Skip to main content
Log in

Neuere Entwicklungen der Leber-MRT

New developments in MRI of the liver

  • Leitthema
  • Published:
Der Radiologe Aims and scope Submit manuscript

Zusammenfassung

Das Fach Radiologie hat in der Medizin eine Sonderstellung erlangt. Eine exakte Diagnose ist entscheidend, um rasch und effizient behandeln zu können. Dies wirkt sich direkt auf den einzelnen Patienten aus, was mit einer Verkürzung der Zeit bis zur Diagnosestellung, dem Vermeiden unnötiger invasiver Methoden oder teuren zeitaufwendigen Verlaufskontrollen einhergeht. Die MRT stellt aufgrund ihrer kontinuierlichen Entwicklungen der letzten Jahre ein Musterbeispiel dar, v. a. bei der Diagnostik der verschiedenen Lebererkrankungen. In diesem Artikel erläutern wir den direkten Zusammenhang zwischen neueren technischen Entwicklungen im Bereich der MRT wie 3,0 T, diffusionsgewichteten Sequenzen, Perfusions-MRT, Spektroskopie, Texturanalyse sowie MR-Elastographie und dem Stellen einer sicheren, nichtinvasiven Diagnose der fokalen und diffusen Leberveränderungen.

Abstract

Radiology has gained an exceptional position in medicine because a correct diagnosis is the most crucial issue in determining an accurate and personalized therapeutic strategy. This has a direct influence not only on the individual patient but also on the socio-economic aspects of healthcare services in terms of shortening the time interval to establish a diagnosis and to avoid risk-associated invasive diagnostic methods or long-term, cost-intensive follow-up. Magnetic resonance imaging (MRI) is an excellent example of this which due to continuous technological developments and emerging techniques allows a non-invasive diagnosis of the different hepatic diseases. In this article, we illustrate the direct correlation between the recent technical advances in MRI, such as 3.0 T, diffusion-weighted imaging, perfusion imaging, spectroscopy, texture analysis and MR elastography and obtaining a confident non-invasive diagnosis of focal and diffuse liver diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Annet L, Peeters F, Abarca-Quinones J et al (2007) Assessment of diffusion-weighted MR imaging in liver fibrosis. J Magn Reson Imaging 25:122–128

    Article  PubMed  Google Scholar 

  2. Ba-Ssalamah A, Happel B, Kettenbach J et al (2004) MRT of the liver. Clinical significance of nonspecific and liver-specific MRT contrast agents. Radiologe 44:1170–1184

    Article  PubMed  CAS  Google Scholar 

  3. Ba-Ssalamah A, Uffmann M, Saini S et al (2009) Clinical value of MRI liver-specific contrast agents: a tailored examination for a confident non-invasive diagnosis of focal liver lesions. Eur Radiol 19:342–357

    Article  PubMed  Google Scholar 

  4. Barth MM, Smith MP, Pedrosa I et al (2007) Body MR imaging at 3.0 T: understanding the opportunities and challenges. Radiographics 27:1445–1462; discussion 1462–1444

    Article  PubMed  Google Scholar 

  5. Chang KJ, Kamel IR, Macura KJ et al (2008) 3.0-T MR imaging of the abdomen: comparison with 1.5 T. Radiographics 28:1983–1998

    Article  PubMed  Google Scholar 

  6. Chernyak V, Kim J, Rozenblit AM et al (2011) Hepatic enhancement during the hepatobiliary phase after gadoxetate disodium administration in patients with chronic liver disease: the role of laboratory factors. J Magn Reson Imaging. DOI 10.1002/jmri.22635

  7. Choe KA, Smith RC, Wilkens K et al (1997) Motion artifact in T2-weighted fast spin-echo images of the liver: effect on image contrast and reduction of artifact using respiratory triggering in normal volunteers. J Magn Reson Imaging 7:298–302

    Article  PubMed  CAS  Google Scholar 

  8. Choi JY, Choi JS, Kim MJ et al (2010) Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent. J Magn Reson Imaging 31:571–578

    Article  PubMed  Google Scholar 

  9. De Bazelaire CM, Duhamel GD, Rofsky NM et al (2004) MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 230:652–659

    Article  Google Scholar 

  10. Faria SC, Ganesan K, Mwangi I et al (2009) MR imaging of liver fibrosis: current state of the art. Radiographics 29:1615–1635

    Article  PubMed  Google Scholar 

  11. Fischbach F, Bruhn H (2008) Assessment of in vivo 1H magnetic resonance spectroscopy in the liver: a review. Liver Int 28:297–307

    Article  PubMed  CAS  Google Scholar 

  12. Fischbach F, Thormann M, Ricke J (2004) (1) H magnetic resonance spectroscopy (MRS) of the liver and hepatic malignant tumors at 3.0 Tesla. Radiologe 44:1192–1196

    Article  PubMed  CAS  Google Scholar 

  13. Fruehwald-Pallamar J, Bastati-Huber N, Fakhrai N et al (2011) Confident non-invasive diagnosis of pseudolesions of the liver using diffusion-weighted imaging at 3T MRI. Eur J Radiol, in press

  14. Hagiwara M, Rusinek H, Lee VS et al (2008) Advanced liver fibrosis: diagnosis with 3D whole-liver perfusion MR imaging – initial experience. Radiology 246:926–934

    Article  PubMed  Google Scholar 

  15. Holzapfel K, Breitwieser C, Prinz C et al (2007) Contrast-enhanced magnetic resonance cholangiography using gadolinium-EOB-DTPA. Preliminary experience and clinical applications. Radiologe 47:536–544

    Article  PubMed  CAS  Google Scholar 

  16. Huwart L, Sempoux C, Salameh N et al (2007) Liver fibrosis: noninvasive assessment with MR elastography versus aspartate aminotransferase-to-platelet ratio index. Radiology 245:458–466

    Article  PubMed  Google Scholar 

  17. Kim KA, Herigault G, Kim MJ et al (2011) Three-dimensional contrast-enhanced hepatic MR imaging: comparison between a centric technique and a linear approach with partial Fourier along both slice and phase directions. J Magn Reson Imaging 33:160–166

    Article  PubMed  Google Scholar 

  18. Kitao A, Zen Y, Matsui O et al (2010) Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR Imaging – correlation with molecular transporters and histopathologic features. Radiology 256:817–826

    Article  PubMed  Google Scholar 

  19. Mayerhoefer ME, Schima W, Trattnig S et al (2010) Texture-based classification of focal liver lesions on MRI at 3.0 Tesla: a feasibility study in cysts and hemangiomas. J Magn Reson Imaging 32:352–359

    Article  PubMed  Google Scholar 

  20. Merkle EM, Dale BM (2006) Abdominal MRI at 3.0 T: the basics revisited. AJR Am J Roentgenol 186:1524–1532

    Article  PubMed  Google Scholar 

  21. Mullins PG, Chen H, Xu J et al (2008) Comparative reliability of proton spectroscopy techniques designed to improve detection of J-coupled metabolites. Magn Reson Med 60:964–969

    Article  PubMed  CAS  Google Scholar 

  22. Nilsson H, Nordell A, Vargas R et al (2009) Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte-specific contrast-enhanced MRI. J Magn Reson Imaging 29:1323–1331

    Article  PubMed  Google Scholar 

  23. Pagani E, Bizzi A, Di Salle F et al (2008) Basic concepts of advanced MRI techniques. Neurol Sci 29(Suppl 3):290–295

    Article  PubMed  Google Scholar 

  24. Qayyum A (2009) MR spectroscopy of the liver: principles and clinical applications. Radiographics 29:1653–1664

    Article  PubMed  Google Scholar 

  25. Salameh N, Peeters F, Sinkus R et al (2007) Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat. J Magn Reson Imaging 26:956–962

    Article  PubMed  Google Scholar 

  26. Schmid-Tannwald C, Reiser MF, Zech CJ (2011) Diffusion-weighted magnetic resonance imaging of the abdomen. Radiologe 51:195–204

    Article  PubMed  CAS  Google Scholar 

  27. Seo HJ, Kim MJ, Lee JD et al (2011) Gadoxetate disodium-enhanced magnetic resonance imaging versus contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of colorectal liver metastases. Invest Radiol, in press

  28. Tamrazi A, Vasanawala SS (2011) Functional hepatobiliary MR imaging in children. Pediatr Radiol, in press

  29. Taouli B, Koh DM (2010) Diffusion-weighted MR imaging of the liver. Radiology 254:47–66

    Article  PubMed  Google Scholar 

  30. Tschirch FT, Struwe A, Petrowsky H et al (2008) Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma. Eur Radiol 18:1577–1586

    Article  PubMed  Google Scholar 

  31. Tsuda N, Okada M, Murakami T (2010) New proposal for the staging of nonalcoholic steatohepatitis: evaluation of liver fibrosis on Gd-EOB-DTPA-enhanced MRI. Eur J Radiol 73:137–142

    Article  PubMed  Google Scholar 

  32. Wang Y, Al Kasab TK, Narin O et al (2011) Incidence of nephrogenic systemic fibrosis after adoption of restrictive gadolinium-based contrast agent guidelines. Radiology, in press

  33. Watanabe H, Kanematsu M, Goshima S et al (2011) Staging hepatic fibrosis: comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging – preliminary observations. Radiology 259:142–150

    Article  PubMed  Google Scholar 

  34. Yopp AC, Schwartz LH, Kemeny N et al (2011) Antiangiogenic therapy for primary liver cancer: correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response. Ann Surg Oncol, in press

  35. Zech CJ, Herrmann KA, Dietrich O et al (2008) Black-blood diffusion-weighted EPI acquisition of the liver with parallel imaging: comparison with a standard T2-weighted sequence for detection of focal liver lesions. Invest Radiol 43:261–266

    Article  PubMed  Google Scholar 

  36. Zech CJ, Herrmann KA, Huber A et al (2004) High-resolution MR-imaging of the liver with T2-weighted sequences using integrated parallel imaging: comparison of prospective motion correction and respiratory triggering. J Magn Reson Imaging 20:443–450

    Article  PubMed  Google Scholar 

  37. Zech CJ, Schoenberg SO, Herrmann KA et al (2004) Modern visualization of the liver with MRT. Current trends and future perspectives. Radiologe 44:1160–1169

    Article  PubMed  CAS  Google Scholar 

  38. Zho SY, Park J, Choi JY et al (2010) Respiratory motion compensated MR cholangiopancreatography at 3.0 Tesla. J Magn Reson Imaging 32:726–732

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Die korrespondierende Autorin gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to N. Bastati-Huber MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bastati-Huber, N., Prosch, H., Baroud, S. et al. Neuere Entwicklungen der Leber-MRT. Radiologe 51, 680–687 (2011). https://doi.org/10.1007/s00117-010-2126-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00117-010-2126-2

Schlüsselwörter

Keywords

Navigation