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Vaskuläre Bildgebung mittels kontrastverstärkter Sonographie in der experimentellen Anwendung

Vascular imaging with contrast-enhanced sonography for experimental use

  • Ultraschallkontrastmittel
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Zusammenfassung

Die Möglichkeit des kontrastverstärkten Ultraschalls, Perfusion sensitiv zu detektieren, hat in medizinisch-biologischen, grundlagenorientierten Fragestellungen zu neuen Anwendungen geführt, die über die reine präklinische Evaluation dieser Techniken weit hinausgehen.

Es werden Methoden zur Visualisierung und Quantifizierung von Perfusion durch die kontrastverstärkte Sonographie erläutert und ein Überblick über bisherige Anwendungen dieser funktionellen Untersuchungen gegeben. Indikationen sind generell dann zu sehen, wenn Aussagen über die Gewebeperfusion mittels Ultraschall erforderlich sind, ein Thema, welches auch zunehmend klinisches Interesse gewinnt, z. B. in der Beurteilung der Myokard-, Hirn- oder Nierenperfusion oder im Therapiemonitoring. Dabei bieten unter den verschiedensten neuen Therapieverfahren, die am Tiermodell mittels Ultraschall im Verlauf untersucht wurden, insbesondere pro- oder antiangiogene Therapien vielversprechende Anwendungsgebiete für den kontrastverstärkten Ultraschall.

Abstract

The possibility of employing contrast-enhanced ultrasound for sensitive detection of perfusion has resulted in new forms of application in fundamental medical biological research that go far beyond mere preclinical evaluation of these techniques.

This contribution explains the methods for visualization and quantification of perfusion with contrast-enhanced sonography and provides an overview of how these functional examinations have been used to date. The procedure is generally considered indicated when information on tissue perfusion using ultrasound is required. This topic is also gaining increasing clinical interest, e.g., for assessment of myocardial, cerebral, and renal perfusion or for monitoring therapy. Among the various new treatment procedures that have been investigated in animal models with ultrasound, particularly proangiogenic and antiangiogenic therapy approaches proffer promising new fields for application of contrast-enhanced ultrasound.

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  1. Abteilung Radiologie, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg

    M. Krix, H.-U. Kauczor & S. Delorme

  2. Abteilung Radiologie, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg

    M. Krix

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  1. M. Krix
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Krix, M., Kauczor, HU. & Delorme, S. Vaskuläre Bildgebung mittels kontrastverstärkter Sonographie in der experimentellen Anwendung. Radiologe 45, 552–559 (2005). https://doi.org/10.1007/s00117-005-1186-1

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