Zusammenfassung
Hintergrund
Entzündlich bedingte Schäden der weißen Substanz sind häufige Befunde in der kranialen Magnetresonanztomographie (cMRT). Wenn die Bildmorphologie, Symptomatik und Laborwerte nicht den geläufigen Krankheitsbildern entsprechen, bilden sie die Grundlage interessanter aber auch manchmal emotional geführter Diskussionen.
Ziel
Während in einem vorherigen Artikel bereits die typischen Erkrankungen diskutiert wurden, wird im folgenden Beitrag auf ungewöhnliche Ursachen eingegangen. Dabei wird das Augenmerk auf charakteristische Unterscheidungsmerkmale gelegt, die dem Radiologen eine Zuordnung erleichtern sollen.
Abstract
Background
White matter lesions of the central nervous system (CNS) are frequently encountered on magnetic resonance imaging (MRI) exams. If the morphologic findings, clinical symptoms and laboratory results are not typical for one of the more common inflammatory CNS diseases, the diagnosis may become challenging, which also means that interesting and sometime emotional discussions may arise.
Objective
While frequent causes of inflammatory CNS diseases were already discussed in a previous article, we now focus on more seldom forms and place attention on morphologic characteristics which may help to find the correct diagnosis.
Literatur
Allmendinger AM, Spektor V, Destian S (2010) CT and MR imaging of Susac syndrome in a young male presenting with acute disorientation. Clin Imaging 34:138–142
Allmendinger AM, Mallery RM, Magro CM et al (2014) Cauda equina involvement in Susac’s syndrome. J Neurol Sci 337:91–96
Amnesty International (2017) Glossar Für Diskriminierungssensible Sprache. https://www.amnesty.de/2017/3/1/glossar-fuer-diskriminierungssensible-sprache
Chang CS, Chen WL, Li CT et al (2009) Cavernous sinus syndrome due to sarcoidosis: a case report. Acta Neurol Taiwan 18:37–41
Dorr J, Krautwald S, Wildemann B et al (2013) Characteristics of Susac syndrome: a review of all reported cases. Nat Rev Neurol 9:307–316
Fritz D, van de Beek D, Brouwer MC (2016) Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis. BMC Neurol 16:220
Jarius S, Kleffner I, Dorr JM et al (2014) Clinical, paraclinical and serological findings in Susac syndrome: an international multicenter study. J Neuroinflammation 11:46
Kanno A, Masamune A, Okazaki K, Kamisawa T, Kawa S, Nishimori I, Tsuji I, Shimosegawa T (2015) Research committee of intractable disease of the pancreas.: nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2011. Pancreas 44:535–539
Kim DH, Cho WH, Cho KS et al (2014) Solitary cavernous sinus neurosarcoidosis mimicking neurosyphilis. J Korean Neurosurg Soc 55:61–63
Koga M, Kusunoki S, Kaida K et al (2012) Nationwide survey of patients in Japan with Bickerstaff brainstem encephalitis: epidemiological and clinical characteristics. J Neurol Neurosurg Psychiatry 83:1210–1215
Le Hua H, Donlon SL, Okuda DT (2014) A case of Susac syndrome with cervical spinal cord involvement on MRI. J Neurol Sci 337:228–231
Lu Z, Tongxi L, Jie L et al (2016) IgG4-related spinal pachymeningitis. Clin Rheumatol 35:1549–1553
Marlin ES, Dornbos D 3rd, Ikeda DS et al (2017) IgG4-related disease: a new etiology underlying diffuse Intracranial dilating vasculopathy. World Neurosurg 107:1048.e15–1048.e20
Nagaoka U, Kato T, Kurita K et al (1996) Cranial nerve enhancement on three-dimensional MRI in Miller Fisher syndrome. Neurology 47:1601–1602
Odaka M, Yuki N, Yamada M et al (2003) Bickerstaff’s brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barre syndrome. Brain 126:2279–2290
Rennebohm R, Susac JO, Egan RA et al (2010) Susac’s syndrome—update. J Neurol Sci 299:86–91
Segal BM (2013) Neurosarcoidosis: diagnostic approaches and therapeutic strategies. Curr Opin Neurol 26:307–313
Seghers A, Van Calster J, Wilms G et al (2015) Characteristic callosal involvement in Susac’s syndrome. Acta Neurol Belg 115:395–396
Sohn M, Culver DA, Judson MA et al (2014) Spinal cord neurosarcoidosis. Am J Med Sci 347:195–198
Storti B, Vedovello M, Riva R et al (2020) Posterior reversible encephalopathy and Guillain-Barre syndrome: which came first, the chicken or the egg? A review of literature. Neurol Sci 41:3663–3666
Susac JO, Hardman JM, Selhorst JB (1979) Microangiopathy of the brain and retina. Neurology 29:313–316
Susac JO, Murtagh FR, Egan RA et al (2003) MRI findings in Susac’s syndrome. Neurology 61:1783–1787
Susac JO, Egan RA, Rennebohm RM et al (2007) Susac’s syndrome: 1975–2005 microangiopathy/autoimmune endotheliopathy. J Neurol Sci 257:270–272
Tezer FI, Gurer G, Karatas H et al (2002) Involvement of the central nervous system in Miller Fisher syndrome: a case report. Clin Neurol Neurosurg 104:377–379
Toyoda K, Oba H, Kutomi K et al (2012) MR imaging of IgG4-related disease in the head and neck and brain. AJNR Am J Neuroradiol 33:2136–2139
Tsappidi S, Hui F, Turan TN et al (2011) Intracerebral hemorrhage: an unusual presentation of neurosarcoidosis. Neurologist 17:292–296
Valeyre D, Prasse A, Nunes H et al (2014) Sarcoidosis. Lancet 383:1155–1167
Valmaggia C, Speiser P, Bischoff P et al (1999) Indocyanine green versus fluorescein angiography in the differential diagnosis of arteritic and nonarteritic anterior ischemic optic neuropathy. Retina 19:131–134
Wallace ZS, Deshpande V, Stone JH (2014) Ophthalmic manifestations of IgG4-related disease: single-center experience and literature review. Semin Arthritis Rheum 43:806–817
Weidauer S, Ziemann U, Thomalske C et al (2003) Vasogenic edema in Bickerstaff’s brainstem encephalitis: a serial MRI study. Neurology 61:836–838
Zuccoli G, Panigrahy A, Bailey A et al (2011) Redefining the Guillain-Barre spectrum in children: neuroimaging findings of cranial nerve involvement. AJNR Am J Neuroradiol 32:639–642
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
A. Bachhuber gibt an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden vom Autor keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
Additional information
QR-Code scannen & Beitrag online lesen
Rights and permissions
About this article
Cite this article
Bachhuber, A. Seltene Formen der entzündlichen Erkrankungen des Zentralnervensystems. Radiologe 62, 302–307 (2022). https://doi.org/10.1007/s00117-022-00983-y
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00117-022-00983-y
Schlüsselwörter
- Neurosarkoidose
- Susac-Syndrom
- IgG4-assoziierte Erkrankungen
- Miller Fisher-Syndrom
- Kraniale Magnetresonanztomographie