Skip to main content
Log in

Pitfalls in der kontrastverstärkten Lebersonographie: Konsequenzen für die Praxis

The nonspecific liver tumor: diagnoses please!

  • Ultraschall-Kontrastmittel
  • Published:
Der Radiologe Aims and scope Submit manuscript

Zusammenfassung

Die kontrastmittelverstärkte Sonographie im phaseninvertierten Kontrast- harmonischen Modus stellt eine vielversprechende neue Technik zur Detektion und Charakterisierung von Leberherden dar. So wird berichtet, dass sich maligne von benignen Lebertumoren mit einer fast 100%igen Sensitivität differenzieren ließen bzw. eine Artdiagnose mit einer Genauigkeit von über 90% möglich sei.

Über 7 Fälle aus dem eigenen Patientengut wird im Folgenden exemplarisch berichtet. Abschließend werden die so ermittelten Ergebnisse mit dem derzeitigen Wissensstand verglichen und diskutiert. Zusammenfassend können durch den zusätzlichen Einsatz der signalverstärkten Sonographie die meisten Leberläsionen korrekt charakterisiert werden; atypische Phänomene sollten dennoch bekannt sein, um die Befunde kritisch bewerten zu können.

Abstract

Contrast-enhanced sonography performed as phase inversion harmonic imaging is a promising new technique for detection and characterization of hepatic foci. It has been reported that malignant liver tumors can be differentiated from benign entities with almost 100% sensitivity and that diagnosis of the type is possible with an accuracy of over 90%.

The following report describes seven of our own cases and then compares the results we obtained with current knowledge, followed by a discussion. In summary, most hepatic lesions can be correctly characterized by supplemental use of enhanced sonography; practitioners should nevertheless be aware of atypical phenomena to be able to critically evaluate the findings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6
Abb. 7
Abb. 8
Abb. 9
Abb. 10
Abb. 11
Abb. 12
Abb. 13
Abb. 14
Abb. 15
Abb. 16
Abb. 17
Abb. 18
Abb. 19
Abb. 20
Abb. 21
Abb. 22
Abb. 23
Abb. 24

Literatur

  1. Albrecht T (2003) Contrast medium-supported sonography of the liver — a challenge to German radiology. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 175:889–891

    Article  CAS  PubMed  Google Scholar 

  2. Albrecht T, Blomley MJ, Heckemann RA, Cosgrove DO, Jayaram V, Butler-Barnes J, Eckersley RJ, Hoffmann CW, Bauer A (2000) Stimulated acoustic emissions with the ultrasound contrast medium levovist: a clinically useful contrast effect with liver-specific properties. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 172:61–67

    Article  CAS  PubMed  Google Scholar 

  3. Albrecht T, Hoffmann CW, Wolf KJ (2001) Ultrasound diagnosis of liver metastases with liver-specific contrast media. Radiologe 41:8–15

    Article  CAS  PubMed  Google Scholar 

  4. Beissert M, Jenett M, Keberle M, Kessler C, Klein D, Beer M, Hahn D (2000) Comparison of contrast harmonic imaging in B-mode with stimulated acoustic emission, conventional B-mode US and spiral CT in the detection of focal liver lesions. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 172:361–366

    Article  CAS  PubMed  Google Scholar 

  5. Borghi C, Aiani L, Sopransi M, Belloni G, Martegani A (2004) Current state of the use of sonographic contrast agents with low acoustic pressure techniques in the study of focal liver lesions. Radiol Med (Torino) 107:174–186; quiz 187–188

    Google Scholar 

  6. Brannigan M, Burns PN, Wilson SR (2004) Blood flow patterns in focal liver lesions at microbubble-enhanced US. Radiographics 24:921–935

    PubMed  Google Scholar 

  7. Bryant TH, Blomley MJ, Albrecht T, Sidhu PS, Leen EL, Basilico R, Pilcher JM, Bushby LH, Hoffmann CW, Harvey CJ, Lynch M, MacQuarrie J, Paul D, Cosgrove DO (2004) Improved characterization of liver lesions with liver-phase uptake of liver-specific microbubbles: prospective multicenter study. Radiology 232:799–809

    PubMed  Google Scholar 

  8. Dalla Palma L, Bertolotto M, Quaia E, Locatelli M (1999) Detection of liver metastases with pulse inversion harmonic imaging: preliminary results. Eur Radiol 9 [Suppl 3]:S382–387

  9. Hohmann J, Skrok J, Puls R, Albrecht T (2003) Characterization of focal liver lesions with contrast-enhanced low MI real time ultrasound and SonoVue. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 175:835–843

    Article  CAS  PubMed  Google Scholar 

  10. Isozaki T, Numata K, Kiba T, Hara K, Morimoto M, Sakaguchi T, Sekihara H, Kubota T, Shimada H, Morizane T, Tanaka K (2003) Differential diagnosis of hepatic tumors by using contrast enhancement patterns at US. Radiology 229:798–805

    PubMed  Google Scholar 

  11. Kim TK, Choi BI, Han JK, Hong HS, Park SH, Moon SG (2000) Hepatic tumors: contrast agent-enhancement patterns with pulse-inversion harmonic US. Radiology 216:411–417

    CAS  PubMed  Google Scholar 

  12. Lemke AJ, Chopra SS, Hengst SA, Brinkmann MJ, Steinmuller T, Felix R (2004) Characterization of hepatic tumors with contrast-enhanced ultrasound and digital grey-scale analysis. Rofo 176:1607–1616

    PubMed  Google Scholar 

  13. Quaia E, Bertolotto M, Calderan L, Mosconi E, Mucelli RP (2003) US characterization of focal hepatic lesions with intermittent high-acoustic-power mode and contrast material. Acad Radiol 10:739–750

    Article  PubMed  Google Scholar 

  14. Quaia E, Calliada F, Bertolotto M, Rossi S, Garioni L, Rosa L, Pozzi-Mucelli R (2004) Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: diagnostic performance and confidence. Radiology 232:420–430

    PubMed  Google Scholar 

  15. Quaia E, Degobbis F, Tona G, Mosconi E, Bertolotto M, Pozzi-Mucelli R (2004) Differential patterns of contrast enhancement in different focal liver lesions after injection of the microbubble US contrast agent SonoVue. Radiol Med (Torino) 107:155–165

    Google Scholar 

  16. Solbiati L, Tonolini M, Cova L, Goldberg SN (2001) The role ofcontrast-enhanced ultrasound in the detection of focal liver leasions. Eur Radiol 11 [Suppl 3]:E15–26

    Google Scholar 

  17. Strobel D, Hahn EG, Becker D (2001) Harmonic imaging for improving diagnosis of liver tumors — preliminary report. Z Gastroenterol 39:287–289, 292–294

    Article  CAS  PubMed  Google Scholar 

  18. Strobel D, Hoefer A, Martus P, Hahn EG, Becker D (2001) Dynamic contrast-enhanced power Doppler sonography improves the differential diagnosis of liver lesions. Int J Colorectal Dis 16:247–256

    Article  CAS  PubMed  Google Scholar 

  19. Strobel D, Raeker S, Martus P, Hahn EG, Becker D (2003) Phase inversion harmonic imaging versus contrast-enhanced power Doppler sonography for the characterization of focal liver lesions. Int J Colorectal Dis 18:63–72

    Article  PubMed  Google Scholar 

  20. Wilson SR, Burns PN, Muradali D, Wilson JA, Lai X (2000) Harmonic hepatic US with microbubble contrast agent: initial experience showing improved characterization of hemangioma, hepatocellular carcinoma, and metastasis. Radiology 215:153–161

    CAS  Google Scholar 

Download references

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to H. Strunk.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Strunk, H., Börner, N., Stuckmann, G. et al. Pitfalls in der kontrastverstärkten Lebersonographie: Konsequenzen für die Praxis. Radiologe 45, 529–543 (2005). https://doi.org/10.1007/s00117-005-1228-8

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00117-005-1228-8

Schlüsselwörter

Keywords

Navigation