki N, Yamada M et al (2003) Bickerstaff’s brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barre syndrome. Brain 126:2279–2290

    Article  Google Scholar 

  16. Rennebohm R, Susac JO, Egan RA et al (2010) Susac’s syndrome—update. J Neurol Sci 299:86–91

    Article  Google Scholar 

  17. Segal BM (2013) Neurosarcoidosis: diagnostic approaches and therapeutic strategies. Curr Opin Neurol 26:307–313

    Article  CAS  Google Scholar 

  18. Seghers A, Van Calster J, Wilms G et al (2015) Characteristic callosal involvement in Susac’s syndrome. Acta Neurol Belg 115:395–396

    Article  Google Scholar 

  19. Sohn M, Culver DA, Judson MA et al (2014) Spinal cord neurosarcoidosis. Am J Med Sci 347:195–198

    Article  Google Scholar 

  20. Storti B, Vedovello M, Riva R et al (2020) Posterior reversible encephalopathy and Guillain-Barre syndrome: which came first, the chicken or the egg? A review of literature. Neurol Sci 41:3663–3666

    Article  Google Scholar 

  21. Susac JO, Hardman JM, Selhorst JB (1979) Microangiopathy of the brain and retina. Neurology 29:313–316

    Article  CAS  Google Scholar 

  22. Susac JO, Murtagh FR, Egan RA et al (2003) MRI findings in Susac’s syndrome. Neurology 61:1783–1787

    Article  CAS  Google Scholar 

  23. Susac JO, Egan RA, Rennebohm RM et al (2007) Susac’s syndrome: 1975–2005 microangiopathy/autoimmune endotheliopathy. J Neurol Sci 257:270–272

    Article  Google Scholar 

  24. Tezer FI, Gurer G, Karatas H et al (2002) Involvement of the central nervous system in Miller Fisher syndrome: a case report. Clin Neurol Neurosurg 104:377–379

    Article  Google Scholar 

  25. Toyoda K, Oba H, Kutomi K et al (2012) MR imaging of IgG4-related disease in the head and neck and brain. AJNR Am J Neuroradiol 33:2136–2139

    Article  CAS  Google Scholar 

  26. Tsappidi S, Hui F, Turan TN et al (2011) Intracerebral hemorrhage: an unusual presentation of neurosarcoidosis. Neurologist 17:292–296

    Article  Google Scholar 

  27. Valeyre D, Prasse A, Nunes H et al (2014) Sarcoidosis. Lancet 383:1155–1167

    Article  Google Scholar 

  28. Valmaggia C, Speiser P, Bischoff P et al (1999) Indocyanine green versus fluorescein angiography in the differential diagnosis of arteritic and nonarteritic anterior ischemic optic neuropathy. Retina 19:131–134

    Article  CAS  Google Scholar 

  29. Wallace ZS, Deshpande V, Stone JH (2014) Ophthalmic manifestations of IgG4-related disease: single-center experience and literature review. Semin Arthritis Rheum 43:806–817

    Article  CAS  Google Scholar 

  30. Weidauer S, Ziemann U, Thomalske C et al (2003) Vasogenic edema in Bickerstaff’s brainstem encephalitis: a serial MRI study. Neurology 61:836–838

    Article  CAS  Google Scholar 

  31. Zuccoli G, Panigrahy A, Bailey A et al (2011) Redefining the Guillain-Barre spectrum in children: neuroimaging findings of cranial nerve involvement. AJNR Am J Neuroradiol 32:639–642

    Article  CAS  Google Scholar 

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Correspondence to Armin Bachhuber.

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A. Bachhuber gibt an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden vom Autor keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Bachhuber, A. Seltene Formen der entzündlichen Erkrankungen des Zentralnervensystems. Radiologe 62, 302–307 (2022). https://doi.org/10.1007/s00117-022-00983-y

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