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Klassifikation gastroenteropankreatischer neuroendokriner Tumoren

Classification of gastro-entero-pancreatic neuroendocrine tumors

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Zusammenfassung

Tumoren des disseminierten/diffusen neuroendokrinen Systems sind durch einen gemeinsamen Phänotyp gekennzeichnet. In ihrer Biologie unterscheiden sich neuroendokrine Tumoren (NET) jedoch bzgl. Morphologie, endokrinologischer Symptomatik und Ursprungsorgan. Die WHO-Klassifikation trägt diesen Unterschieden Rechnung und klassifiziert NET nach einem einheitlichen Vorgehen, wobei die Parameter Größe und Invasionstiefe je nach Ursprungsorgan variieren. Um die Nomenklatur weiter zu vereinheitlichen, wurde vor kurzem von der „European Neuroendocrine Tumor Society“ (ENETS) der Vorschlag einer TNM-Stadien-Einteilung und Graduierung gastroenteropankreatischer NET vorgelegt.

Abstract

Tumors of the disseminated/diffuse neuroendocrine system (NET) are characterized by a common phenotype. However, the biology varies according to histomorphology, endocrine symptoms and organ of origin. The WHO classification takes these differences into account and uses a common framework, where the parameters size and extent of invasion vary according to the organ of origin. In order to achieve a further standardization of reporting the European Neuroendocrine Tumor Society (ENETS) recently proposed a tumor-node-metastasis (TNM) staging and grading system for gastro-entero-pancreatic NET.

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Authors and Affiliations

  1. Institut für Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische UniversitätMünchen, Ismaningerstr. 22, 81675, München, Deutschland

    A. Perren

  2. Institut für klinische Pathologie, Departement Pathologie, Universitätsspital Zürich, Zürich, Schweiz

    A. Schmitt

  3. Institut für Pathologie, Stadtspital Triemli, Zürich, Zürich, Schweiz

    P. Komminoth

  4. Medizinische Klinik mit Schwerpunkt Hepatologie & Gastroenterologie, Charité, Universitätsmedizin Berlin, Berlin, Deutschland

    M. Pavel

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  1. A. Perren
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  2. A. Schmitt
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  3. P. Komminoth
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  4. M. Pavel
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Correspondence to A. Perren.

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Perren, A., Schmitt, A., Komminoth, P. et al. Klassifikation gastroenteropankreatischer neuroendokriner Tumoren. Radiologe 49, 198–205 (2009). https://doi.org/10.1007/s00117-008-1781-z

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  • DOI: https://doi.org/10.1007/s00117-008-1781-z

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