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Neuerungen der WHO‑Klassifikation der Hirntumore von 2016

Alterations in the WHO classification of brain tumors from 2016

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Zusammenfassung

Hintergrund

Die Weltgesundheitsorganisation erstellt einheitliche Definitionen und Klassifikationen von Tumoren der verschiedenen Organsysteme.

Fragestellung

Welche Änderungen ergeben sich aus der Fortschreibung der Klassifikation der Hirntumore von 2016?

Material und Methoden

Darstellung der Veränderungen bei Definition und Klassifikation der Hirntumoren in der aktuellen Fortschreibung der WHO, die sich insbesondere durch molekularpathologische Erkenntnisse der letzten Jahre ergeben.

Ergebnisse

Die aktuelle WHO-Klassifikation der Hirntumore basiert erstmals nicht mehr ausschließlich auf histologischen Charakteristika, sondern bezieht molekularpathologische Informationen in Diagnose und Klassifikation etlicher Hirntumore mit ein. Dieses gilt insbesondere für gliale Tumore, Medulloblastome und weitere embryonale Tumore.

Schlussfolgerung

Definition und Klassifikation der Hirntumore entwickeln sich in Richtung einer modularen Diagnostik, bei der histologische und molekularpathologische Informationen in eine Gesamtbewertung einfließen. Ziel ist es, dadurch zu einheitlicheren Diagnosegruppen hinsichtlich Prognose und Therapie zu kommen.

Abstract

Background

The World Health Organization (WHO) provides uniform definitions and a uniform nomenclature for tumors of various organs.

Objective

What changes resulted from the 2016 WHO classification of tumors of the central nervous system?

Material and methods

Changes in the definition and classification of brain tumors of the revised WHO classification are presented. Most changes evolve from the results of molecular pathology that were generated during the last decade.

Results

For the first time the WHO classification of brain tumors is not based exclusively on histology. Molecular parameters add to the definition of a number of tumor entities. Especially the chapters of gliomas, medulloblastomas and other embryonal tumors have been restructured.

Conclusion

Advances in molecular pathology require a modular diagnostics scheme that integrates histological and molecular parameters into a final diagnosis. This approach will result in more precise tumor groups with respect to prognosis and therapy.

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Authors and Affiliations

  1. Institut für Neuropathologie, Universitätsklinikum des Saarlandes, Kirrberger Strasse 100, Gebäude 90.3, 66421, Homburg/Saar, Deutschland

    W. J. Schulz-Schaeffer

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  1. W. J. Schulz-Schaeffer
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Correspondence to W. J. Schulz-Schaeffer.

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W. J. Schulz-Schaeffer gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Schulz-Schaeffer, W.J. Neuerungen der WHO‑Klassifikation der Hirntumore von 2016. Radiologe 57, 701–706 (2017). https://doi.org/10.1007/s00117-017-0290-3

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  • DOI: https://doi.org/10.1007/s00117-017-0290-3

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