Zusammenfassung
Mit neuen Schallkopftechnologien hat sich die Abbildungsqualität von Gefäßen im B-Mode deutlich verbessert. Sie gestattet zusammen mit einer dopplerunabhängigen Flussdarstellung eine bessere Einschätzung der Gefäßwandmorphologie, möglicher Ulzerationen, Dissektionen und Gefäßwandverletzungen. Künftig könnte eine 2D-Darstellung der Elastizität von Gefäßwand bzw. Plaque mit sehr hoher Bildrate zu einer breiteren klinischen Anwendung führen. Der möglicherweise größte Fortschritt dürfte in der gezielt eingesetzten kontrastverstärkten Sonographie liegen, da hiermit neben dem Gefäßlumen v. a. die Vasa vasorum und die Neovaskularisation von Plaques dargestellt werden können. Die Plaquevaskularisation wird als wichtiger Risikofaktor bei der Bewertung potenziell vulnerabler Plaques angesehen.
Abstract
The B-mode image quality of vessels has markedly increased with the advent of new transducer technologies. Morphological changes of the vessel wall, ulcerations, dissections or wall lesions benefit from non-Doppler dependent flow imaging methods. Two-dimensional imaging of the elasticity of the vessel wall may in future benefit from high speed imaging techniques. The biggest improvement in vessel imaging is probably the prudent use of contrast-enhanced ultrasound by which neovascularization can be visualized. Plaque vascularization is looked upon as an important risk factor in the evaluation of possible vulnerable plaques.
Literatur
O’Leary DH, Polak JF, Kronmal RA et al (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular health study collaborative research group. N Engl J Med 340(1):14–22
Baldassarre D, Tremoli E, Amato M et al (2000) Reproducibility validation study comparing analog and digital imaging technologies for the measurement of intima-media thickness. Stroke 31(5):1104–1110
Schmidt-Trucksäss A, Cheng DC, Sandrock M et al (2001) Computerized analysing system using the active contour in ultrasound measurement of carotid artery intima-media thickness. Clin Physiol 21(5):561–569
Seçil M, Altay C, Gülcü A et al (2005) Automated measurement of intima-media thickness of carotid arteries in ultrasonography by computer software. Diagn Interv Radiol 11(2):105–108
Cheng C, Tempel D, van Haperen R et al (2006) Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 113(23):2744–2753
Meairs S, Hennerici M (1999) Four-dimensional ultrasonographic characterization of plaque surface motion in patients with symptomatic and asymptomatic carotid artery stenosis. Stroke 30(9):1807–1813
Paini A (2007) Multiaxial mechanical characteristics of carotid plaque analysis by multiarray echotracking system. Stroke 38:117–123
Little WC, Constantinescu M, Applegate RJ et al (1998) Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 78(5 Pt 1):1157–1166
Wasserman BA, Wityk RJ, Trout HH 3rd, Virmani R (2005) Low-grade carotid stenosis: looking beyond the lumen with MRI. Stroke 36(11):2504–2513
Sabeti S, Schillinger M, Mlekusch W et al (2004) Quantification of internal carotid artery stenosis with duplex US: comparative analysis of different flow velocity criteria. Radiology 232(2):431–439
Weskott HP (2000) B-flow – a new method for detecting blood flow. Ultraschall Med 21(2):59–65
Jung EM, Kubale R, Clevert DA et al (2007) B-flow and B-flow with 3D and SRI postprocessing before intervention and monitoring after stenting of the internal carotid artery. Clin Hemorheol Microcirc 36(1):35–46
Clevert DA, Graser A, Jung EM et al (2008) Value of ultrasound in the diagnosis of aneurysms of the extracranial internal carotid arteries. Clin Hemorheol Microcirc 39(1–4):133–146
Grønholdt ML, Nordestgaard BG, Schroeder TV et al (2001) Ultrasonic echolucent carotid plaques predict future strokes. Circulation 104(1):68–73
Eliasziw M, Streifler JY, Fox AJ et al (1994) Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American symptomatic carotid endarterectomy trial. Stroke 25(2):304–308
Takaya N, Yuan C, Chu B et al (2006) Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events. A prospective assessment with MRI – initial results. Stroke 37:818–823
Zamir M, Silver MD (1985) Vasculature in the walls of human coronary arteries. Arch Pathol Lab Med 109:659–662
Barger AC, Beeuwkes R 3rd (1990) Rupture of coronary vasa vasorum as a trigger of acute myocardial infarction. Am J Cardiol 66:41G–43G
Naghavi M, Libby P, Falk E et al (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 108:1664–1672
Naghavi M, Libby P, Falk E et al (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part II. Circulation 108:1772–1778
Weskott HP (2008) Emerging roles for contrast-enhanced ultrasound. Clin Hemorheol Microcirc 40(1):51–71
Claudon M, Cosgrove D, Albrecht T et al (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) – update 2008. Ultraschall Med 29(1):28–44
Moreno PR, Purushothaman KR, Fuster V et al (2004) Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation 110(14):2032–2038
De Boer OJ, van der Wal AC, Teeling P et al (1999) Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization? Cardiovasc Res 41:443–449
Cao JJ et al (2003) C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly the cardiovascular health study. Circulation 108:166–170
Martin JF, Booth RF, Moncada S (1990) Arterial wall hypoxia following hyperfusion through the vasa vasorum is an initial lesion in atherosclerosis. Eur J Clin Invest 20:588–592
Kolodgie FD, Gold HK, Burke AP et al (2003) Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 349: 2316–2325
Lima JA, Desai MY, Steen H et al (2004) Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy. Circulation 110(16):2336–2341
Wilson SH, Herrmann J, Lerman LO et al (2002) Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering. Circulation 105(4):415–418
Li Xiong et al (2009) Correlation of carotid plaque neovascularization detected by using contrast-enhanced US with clinical symptoms. Radiology 251:583–589
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Weskott, H. Neue Trends in der Ultraschalldiagnostik der Karotisstenose. Radiologe 50, 591–596 (2010). https://doi.org/10.1007/s00117-009-1931-y
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DOI: https://doi.org/10.1007/s00117-009-1931-y
Schlüsselwörter
- Sonographische Gefäßdiagnostik
- Plaquemorphologie
- Vulnerabler Plaque
- Ultraschallkontrastmittel
- Plaquevaskularisation