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Magnetresonanztomographiegesteuerter fokussierter Ultraschall (MRgFUS) in der Tumortherapie—eine neuartige nichtinvasive Therapieoption

MR-guided focussed ultrasound surgery (MRgFUS)—a new noninvasive therapy modality

  • Thermotherapie
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Zusammenfassung

Insbesondere in der Tumortherapie wächst zunehmend die Nachfrage nach minimal- und nichtinvasiven Therapieverfahren. Als eine wertvolle und sichere, nichtinvasive Ergänzung der Thermoverfahren etabliert sich der hochfrequente fokussierte Ultraschall. Im vorliegenden Artikel werden die Vorteile einer MRT-Steuerung bei fokussiertem Ultraschall (MRgFUS) erläutert und erste klinische Erfahrungen in der Behandlung von Gebärmuttermyomen, Mammakarzinomen und Fibroadenomen mit MRgFUS vorgestellt. Auf der Basis der hohen Zielgenauigkeit der Methode und scharfen Demarkierung der erreichten Nekrosen bietet sich diese Behandlungsmethode für viele weitere Indikationen an. Zur Zeit werden Anstrengungen unternommen, MRgFUS auch für Anwendungen an Leber und Gehirn zu etablieren.

Abstract

The demand for minimal or non-invasive therapies especially in tumor therapy is increasing constantly. High frequency focussed ultrasound represents an effective and safe alternative to established thermoablative procedures. In this article we report the advantages of MR-guidance for focussed ultrasound. We describe first clinical experiences in the treatment of uterine fibroids, breast cancer and fibroadenomas of the breast employing MR-guided focussed ultrasound surgery (MRgFUS). This method offers strong potential in the treatment also of other tumorentities since it provides excellent accuracy. Currently numerous efforts are undertaken to introduce MRgFUS for the therapy of liver or cerebral tumors.

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Authors and Affiliations

  1. Klinik für Strahlenheilkunde, Campus-Virchow-Klinikum der Universitätsmedizin Berlin Charité

    S. A. Hengst, T. Ehrenstein, H. Herzog, A. Beck, R. Felix & J. Ricke

  2. Klinik für Frauenheilkunde und Geburtshilfe, Campus-Virchow-Klinikum der Universitätsmedizin Berlin Charité

    I. Utz-Billing & M. David

  3. Klinik für Strahlenheilkunde, Campus-Virchow-Klinikum der Universitätsmedizin Berlin Charité, Augustenburger Platz 1, 13353 , Berlin

    S. A. Hengst

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  1. S. A. Hengst
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  2. T. Ehrenstein
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Correspondence to S. A. Hengst.

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Hengst, S.A., Ehrenstein, T., Herzog, H. et al. Magnetresonanztomographiegesteuerter fokussierter Ultraschall (MRgFUS) in der Tumortherapie—eine neuartige nichtinvasive Therapieoption. Radiologe 44, 339–346 (2004). https://doi.org/10.1007/s00117-004-1043-7

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  • DOI: https://doi.org/10.1007/s00117-004-1043-7

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