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Interventionelle Therapie der benignen Prostatahyperplasie

Embolisation der V. spermatica

Interventional treatment of benign prostatic hyperplasia

Embolization of the testicular vein

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Zusammenfassung

Klinisches/methodisches Problem

Als interventionelles Verfahren zur Behandlung der benignen Prostatahyperplasie (BPH) wird die Embolisation der Vv. spermaticae (Gat-Goren-Technik) diskutiert.

Radiologische Standardverfahren

Neben urologischen Standardeingriffen wie z. B. der transurethralen Prostataresektion (TUR-P) gilt die arterielle Embolisation der Prostata bisher als interventionell-radiologisches Verfahren der Wahl.

Methodische Innovationen

Die Embolisation der Vv. spermaticae entspricht technisch einer Varikozelenembolisation bei infertilen Männern und stellt eine wenig invasive Behandlungsmethode dar.

Leistungsfähigkeit

Die Embolisation kann als risiko- und nebenwirkungsarmes Verfahren durchgeführt werden. Varianten der venösen Anatomie können den Eingriff erschweren. In aktuellen Studien wird im mittelfristigen Verlauf von einer guten Symptomreduktion berichtet.

Bewertung

Obwohl mittelfristige Ergebnisse vielversprechend sind, fehlen bisher Daten zu Langzeitergebnissen und Vergleiche zu alternativen Behandlungsmethoden.

Empfehlung für die Praxis

Die Embolisation der Vv. spermaticae zur Behandlung der BPH stellt eine wenig invasive Methode dar. Der Eingriff kann ambulant oder tagesstationär durchgeführt werden. Im mittelfristigen Verlauf bis 6 Monate nach dem Eingriff zeigen sich in bisher durchgeführten Untersuchungen zufriedenstellende Ergebnisse. Randomisierte Studien, Daten zu Langzeitergebnissen und Vergleiche zu alternativen Methoden (z. B. arterielle Prostataembolisation, operative Verfahren) fehlen bisher.

Abstract

Clinical/methodical issue

Embolization of the testicular veins (Gat-Goren technique) is an interventional procedure for the treatment of benign prostatic hyperplasia (BPH).

Standard radiological methods

In addition to standard urological procedures, such as transurethral resection of the prostate (TUR-P), arterial embolization of the prostate is considered as the interventional radiological method of choice.

Methodical innovations

Embolization of the testicular veins is technically identical to the embolization of varicoceles in infertile men and represents a less invasive treatment.

Performance

Embolization of the testicular veins can be performed as a low-risk intervention with low side effects. Variants of the venous anatomy can make the procedure more difficult. In current studies a good reduction of symptoms could be achieved in intermediate-term follow-up.

Achievements

The medium-term results are promising but data on long-term results and comparisons with alternative treatments are missing.

Practical recommendations

Embolization of the testicular veins is a minimally invasive method for the treatment of BPH. The procedure can be performed in an outpatient setting. In the intermediate course up to 6 months after treatment, promising results were demonstrated in recent studies. Randomized studies, data on long-term results and comparisons to alternative methods (e. g. arterial prostatic embolization and surgical procedures) are missing.

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Literatur

  1. Bahren W, Lenz M, Porst H et al (1983) Nebenwirkungen, Komplikationen und Kontraindikationen der perkutanen Sklerotherapie der V. spermatica interna zur Behandlung der idiopathischen Varikozele. Rofo 138:172–179

    Article  CAS  PubMed  Google Scholar 

  2. Bass JE, Redwine MD, Kramer LA et al (2000) Spectrum of congenital anomalies of the inferior vena cava: cross-sectional imaging findings. Radiographics 20:639–652

    Article  CAS  PubMed  Google Scholar 

  3. Bittles MA, Hoffer EK (2008) Gonadal vein embolization: treatment of varicocele and pelvic congestion syndrome. Semin Intervent Radiol 25:261–270

    Article  PubMed  PubMed Central  Google Scholar 

  4. Boyer L, Ravel A, Guy L et al (2014) Embolization of Varicoceles. In: Chabrot P, Boyer L (Hrsg) Embolization. Springer, London

    Google Scholar 

  5. Canales BK, Zapzalka DM, Ercole CJ et al (2005) Prevalence and effect of varicoceles in an elderly population. Urology 66:627–631

    Article  PubMed  Google Scholar 

  6. Caro JJ, Trindade E, Mcgregor M (1991) The risks of death and of severe nonfatal reactions with high- vs low-osmolality contrast media: a meta-analysis. AJR Am J Roentgenol 156:825–832

    Article  CAS  PubMed  Google Scholar 

  7. Cassidy D, Jarvi K, Grober E et al (2012) Varicocele surgery or embolization: Which is better? Can Urol Assoc J 6:266–268

    Article  PubMed  PubMed Central  Google Scholar 

  8. Cayan S, Kadioglu A, Orhan I et al (1999) The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele. BJU Int 84:1046–1049

    Article  CAS  PubMed  Google Scholar 

  9. Chatterjee B (2003) The role of the androgen receptor in the development of prostatic hyperplasia and prostate cancer. Mol Cell Biochem 253:89–101

    Article  CAS  PubMed  Google Scholar 

  10. Chomyn JJ, Craven WM, Groves BM et al (1991) Percutaneous removal of a Gianturco coil from the pulmonary artery with use of flexible intravascular forceps. J Vasc Interv Radiol 2:105–106

    Article  CAS  PubMed  Google Scholar 

  11. De Caestecker K, Lumen N, Spinoit AF et al (2016) Varicocele: the origin of benign prostatic hypertrophy? Testosterone dosages in the periprostatic plexus. Acta Clin Belg 71:281–283

    Article  Google Scholar 

  12. Edwards JE, Moore RA (2002) Finasteride in the treatment of clinical benign prostatic hyperplasia: a systematic review of randomised trials. BMC Urol 2:14

    Article  PubMed  PubMed Central  Google Scholar 

  13. Formanek A, Rusnak B, Zollikofer C et al (1981) Embolization of the spermatic vein for treatment of infertility: a new approach. Radiology 139:315–321

    Article  CAS  PubMed  Google Scholar 

  14. Gat Y, Gornish M, Heiblum M et al (2008) Reversal of benign prostate hyperplasia by selective occlusion of impaired venous drainage in the male reproductive system: novel mechanism, new treatment. Andrologia 40:273–281

    Article  CAS  PubMed  Google Scholar 

  15. Halpern J, Mittal S, Pereira K et al (2016) Percutaneous embolization of varicocele: technique, indications, relative contraindications, and complications. Asian J Androl 18:234–238

    Article  PubMed  Google Scholar 

  16. Han H, Yu ZX, Gong LH et al (2016) The prevalence and association of varicoceles on male patients with benign prostatic Hyperplasia/lower urinary tract symptoms. Urology 90:97–100

    Article  PubMed  Google Scholar 

  17. Hsiao W, Rosoff JS, Pale JR et al (2013) Varicocelectomy is associated with increases in serum testosterone independent of clinical grade. Urology 81:1213–1217

    Article  PubMed  Google Scholar 

  18. Iaccarino V, Venetucci P (2012) Interventional radiology of male varicocele: current status. Cardiovasc Intervent Radiol 35:1263–1280

    Article  PubMed  Google Scholar 

  19. Kim TB, Chang JH, Yoon SJ et al (2012) Hydrodynamic relationship between color Doppler ultrasonography findings and the number of internal spermatic veins in varicoceles. Yonsei Med J 53:386–392

    Article  PubMed  PubMed Central  Google Scholar 

  20. Lagiou P, Mantzoros CS, Tzonou A et al (1997) Serum steroids in relation to benign prostatic hyperplasia. Oncology 54:497–501

    Article  CAS  PubMed  Google Scholar 

  21. Lenz M, Hof N, Kersting-Sommerhoff B et al (1996) Anatomic variants of the spermatic vein: importance for percutaneous sclerotherapy of idiopathic varicocele. Radiology 198:425–431

    Article  CAS  PubMed  Google Scholar 

  22. Levinger U, Gornish M, Gat Y et al (2007) Is varicocele prevalence increasing with age? Andrologia 39:77–80

    Article  CAS  PubMed  Google Scholar 

  23. Monti S, Di Silverio F, Toscano V et al (1998) Androgen concentrations and their receptors in the periurethral region are higher than those of the subcapsular zone in benign prostatic hyperplasia (BPH). J Androl 19:428–433

    CAS  PubMed  Google Scholar 

  24. Otunctemur A, Ozbek E, Besiroglu H et al (2014) Is the presence of varicocele associated with static and dynamic components of benign prostatic hyperplasia/lower urinary tract symptoms in elderly men? Int J Urol 21:1268–1272

    Article  PubMed  Google Scholar 

  25. Sakamoto H, Ogawa Y (2008) Is varicocele associated with underlying venous abnormalities? Varicocele and the prostatic venous plexus. J Urol 180:1427–1431

    Article  PubMed  Google Scholar 

  26. Strunk H, Meier M, Schild HH et al (2015) Treatment of benign prostatic hyperplasia by occlusion of the impaired urogenital venous system – first experience. Rofo 187:180–186

    Article  CAS  PubMed  Google Scholar 

  27. Sze DY, Kao JS, Frisoli JK et al (2008) Persistent and recurrent postsurgical varicoceles: venographic anatomy and treatment with N‑butyl cyanoacrylate embolization. J Vasc Interv Radiol 19:539–545

    Article  PubMed  Google Scholar 

  28. Tanrikut C, Mcquaid JW, Goldstein M (2011) The impact of varicocele and varicocele repair on serum testosterone. Curr Opin Obstet Gynecol 23:227–231

    Article  PubMed  Google Scholar 

  29. Valji K (2012) Endocrine, exocrine, and reproductive systems. In: Valji K (Hrsg) The practice of Interventional radiology. Saunders, Philadelphia

    Google Scholar 

  30. Wunsch R, Efinger K (2005) The interventional therapy of varicoceles amongst children, adolescents and young men. Eur J Radiol 53:46–56

    Article  CAS  PubMed  Google Scholar 

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Correspondence to M. Rauch.

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Interessenkonflikt

M. Rauch und H. Strunk geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Rauch, M., Strunk, H. Interventionelle Therapie der benignen Prostatahyperplasie. Radiologe 57, 652–658 (2017). https://doi.org/10.1007/s00117-017-0275-2

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